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Study on the Novel Materials Containing Nanoparticles and Isocyanate Group for Strength Improvement of Hydrogel Ophthalmic Lens

  • Lee, Min-Jae (Department of Optometry & Vision Science, Catholic University of Daegu) ;
  • Sung, A-Young (Department of Optometry & Vision Science, Catholic University of Daegu)
  • Received : 2018.03.13
  • Accepted : 2018.06.25
  • Published : 2018.06.30

Abstract

This study was planned to prepare the high strength hydrogel ophthalmic lens containing isocyanate group and nanoparticles. HDI with carbon nanoparticles were used as additives for the basic combination of HEMA, MA and MMA, and the materials were copolymerized with EGDMA as the cross-linking agent and AIBN as the initiator. The mixture was heated at $100^{\circ}C$ for an hour to produce the high performance hydrogel ophthalmic lens by cast mold method. Measurement of the physical characteristics of the produced material showed that the refractive index was in the range of 1.4027~1.4600, water content 25.21~44.01%, contact angle $54.18{\sim}72.94^{\circ}$, visible light transmittance 53.03~92.09%, and tensile strength 0.1024~0.2359 kgf and breaking strength was 0.0872~0.2825 kgf. The results showed an increase of refractive index while the decrease in water content. And also, the breaking strength was highest when the addition ratio of HDI was 5%(wt). As a result of the absorbance measurement, no significant difference was observed in all the samples, so it can be judged that the stabilization of nanoparticles in the polymer was maintained.

Keywords

References

  1. T. Grosvenor, "Primary care optometry", Elsevier Health Science Division, Vol. 4, pp. 413-414, 2001.
  2. L. Jones, "Modern contact lens materials: a clinical performance update", Contact Lens Spectrum, Vol. 17, pp. 24-35, 2002.
  3. B. Tighe, "Soft lens materials", in Contact Lens Practice, ed. N. Efron, Oxford: Butterworth-Heine-mann, pp. 71-84, 2002.
  4. F. J. Holly and M. F. Refojo, "Wettability of hydrogels I. Poly(2 hydroxyethyl methacrylate)", J. Biomed. Mater. Res. A, Vol. 9, pp. 315, 1975. https://doi.org/10.1002/jbm.820090307
  5. K. L. Menzies and L. Jones, "The impact of contact angle on the biocompatibility of biomaterials", Optom. Vis. Sci., Vol. 87, pp. 387-399, 2010.
  6. K. L. Maki and D. S. Ross, "Exchange of tears under a contact lens is driven by distortions of the contact lens", Integr. Comp. Biol., Vol. 54, pp. 1043-1050, 2014. https://doi.org/10.1093/icb/icu092
  7. V. A. M. Luprano, P. A. Ramires, G. Montagna, and E. Milella, "Non-destructive characterization of hydrogels", J. Mater. Sci. Mater. Med., Vol. 8, pp. 175-178, 1997. https://doi.org/10.1023/A:1018527304576
  8. E. V. Aksenenko, V. I. Kovalchuk, V. B. Fainerman, and R. Miller, "Surface dilational rheology of mixed adsorption layers at liquid interfaces", Adv. Colloid Interface Sci., Vol. 122, pp. 57-66, 2006. https://doi.org/10.1016/j.cis.2006.06.012
  9. E. Dickinson, "Adsorbed protein layers at fluid interfaces: interactions, structure and surface rheology", Colloids Surf. B Biointerfaces, Vol. 15, pp. 161-176, 1999. https://doi.org/10.1016/S0927-7765(99)00042-9
  10. J. L. Bohnert, T. A. Horbett, B. D. Ratner, and F. H. Royce, "Adsorption of proteins from artificial tear solutions to contact lens materials", Invest. Ophthalmol. Vis. Sci., Vol. 29, pp. 362-373, 1988.
  11. M. R. Allansmith, D. R. Korb, J. V. Greiner, A. S. Henriquez, M. A. Simon, and V. M. Finnemore, "Giant papillary conjunctivitis in contact lens wearers", Am. J. Opthalmol., Vol. 83, pp. 697-708, 1977. https://doi.org/10.1016/0002-9394(77)90137-4
  12. E. Alfonso, S. Mandelbaum, M. Fox, and R. Forster, "Ulcerative keratitis associated with contact lens wear", Am. J. Opthalmol., Vol. 101, pp. 429-433, 1986. https://doi.org/10.1016/0002-9394(86)90641-0
  13. B. A. Holden, D. F. Sweeney, A. Vannas, K. T. Nilsson, and N. Efron, "Effects of long-term extended contact lens wear on the human cornea", Invest. Ophthalmol. Vis. Sci., Vol. 26, pp. 1489-1501, 1985.
  14. K. B. Masnick and B. A Holdent, "A study of water content and parametric variations of hydrophilic contact lenses", Aust. J. Optom., Vol. 55, pp. 481-487, 1972.
  15. T. H. Kim and A. Y. Sung, "Study on the functionality and application of natural-polymer with biocompatibility", Journal of the Korean Chemical Society, Vol. 53, pp. 547-552, 2009. https://doi.org/10.5012/jkcs.2009.53.5.547
  16. T. Sun, L. Feng, X. Gao, and L. Jiang, "Bioinspired surfaces with special wettability", Acc. Chem. Res., Vol. 38, pp. 644-652, 2005. https://doi.org/10.1021/ar040224c
  17. R. N. Wenzel, "Surface roughness and contact angle", J. Phys. Chem., Vol. 53, pp. 1466-1467, 1949. https://doi.org/10.1021/j150474a015
  18. E. A. Müller and K. E. Gubbins, "Molecular simulation study of hydrophilic and hydrophobic behavior of activated carbon surface", Carbon, Vol. 36, pp. 1433-1438, 1998. https://doi.org/10.1016/S0008-6223(98)00135-3
  19. U.S. Department of Health and Human Services, "Hazardous Substances Data Bank (HSDB, online database)", National Toxicology Information Program, National Library of Medicine, Bethesda, MD, 1993.