Industrial Production and Prospect of Breast Milk Oligosaccharide

모유올리고당의 산업적 생산 및 전망

  • Chin, Young-Wook (Traditional Food Research Group, Korea Food Research Institute)
  • 진영욱 (한국식품연구원 전통식품연구단)
  • Published : 2018.05.23

Abstract

Keywords

References

  1. Baumgartner F, Seitz L, Sprenger GA, Albermann C. 2013. Construction of Escherichia coli strains with chromosomally integrated expression cassettes for the synthesis of 2'-fucosyllactose. Microbial Cell Factories 12(1): 40. https://doi.org/10.1186/1475-2859-12-40
  2. Bode L. 2012. Human milk oligosaccharides: Every baby needs a sugar mama. Glycobiology 22(9): 1147-1162. https://doi.org/10.1093/glycob/cws074
  3. Bode L. 2015. The functional biology of human milk oligosaccharides. Early Human Development 91(11): 619-622. https://doi.org/10.1016/j.earlhumdev.2015.09.001
  4. Chin YW, Seo NR, Kim JH, Seo JH. 2016. Metabolic engineering of Escherichia coli to produce 2'-fucosyllactose via salvage pathway of guanosine 5'-diphosphate (GDP)-L-fucose. Biotechnology and Bioengineering.
  5. Chin YW, Kim JY, Kim JH, Jung SM, Seo JH. 2017. Improved production of 2′-fucosyllactose in engineered Escherichia coli by expressing putative ${\alpha}$-1,2-fucosyltransferase, WcfB from Bacteroides fragilis. Journal of Biotechnology 257: 192-198. https://doi.org/10.1016/j.jbiotec.2016.11.033
  6. Crane J, Crane JK, Azar SS, Stam A, Newburg DS. 1994. Oligosaccharides from human milk block binding and activity of the Escherichia coli heat-stable enterotoxin (STa) in T84 intestinal cells. Journal of Nutrition 124(12): 2358. https://doi.org/10.1093/jn/124.12.2358
  7. Donovan SM. 2017. Human milk oligosaccharides: Potent weapons in the battle against Rotavirus infection. The Journal of Nutrition 147(9): 1605-1606. https://doi.org/10.3945/jn.117.255836
  8. Drouillard S, Driguez H, Samain E. 2006. Large-scale synthesis of H-antigen oligosaccharides by expressing Helicobacter pylori ${\alpha}$-1,2-fucosyltransferase in metabolically engineered Escherichia coli cells. Angewandte Chemie 118(11): 1810-1812. https://doi.org/10.1002/ange.200503427
  9. Eiwegger T, Stahl B, Schmitt J, Boehm G, Gerstmayr M, Pichler J, Dehlink E, Loibichler C, Urbanek R, Szepfalusi Z. 2004. Human milk-derived oligosaccharides and plant-derived oligosaccharides stimulate cytokine production of cord blood T-cells in vitro. Pediatric Research 56(4): 536. https://doi.org/10.1203/01.PDR.0000139411.35619.B4
  10. Eiwegger T, Stahl B, Haidl P, Schmitt J, Boehm G, Dehlink E, Urbanek R, Szepfalusi Z. 2010. Prebiotic oligosaccharides: In vitro evidence for gastrointestinal epithelial transfer and immunomodulatory properties. Pediatric Allergy and Immunology 21(8): 1179-1188. https://doi.org/10.1111/j.1399-3038.2010.01062.x
  11. Endo T, Koizumi S, Tabata K, Ozaki A. 2000. Large-scale production of CMP-NeuAc and sialylated oligosaccharides through bacterial coupling. Applied Microbiology and Biotechnology 53(3): 257-261. https://doi.org/10.1007/s002530050017
  12. Fierfort N, Samain E. 2008. Genetic engineering of Escherichia coli for the economical production of sialylated oligosaccharides. Journal of Biotechnology 134(3-4): 261-265. https://doi.org/10.1016/j.jbiotec.2008.02.010
  13. Han NS, Kim TJ, Park YC, Kim JH, Seo JH. 2012. Biotechnological production of human milk oligosaccharides. Biotechnology Advances 30(6): 1268-1278. https://doi.org/10.1016/j.biotechadv.2011.11.003
  14. Jantscher-Krenn E, Lauwaet T, Bliss LA, Reed SL, Gillin FD, Bode L. 2012. Human milk oligosaccharides reduce Entamoeba histolytica attachment and cytotoxicity in vitro. British Journal of Nutrition 108(10): 1839-1846. https://doi.org/10.1017/S0007114511007392
  15. Koizumi S, Endo T, Tabata K, Nagano H, Ohnishi J, Ozaki A. 2000. Large-scale production of GDP-fucose and Lewis X by bacterial coupling. Journal of Industrial Microbiology and Biotechnology 25(4): 213-217. https://doi.org/10.1038/sj.jim.7000055
  16. Lucas A, Morley R, Cole TJ, Lister G, Leeson-Payne C. 1992. Breast milk and subsequent intelligence quotient in children born preterm. Lancet 339:261-264. https://doi.org/10.1016/0140-6736(92)91329-7
  17. Mattila P, Rabina J, Hortling S, Helin J, Renkonen R. 2000. Functional expression of Escherichia coli enzymes synthesizing GDP-L-fucose from inherent GDP-D-mannose in Saccharomyces cerevisiae. Glycobiology 10, 1041. https://doi.org/10.1093/glycob/10.10.1041
  18. Newburg DS, Walker WA. 2007. Protection of the neonate by the innate immune system of developing gut and of human milk. Pediatric Research 61(1): 2. https://doi.org/10.1203/01.pdr.0000250274.68571.18
  19. Petschacher B, Nidetzky B. 2016. Biotechnological production of fucosylated human milk oligosaccharides: Prokaryotic fucosyltransferases and their use in biocatalytic cascades or whole cell conversion systems. Journal of Biotechnology 235: 61-83. https://doi.org/10.1016/j.jbiotec.2016.03.052
  20. Prieto PA, Mukerji P, Kelder B, Erney R, Gonzalez D, Yun JS, Smith DF, Moremen KW, Nardelli C, Pierce M. 1995. Remodeling of mouse milk glycoconjugates by transgenic expression of a human glycosyltransferase. Journal of Biological Chemistry 270, 29515-29519. https://doi.org/10.1074/jbc.270.49.29515
  21. Prieto PA. 2012. Profiles of human milk oligosaccharides and production of some human milk oligosaccharides in transgenic animals. Advances in Nutrition 3, 456S-464S. https://doi.org/10.3945/an.111.001529
  22. Sela D, Mills D. 2010. Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides. Trends in Microbiology.
  23. Smilowitz JT, O'Sullivan A, Barile D, German JB, Lonnerdal B, Slupsky CM. 2013. The human milk metabolome reveals diverse oligosaccharide profiles. The Journal of Nutrition 143(11): 1709-1718. https://doi.org/10.3945/jn.113.178772
  24. https://www.futuremarketinsights.com/reports/human-milk-oligosaccharides-market.
  25. https://ourworldindata.org/world-population-growth.