Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Antioxidative and Hair-growth-promotion Effects of a Fermented Compound Composed of Five Materials

발효 5종 혼합물의 항산화 및 모발 성장 촉진 효과

  • Lee, Ha Neul (Department of Pharmaceutical Engineering and College of Medical Life Science, Silla University) ;
  • Ha, Bae Jin (Department of Pharmaceutical Engineering and College of Medical Life Science, Silla University)
  • 이하늘 (신라대학교 바이오과학과 제약공학전공) ;
  • 하배진 (신라대학교 바이오과학과 제약공학전공)
  • Received : 2017.10.31
  • Accepted : 2018.06.18
  • Published : 2018.06.30
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Abstract

This study was performed to confirm the antioxidative and hair-growth-promotion effects of a fermented compound composed of five materials, namely Allium cepa, Cucurbita spp., Glycine max Merr., Pinus sylvestris leaf, and Sesamum indicum. An additional compound composed of two materials was composed of Allium cepa and Cucurbita spp. Antioxidative effects were measured based on DPPH radical-scavenging activity and total flavonoid content. Fermented 5-type natural compounds (5NC) showed higher DPPH radical-scavenging activity and flavonoid content than those of fermented 2-type natural compounds (2NC). Hair-growth promotion was demonstrated in vivo. Alkaline phosphatase (ALP), oid contentontenteptidase phospactivity, and macroscopic observation were measured. Experimental animals were divided into four groups based on the samples they were administered: water, pansildil (P-CON), 5NC, and 2NC. Samples were administered orally once a day at a fixed time for four weeks. Both ALP and ${\gamma}eeksactivity$ increased in the 5NC group compared with the 2NC group. In macroscopic observation, the P-CON group grew the most and were most similar to the state before shaving. The 5NC group grew hair similar to the P-CON group. In all the results, the 5NC group showed greater antioxidative and hair-growth-promotion effects than the 2NC group. Consequently, 5NC could be used as an ingredient for hair-growth promotion.

이 연구는 5가지 물질로 구성된 혼합물의 항산화 및 모발 성장 촉진 효과를 확인하기 위해 수행되었다. 발효 5종 혼합물은 적양파, 늙은 호박, 검은콩, 솔잎, 검은깨, 발효 2종 혼합물은 적양파, 늙은 호박으로 구성되어있다. 항산화 효과는 DPPH 라디칼 소거활성 및 총 플라보노이드 함량으로 측정하였다. 발효 5종 혼합물은 발효 2종 혼합물보다 높은 DPPH 라디칼 소거활성과 플라보노이드 함량을 보였다. 모발 성장 효과는 생체 내 실험을 통해 검증되었다. 알칼리성 인산가수 분해효소(ALP), ${\gamma}$-글루타밀트랜스펩티다아제(${\gamma}-GT$) 및 육안적 관찰을 통해 측정하였다. 실험동물은 샘플에 따라 물(NOR), 판시딜(P-CON), 발효 5종 혼합물(5NC), 발효 2종 혼합물(2NC) 총 4군으로 나눴다. 샘플은 일정한 시간에 하루 1번 4주 동안 경구투여하였다. 5NC군에서 ALP, ${\gamma}-GT$ 활성 모두 2NC에 비해 증가하였다. 육안적 관찰에서 P-CON군은 털이 가장 길고 면도 전의 상태와 유사하였다. 5NC군은 P-CON군과 유사한 수준으로 털이 자랐다. 모든 결과에서 발효 5종 혼합물은 발효 2종 혼합물 보다 높은 항산화 효과와 모발 성장 촉진 효과를 보였다. 결론적으로 발효 5종 혼합물은 유용한 모발 성장 촉진제의 원료로 사용할 수 있음을 확인하였다.

Keywords

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