한국식생활문화학회지 (Journal of the Korean Society of Food Culture)

  • 제33권3호
  • /
  • Pages.291-298
  • /
  • 2018
  • /
  • 1225-7060(pISSN)
  • /
  • 2288-7148(eISSN)
한국식생활문화학회 (Korean Society of Food Culture)
권호 표지
DOI QR코드

DOI QR Code

김천산 자두가 Streptozotocin 당뇨 유발 쥐에 미치는 영향

Effect of Plums Produced in Gimcheon on Metabolism in Streptozotocin-induced Diabetic Rats

  • 남지운 (경일대학교 식품산업융합학과) ;
  • 김광옥 (김천대학교 식품영양학과)
  • Nam, Ji-Woon (Department of Food Industry and Science, Kyungil University) ;
  • Kim, Kwang-Ok (Department of Food and Nutrition, Gimcheon University)
  • 투고 : 2018.06.21
  • 심사 : 2018.06.26
  • 발행 : 2018.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study examined the effects of plums produced in Gimcheon area on the glucose and lipid metabolism in streptozotocin-induced diabetic rats. Male Sprague-Dawley diabetic rats were divided into four groups: control, diabetic control, Diabetes-low plum (containing 10% plum powder), and Diabetes-high plum (containing 20% plum powder). The animals were fed isocaloric experimental diets based on an AIN-76 diet for 6 weeks. Feed efficiency ratio (FER) of the diabetic groups were significantly lower than that of the control. On the other hand, among the diabetic groups, the FER of the high plum intake group was higher than that of the diabetic control. The liver weight per 100 g body weight of each group was similar but the liver weights tended to decrease as the amount of plum intake was increased. Kidney weight per 100 g body weight of the plum intake groups were significantly different compared to that of the diabetic control. The supplementation of plums lowered the fasting blood glucose level of the diabetic groups and improved the glucose tolerance, thereby lowering the glycosylated hemoglobin index. In addition, the supplementation of plum was lowered the blood total cholesterol concentration and increased the HDL-C/TC (%) significantly, thereby lowering the atherosclerotic index (AI) and hepatic peroxide level. A steady diet of plums produced in Gimcheon may be effective in controlling the blood glucose level and preventing chronic diabetes mellitus.

키워드

참고문헌

  1. Addis PB, Warner GJ. 1991. The potential health aspects of lipid oxidation products in food. In: Auroma OI and Halliwell B Editors, Free radicals and food additives. Taylor and Francis, Ltd, London. pp. 77-119
  2. AOAC. 1990. Official methods of analysis. 15th ed. AOAC of Virginia, USA
  3. Baynes JW, Thorpe SR. 1999. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes., 48(1):1-9 https://doi.org/10.2337/diabetes.48.1.1
  4. Brooks DP, Nutting DF, Crofton JT, Share L. 1989 Vasopressin in rats with genetic and atreptozotocin-induced daiabetes. Diabetes., 38:54-57 https://doi.org/10.2337/diab.38.1.54
  5. Brownlee M, Vlassars H, Cerami A. 1984. Nonenzymematic glycosylation and the pathogenesis of diabetic complication. Ann Intern Med., 101:527-537 https://doi.org/10.7326/0003-4819-101-4-527
  6. Ceriello A, Ouatraro A, Giugliano D. 1992. New insights on. non-enzymatic glycosylation may lead to therapeutic approaches. for the prevention of diabetic complications. Diab Med., 9:297-299 https://doi.org/10.1111/j.1464-5491.1992.tb01783.x
  7. Donath MY. 2014. Targeting inflammation in the treatment of type 2 diabetes: Time to start. Nat Rev Drug Discov., 13(6):465-476 https://doi.org/10.1038/nrd4275
  8. Donovan JL, Meyer AS, Waterhouse AL. 1998. Phenolic composition and antioxidant activity of prunes and prune juice (Prunus domestica). J Agric Food Chem., 46:1247- 1252 https://doi.org/10.1021/jf970831x
  9. Eberhardt MV, Lee CY, Liu RH. 2000. Antioxidant activity of fresh apples. Nature., 405:903-904
  10. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. 2002. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev., 23(5):599-622 https://doi.org/10.1210/er.2001-0039
  11. Garcia MJ, McNamara PM, Gordon T, Kannell WB. 1974. Morbidity and mortality in diabetes in the Framingham population: Sixteen year follow-up study. Diabetes., 23: 105-111 https://doi.org/10.2337/diab.23.2.105
  12. Gimgheon agricultural technology center. Gimchen agriculture total data. http://gca.gc.go.kr/total/total19.asp
  13. Ham SS, Hong EH, Omura H. 1987. Desmutagenicity of enzymmatically browned substances obtained from reaction of Prumus salicina (red) enzyme and polyphenols. Food Sci Biotechnol., 19:212-219
  14. Han YH, Yon MY, Hyun TS. 2008. Effect of prune supplementation on dietary fiber intake and constipation relief. Korean J Community Nutrition., 13(3):426-438
  15. Jacob RA. 1995. The integrated antioxidant system. Nutr Res., 15(5):755-766 https://doi.org/10.1016/0271-5317(95)00041-G
  16. Jones H, Edwards L, Vallis TM, Ruggiero L, Rossi SR, Rossi J, Zinman B. 2003. Changes in diabetes self care behaviors make a difference in glycemic control: The Diabetes stages of change study. Diabetes Care., 26(3):732-737 https://doi.org/10.2337/diacare.26.3.732
  17. Jung GT, Ju IO, Chio DG, Ryu J, Ko BR, Choi JS, Choi YG. 2005. Chemical characteristics and physiological activities of plums (Oishiwase and Formosa) KOREAN J. FOOD SCI. TECHNOL., 37(5):816-821
  18. Kakkar R, Kalra J, Mantha SV, Prasad K. 1995. Lipid peroxidation and activity of antioxidant enzymes in diabetic rats. Molecular and Cellular Biochemistry., 151(1):13-119
  19. Kim DO, Jeong SW, Lee CY. 2003. Antioxidant capacity of phenolic phytochemicals from various cultivars of plums. Food Chem., 81:321-326 https://doi.org/10.1016/S0308-8146(02)00423-5
  20. Kim SN, Kim SY, Kim JB, Park HJ, Cho YS. 2013. Effect of Extracts from Oriental Plum (Formosa, Oishiwase, Soldam) on LPS-stimulated Raw 264.7 Cells. J East Asian Soc Dietary Life., 22(6):197-202
  21. Kim MY, Choi SW, Chung SK. 2000. Antioxidative flavonoids from the garlic (Allium sativum L.) shoot. Food Sci Biotechnol., 9:199-203
  22. Kim SH, Kang BT, Park DC, Yoon OH, Lee JW, Han MD, Choi JD. 2000. Physicochemical properties and chemical composition of plums produced in Kimcheon. J East Asian Soc Dietary Life., 10:37-41
  23. Kim YJ. 2000. Therapeutic strategies of soronary artery disease in diabetic patients. Korean Circulation J., 30(9):1184-1190 https://doi.org/10.4070/kcj.2000.30.9.1184
  24. Knekt P, Jarvinen R, Reunanen A, Maatela J. 1996. Flavonoid intake and coronary mortality in Finland: a cohort study. Br Med J., 312:478-481 https://doi.org/10.1136/bmj.312.7029.478
  25. Lee DH, Kwak DH, Kim SM, Ju EJ, Choi HG, Kim OH, Hwang JB, Bae NG, Jung KY, Han JC, Park HD, Chool YK. 2004. Effect of Small Black Soybean Powder on Blood Glucose and Insulin Sensitivity in Streptozotocin-Induced Diabetic Rats. J Korean Soc Food Sci Nutr., 33(10):1618-1625 https://doi.org/10.3746/jkfn.2004.33.10.1618
  26. Lee JS, Kim HJ, Yu MH, Im HG, Park DC. 2003. Antimicrobial activities of 'Formosa' plum at different growth stages against pathogenic bacteria. Korean J Food Preserv., 10: 569-573
  27. Lee SJ, Chung MJ, Shin JH, Sung NJ. 2000. Effect of natural foods on the inhibition of N-nitrosodimethylamine formation. J Fd Hyg Safety., 15:95-100.
  28. Monnier L, Mas E, Ginet C, Michel F, Villon L, Cristol JP, Colette C. 2006. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA., 295(14):1681-1687 https://doi.org/10.1001/jama.295.14.1681
  29. Nakazono K. 1991. Does superoxide underlie the pathogenesis of hypertension? Proc Natl Acad Sci., 88:10045-10048 https://doi.org/10.1073/pnas.88.22.10045
  30. Niall MG, Rosaleen AM, Daphne O, Patrick BC, Alan HJ, Gerald HT. 1990. Cholesterol metabolism in alloxan-induced diabetic rabbits. Diabetes., 39:626-636 https://doi.org/10.2337/diab.39.5.626
  31. Nourooz ZJ, Rahimi A, Tajaddini SJ, Tritschler H, Rosen P, Halliwell B, Betterige DJ. 1997. Relationships between plasma measures of oxidative stress and metabolic control NIDDM. Diabetologia., 40:647-653 https://doi.org/10.1007/s001250050729
  32. Ohara Y, Peterson TE, Harrison DG. 1993. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest., 91:2546-2551 https://doi.org/10.1172/JCI116491
  33. Reaven KM. 1987. Abnormal lipoprotein metabolism in non- insulin dependent diabetes mellitus. Am J Med., 83:31-40
  34. Statistics Korea. 2017. 2016 Agricultural production statistics. pp 103
  35. Statistics Korea. Prevalence of diabetes mellitus. http://kosis.kr.
  36. Stone BG, Van thiel Dh. 1985. Diabetes mellitus and the liver. Semin Liver Dis., 5:8-28 https://doi.org/10.1055/s-2008-1041754
  37. Survay NS, Ko EY, Upadhyay CP, Mi J, Park SW, Lee DH, Jung YS, Yoon DY, Hong SJ. 2010. Hypoglycemic Effects of Fruits and Vegetables in Hyperglycemic Rats for Prevention of Type-2 Diabetes. Kor. J. Hort. Sci. Technol., 28(5):850-856
  38. The Diabetes Control and Complications Trial Research Group. 1993. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med., 329(14):977-986 https://doi.org/10.1056/NEJM199309303291401
  39. UK Prospective Diabetes Study Group. 1998. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet. pp 854-865
  40. Wang H, Cao G, Prior RL. 1996. Total antioxidant capacity of fruits. J Agric Food Chem., 44:701-705 https://doi.org/10.1021/jf950579y
  41. West KM, Ahuja MMS, Bennett PH. 1983. The role of circulating glucose and triglyceride concentrations and their interaction with other 'risk factor' as determinations of alterial disease in nine diabetic population samples from the WHO multinational study. Diabetes Care., 6:361-369 https://doi.org/10.2337/diacare.6.4.361
  42. World Health Organization. 2003. World Health Organization, Adherence to long term therapies.
  43. Yoon OH, Kang BT, Lee JW, Kim KO. 2008. Effect of plum wine on the lipid metabolism and lipid peroxidation of rats. J Korean Soc Food Sci Nutr., 37(4):422-427 https://doi.org/10.3746/jkfn.2008.37.4.422
  44. Yu MH, Lee SO, Lm HG, Kim HJ, Lee IS. 2004. Antioxidant activities of Prunus salicina Lindl. cv. Soldam (Plum) at different growth stages. Korean J Food Preserv., 11:358-363