대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제39권3호
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  • Pages.140-145
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  • 2018
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  • 1229-0807(pISSN)
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  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
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전하가 다른 PLGA 나노 입자의 생체 안정성 및 암세포에 미치는 영향

The Biostability and Cancer Effect of PLGA Nanoparticles with Different Charges

  • 김인우 (연세대학교 보건과학대학 의공학부) ;
  • 박승빈 (연세대학교 보건과학대학 의공학부) ;
  • 지유현 (연세대학교 보건과학대학 의공학부) ;
  • 박상효 (연세대학교 보건과학대학 의공학부) ;
  • 기재홍 (연세대학교 보건과학대학 의공학부)
  • Kim, Inwoo (Department of Biomedical Engineering, College of Health Sciences, Yonsei University) ;
  • Park, Seungbin (Department of Biomedical Engineering, College of Health Sciences, Yonsei University) ;
  • Ji, Yuhyun (Department of Biomedical Engineering, College of Health Sciences, Yonsei University) ;
  • Park, Sanghyo (Department of Biomedical Engineering, College of Health Sciences, Yonsei University) ;
  • Key, Jaehong (Department of Biomedical Engineering, College of Health Sciences, Yonsei University)
  • 투고 : 2018.01.12
  • 심사 : 2018.05.28
  • 발행 : 2018.06.30
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초록

Cancer is a major burden of human disease worldwide. Current chemotherapy has severe side effects because the drugs affect whole body nonspecifically. In addition, the drugs to reach cancer cells are very limited. Over the last two decades, Drug Delivery System (DDS) using nanoparticles has suggested promising results to improve current limitations. In this study, we prepared PLGA nanoparticles with different charge properties and observed their stability and internalization effect to cancer cells. Results using Dynamic Light Scattering (DLS) and Fourier Transform Infrared Spectroscopy (FTIR) confirmed the size and chemical composition of the nanoparticles. The stability of the nanoparticles in pH buffers were variable depending on charge properties. The nanoparticles showed different cytotoxicity and internalization effects to MCF-7 human breast cancer cells. In conclusion, we demonstrated the importance of delicately engineered nanoparticles for better DDS in cancer.

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