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신바이오틱스의 생리활성에 관한 연구 고찰

Studies on the Biological Activity of Synbiotics: A Review

  • 투고 : 2018.01.30
  • 심사 : 2018.05.18
  • 발행 : 2018.06.30

초록

This paper defines the common features of synbiotics based on the definition of probiotics and prebiotics, and reviews the effectiveness of synbiotic food. The concept of synbiotics is defined as 'a mixture of prebiotics and probiotics that have a beneficial effect on the host, as a dietary supplement that alters living organisms in the gastrointestinal tract and improves their survival.' Synbiotic food contains ingredients with beneficial microbes that are expected to improve interactions between microbial and useful substances. Synbiotic foods may have anti-cancer and immune system-boosting effects. Improved digestion, healthier bowel movements, and overall increased intestinal health has been reported were reported after increasing the healthy microorganisms within the intestinal tract. In addition, depending on the type of food containing the symbiotic ingredients, more consistent weight control, improvement of cardiovascular health, and lower blood glucose levels may also be expected. Unlike previous studies, this review of synbiotics has shown that it is necessary for synergistic effects to take place among microorganisms and components to be further studied. Further research is needed on the safety and ingestion of microorganisms contained in synbiotics.

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참고문헌

  1. Alm L, Ryd-Kjellen E, Setterberg G, Blimquist L. 1993. Effect of new fermented milk product, cultura, on constipation in geriatric patients. 1st Lactic Acid Bacteria Norfolk Computer Conf Norfolk
  2. An SJ, Kim JY, Choi IS, Cho KK. 2013. Insight into the roles of prebiotics and probiotics in the large intestine. J Life Sci 23:1295-1303 https://doi.org/10.5352/JLS.2013.23.10.1295
  3. Asahara T, Kensuke S, Nomoto K, Hamabata T, Ozawa A, Takeda Y. 2004. Probiotic bifidobactera protect mice from lethal infection with shiga toxin-producing Escherichia coli O157:H7. Infect Immun 72:2240-2247 https://doi.org/10.1128/IAI.72.4.2240-2247.2004
  4. Beddows CG. 1997. Fermented Fish and Fish Products, in Microbiology of Fermented Food. pp.416-440. Springers
  5. Bengmark S. 2001. Use of prebiotics, probiotics and synbiotics in clinical immunonutrition. Proc Intl Sym Food Nutr Health for 21st Century Seoul pp.187-213
  6. Bettler J, Miychel DK, Kullen MJ. 2006. Administration of Bifidobacterium lactis with fructo-oligosaccharide to toddlers is safe and results in transient colonization. Int J Probiotics Prebiotics 1:193-202
  7. Buriti FCA, Cardarelli HR, Filisetti TMCC, Saad SMI. 2007. Synbiotic potential of fresh cream cheese supplemented with inulin and Lactobacillus paracasei in co-culture with Streptococcus thermophilus. Food Chem 104:1605-1610 https://doi.org/10.1016/j.foodchem.2007.03.001
  8. Cardarelli HR, Buriti FCA, Castro IA, Saad SMI. 2008. Inulin and oligofructose improve sensory quality and increase the probiotc viable count in potentaially synbiotic petit-suisse cheese. LWT-Food Sci Technol 41:1037-1046 https://doi.org/10.1016/j.lwt.2007.07.001
  9. Chandan RC, Shah NP. 2007. Functional foods based on dairy ingredients. In Handbook of Food Products Manufacturing-Principles, Bakery, Beverage, Cereals, Cheese, Confectionary, Fats, Fruits, and Functional Foods. pp.971-987. John Wiley & Sons
  10. Chang JH, Shim YY, Cha SK, Chee KM. 2010. Probiotic characteristics of lactic acid bacteria isolated from kimchi. J Appl Microbiol 109:220-230
  11. Chang JY, Chang HC. 2010. Improvements in the quality and shelf life of kimchi by fermentation with the induced bacteriocin-producing strains, Leuconostoc citreum GJ7 as a starter. J Food Sci 75:M103-M110 https://doi.org/10.1111/j.1750-3841.2009.01486.x
  12. Chen C, Rui X, Lu Z, Li W, Dong M. 2014. Enhanced shelf-life of tofu by using bacteriocinogenic Weissella hellenica D1501 as bioprotective cultures. Food Control 46:203-209 https://doi.org/10.1016/j.foodcont.2014.05.004
  13. Cho SY, Joo DS, Park Sh, Kang HJ, Jeon JK. 2000. Changes of taurine content in squid meat during squid processing and taurine content in the squid processing waste water. Korean J Fish Aquat Sci 33:51-54
  14. Choi JM, Lee SH, Park KY, Kang SA, Cho EJ. 2014. Protective effect of kimchi against $A{\beta}_{25-35}$-induced impairment of cognition and memory. J Korean Soc Food Sci Nutr 43:360-366 https://doi.org/10.3746/jkfn.2014.43.3.360
  15. Chouraqui JM, Grathwall D, Labaune JM, Hascoet JM, Montgolfer I, de Leclaire M, Giarre M, Steenhout P. 2008. Assessment of the safety, tolerance, and protective effect against diarrhoea of infant formulas containing mixtures of probiotics or probiotics and prebiotics in a randoized controlled trial. Am J Clin Nutr 87:1365-1373 https://doi.org/10.1093/ajcn/87.5.1365
  16. Commane DM, Shortt CT, Silvi S, Cresci A, Hughes RM, Rowland IR. 2010. Effects of fermentation products of pro-and prebiotics on trans-epithelial electrical resistance in an in vitro model of the colon. Nutr Cancer 51:102-109
  17. Crittenden RG. 1999. Prebiotics, in Probiotics: A Critical Review. pp.141-156. Horizon Scientific Press
  18. Cui M, Kim HY, Lee KH, Jeong JK, Hwang JH, Yeo KY, Ryu BH, Choi JH, Park KY. 2015. Antiobesity effects of kimchi in diet-induced obese mice. J Ethnic Foods 2:137-144 https://doi.org/10.1016/j.jef.2015.08.001
  19. de Cruz AG, Walter EHM, Cadena RS, Faria JAF, Bolini HMA, Franttini Fileti AM. 2009. Monitoring the authenticity of low-fat yogurts by an artificial neural network. J Dairy Sci 92:4797-4804 https://doi.org/10.3168/jds.2009-2227
  20. Dekker K. 2008. The science behind the success of probiotics and prebiotics. Food Products Design 18:76-85
  21. Duarte J, Vinderola G, Ritz B, Perdigon G, Matar C. 2006. Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation. Immunol 211:341-350
  22. Fisberg M, Maulen-Radovan IE, Torno R, Crasscoco MT, Giner CP, Martin FA, Belinchon P, Cosat CM, Perez MP, Caro JG, Garibay EMV, Aranda JAG, Po IMA, Silva Guerra AJM, Martinez SV, McCue M, Alarcon P, Corner GM. 2002. Effect of oral nutrition supplementation with or without synbiotics on sickness and catch-up growth in preschool children. Int Pediatr 17:216-222
  23. Food and Agriculture Organization. 2006. Probiotics in Food: Health and Nutritional Properties and Guidelines for Evaluation. p.85
  24. Forchielli ML, Walker WA. 2005. The role of gut associated lymphoid tissue and mucosal defence. Brit J Nutr 93: S41-S48 https://doi.org/10.1079/BJN20041356
  25. Ford AC, Quigley EM, Lacy BE, Lembo AJ, Saito YA, Schiller LR, Soffer EE, Spiegel BM, Moayyedi P. 2014. Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: Systematic review and meta-analysis. Am J Gastroenterol 109:1547-1561 https://doi.org/10.1038/ajg.2014.202
  26. Furrie E, Macfarlane S, Kennedy A, Cummings JH, Walsh SV, O'Neil DA, Macfarlane GT. 2005. Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: A randomised controlled pilot trial. Gut 54:242-249 https://doi.org/10.1136/gut.2004.044834
  27. Gibson GR, Roberfroid MB. 1995. Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics. J Nutr 125:1401-1412
  28. Gill HS, Cross M. 2002. Probiotics and immune function. In Nutrition and Immune Function. pp.251-272. CABI Publishng
  29. Gomes A, Rodriguez D, Freitas AC, Rocha Santos T, Goodfel- low B. 2009. Synbiotic cheese: Effect of prebiotic compounds on survival of probiotic strains throughout ripening time. New Biotechnol 25:S94
  30. Guarner F. 2008. Prebiotics in inflammatory bowel disease, in Handbook of Prebiotics. pp.375-392. CRC Press
  31. Hatakka K, Ahola AJ, Yli-Knuuttila H, Richardson M, Poussa T, Meurman JH, Korpela R. 2007. Probiotics reduce the prevalence of oral Candida in the delderly. A randomized controlled trial. J Dent Res 86:125-130 https://doi.org/10.1177/154405910708600204
  32. Hekmat S, Reid G. 2006. Sensory properties of probiotic yogurt is comparable to standard yogurt. Nutr Res 26:163-166 https://doi.org/10.1016/j.nutres.2006.04.004
  33. Hutkins RW, Krumbeck JA, Bindels LB, Cani PD, Fahey Jr G, Goh YJ, Hamaker B, Martens EC, Mills DA, Rastal RA, Vaughan E, Sanders ME. 2016. Prebiotics: Why definition matter. Curr Opin Biotechnol 37:1-7 https://doi.org/10.1016/j.copbio.2015.09.001
  34. Isolauri E, Arvola T, Sutas Y, Moilanen E, Salminen S. 2000. Probiotics in the management of atopic eczema. Clin Exp Allergy 30:1604-1610
  35. Itou K, Nagahashi R, Saitou M, Akahane Y. 2007. Antihypertensive effect of narezushi, a fermented mackerel product, on spontaneously hypertensive rats. Fish Sci 73:1344-1352
  36. Kanamori Y, Sugiyama M, Komura M, Nakahara S, Sato K, Iwanka T, Yuki N, Morotomi M, Takahashi T, Tanaka R. 2006. Synbiotic therapy: An important supportive therapy for pediatric patients with severe respiratory diseases. Intl J Probioti Prebiot 1:161-168
  37. Karimi R, Azziz MH, Ghasemlou M, Vaziri M. 2015. Application of inulin in cheese as prebiotic, fat replacer and texturizer: A review. Carbohydrate Polymers 119:85-100 https://doi.org/10.1016/j.carbpol.2014.11.029
  38. Kim BK. 2009. Antiaging effects and anticancer mechanisms of kimchi during fermentation. Ph.D. Thesis, Pusan Natl Univ. Korea
  39. Kim DC, Chae HJ, In MJ. 2004. Existence of stable fibrin-clotting inhibitor in salt-fermented anchovy sauce. J Food Compos Anal 17:113-118 https://doi.org/10.1016/S0889-1575(03)00106-6
  40. Kim EK, An SY, Lee MS, Kim TH, Lee HK, Hwang WS, Choe SJ, Kim TY, Han SJ, Kim HJ, Kim DJ, Lee KW, 2011. Fermented kimchi reduces body weight and improves metabolic parameters in overweight and obese patients. Nutr Res 31:436-443 https://doi.org/10.1016/j.nutres.2011.05.011
  41. Kim JH, Ryu JD, Lee HG, Park JH, Moon GS, Cheigh HS, Song YO. 2002. The effect of kimchi on production of free radicals and antioxdative enzyme acitivities in the brain of SAM. J Korean Soc Food Sci Nutr 31:117-123 https://doi.org/10.3746/jkfn.2002.31.1.117
  42. Kim SY, Shin S, Koo HC, Youn JH, Paik HD, Park YH. 2010. In vitro antimicrobial effect and in vivo preventive and therapeutic effects of partially purified lantibiotic lacticin NK34 against infection by Staphylococcus species isolated from bovine mastitis. J Dairy Sci 93:3610-3615 https://doi.org/10.3168/jds.2010-3129
  43. Kim YH. 2016. Probiotics, prebiotics, synbiotics and human health. BT News 23:17-22
  44. Klaenhammer TR. 2007. Probiotics and prebiotics. In Food Microbiology-Fundamental and Frontiers. 3rd ed. pp.891-910. ASM Press
  45. Kleekayai T, Saetae D, Wattanachaiyingyong O, Tachibana S, Yasuda M, Suntornsuk W. 2015. Characterization and in vitro biological activities of Thai traditional fermented shrimp pastes. J Food Sci Technol 52:1839-1848 https://doi.org/10.1007/s13197-014-1528-y
  46. Lee DY, Kim SJ, Cho JH, Kim JH. 2008a. Microbial population dynamics and temperature changes during fermentation of kimjang kimchi. J Microbiol 46:590-593 https://doi.org/10.1007/s12275-008-0156-5
  47. Lee MK, Lee JK, Son JA, Kang MH, Koo KH, Suh JW. 2008b. S-adenosyl-L-methionine (SAM) production by lactic acid bacteria strains isolated from different fermented kimchi product. Food Sci Biotechnol 17:857-860
  48. Lee SY, Song YO, Han ES, Han JS. 2012. Comparative study on dietary habits, food intakes, and serum lipid levels according to kimchi consumption in college students. J Korean Soc Food Sci Nutr 41:351-361 https://doi.org/10.3746/jkfn.2012.41.3.351
  49. Lee YG, Lee KW, Kim JY, Kim KH, Lee HJ. 2004. Induction of apoptosis in a human lymphoma cell line by hydrophobic peptide fraction separated from anchovy sauce. BioFactors 21:63-67 https://doi.org/10.1002/biof.552210112
  50. Lilly DM, Stillwell RH. 1965. Probiotics: Growth-promoting factors produced by microorganisms. Science 147:747-748 https://doi.org/10.1126/science.147.3659.747
  51. Lim ES, Kim YM, Lee EW. 2016. Probiotic properties and safety assessment of lactic acid bacteria isolated from salt-fermented anchovy. Korean J Food Sci Techol 48:306-316 https://doi.org/10.9721/KJFST.2016.48.4.306
  52. Lopetcharat K, Choi YJ, Park JW, Daeschel MA. 2001. Fish sauce products and manufacturing: A review. Food Rev Int 17:65-88 https://doi.org/10.1081/FRI-100000515
  53. Martinez-Alvarez O, Lopez-Caballero ME, Gomez-Guillen MC, Montero P. 2016. Fermented seafood products and health. In Fermented Foods in Health and Disease Prevention. pp.177-202. Acadmic Press
  54. Moon YJ, Soh JR, Yu JJ, Sohn HS, Cha YS, Oh SH. 2012. Intracellular lipid accumulation inhibitory effect of Weissella koreensis OK1-6 isolated from kimchi on differentiating adipocyte. J Appl Microbiol 113:652-658 https://doi.org/10.1111/j.1365-2672.2012.05348.x
  55. Murofushi M, Shiomi M, Aibara K. 1983. Effect of orally administered polysaccharide from kefir grain on delayed-type hypersensitivity and tumor growth in mice. Jpn J Med Sci Biol 36:49-53 https://doi.org/10.7883/yoken1952.36.49
  56. Nadal ES. 2008. Application of prebiotics and probiotics in meat products. In Technological Strategies for Functional Meat Products Development. pp.117-137. Transworld Research Network
  57. O'Bryan CA, Pak D, Crandall PG, Lee SO, Ricke SC. 2013. The role of prebiotics and probiotics in human health. J Probiotics Health 1:108
  58. Oh SR, Zhang CY, Kim TL, Hong SJ, Ju IS, Lee SH, Kim SH, Cho JI, Ha SD. 2014. Iactivation of Anisakis larvae in salt-fermented squid and pollock tripe by freezing, salting, and combined treatment with chlorine and ultrasound. Food Contl 40:46-49 https://doi.org/10.1016/j.foodcont.2013.11.023
  59. Oliveira RPS, Casazza AA, Aliakbarian B, Perego P, Converti A, Oliveira MN. 2013. Influence of fructooligosaccharides on the fermentation profile and viable counts in a symbiotic low fat milk. Braz J Microbiol 44:431-434 https://doi.org/10.1590/S1517-83822013000200014
  60. O'May GA, Reynolds N, Macfarlane GT. 2005. Effect of pH on an in vitro model of gastric microbiota in enteral nutrition patients. Appl Environ Microbiol 71:4777-4783 https://doi.org/10.1128/AEM.71.8.4777-4783.2005
  61. Ouwehand AC, Kirjavainen PV, Shortt C, Salminen S. 1999. Probiotics: Mechanisms and established effects. Intl Dairy J 9:43-52 https://doi.org/10.1016/S0958-6946(99)00043-6
  62. Pandey KR, Naik SR, Vakil BV. 2015. Probiotics, prebiotics and synbiotics-a review. J Food Sci Technol 52:7577-7587 https://doi.org/10.1007/s13197-015-1921-1
  63. Park KY, Ha JO, Rhee SH. 1996. A study on the contents of dietary fibers and crude fiber in kimchi ingredients and kimchi. J Korean Soc Food Nutr 25:69-75
  64. Park KY, Kim HY, Jeong JK. 2016. Kimchi and its health benefits. In Fermented Food in Health and Disease Prevention. pp.477-502. Academic Press
  65. Park KY, Rhee SH. 2005. Functional foods from fermented vedetable products: Kimchi (Korean fermented vegetables) and functionality. In Asian Functional Foods. pp.341-380. CRC Press
  66. Petuely F. 1958. Der Bifidofaktor. Deutsch Med Wochenschr 82:1957-1960
  67. Plessas S, Bosnea L, Alexopouos A, Bezirtzoglou E. 2012. Potential effects of probiotics in cheese and yogurt production: A review. Eng Lif Sci 12:433-440 https://doi.org/10.1002/elsc.201100122
  68. Pyo YH, Oh HJ. 2011. Ubiquinone contents in Korean feremented foods and average daily intakes. J Food Compos Anal 24:1123-1129 https://doi.org/10.1016/j.jfca.2011.03.018
  69. Rodrigues D, Rocha-Santosa TAP, Gomes AM, Goodfellow BJ, Freitasa AC. 2015. Lipolysis in probiotic and synbiotic cheese: The influence of probiotic bacteria, prebiotic compounds and ripening time on free fatty acid profiles. Food Chemistry 131:1414-1421
  70. Roller M, Clune Y, Collins K, Rechkemmer G, Watzl B. 2007. Consumption of prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacilllus rhamnosus and Bifidobacterium lactis has minor effects on selected immune parameters in polypectomised and colon cancer. Br J Nutr 97:676-684 https://doi.org/10.1017/S0007114507450292
  71. Segawa S, Hayashi A, Nakakita Y, Kaneda H, Watari J, Yasui H. 2008. Oral administration of heat-killed Lactobacillus brevis SBC8803 ameliorate the development of dermatitis and inhibits immunoglobulin E production in atopic dermatitis model NC/Nga mice. Biol Pharm Bull 31:884-889 https://doi.org/10.1248/bpb.31.884
  72. Shah NP, da Cruz AGD, Faria JAF. 2010. Probiotics and Prebiotic Foods: Technology, Stability and Benefits to Human health. Nova Science Publishers, Inc
  73. Shin KS, Chae OW, Park IC, Hong SK, Choe TB. 1998. Antitumor effects of mice fed with cell lysate of Lactobacillus plantarum isolated from kimchi. Korean J Biotechol Bioeng 13:357-363
  74. Silva AM, Barbosa FHF, Duarte R, Vieira LQ, Arantes RME, Niocli JR. 2003. Effect of Bifidobacterium longum ingestion on experimental salmonellosis in mice. J Appl Microbiol 97:29-37
  75. Terada A, Hara H, Katapka M, Mitsuoka T. 1992. Effect of lactulose on the composition and metabolic activity of the human faecal flora. Micobial Ecol Health Dis 5:43-50 https://doi.org/10.3109/08910609209141303
  76. Thapa N, Pal J, Tamang JP. 2004. Microbial diversity in ngari, hentak, and tungkap, fermented fish products of North-East India. World J Microbiol Biotechnol 20:599-607 https://doi.org/10.1023/B:WIBI.0000043171.91027.7e
  77. Tuohy KM, Probert HM, Smejkal CW, Gibson GR. 2003. Using probiotics and prebiotics to improve gut health. Drug Discovery Today 8:692-700 https://doi.org/10.1016/S1359-6446(03)02746-6
  78. Van Loo J, Clune Y, Bennett M, Collins JK. 2005. The SYNCAN project: Goals, set-up, first results and settings of the human inervention study. Br J Nutr 93:S91-S98 https://doi.org/10.1079/BJN20041353
  79. Wasilewski A, Zielińska M, Storr M, Fichna J. 2015. Bebeficiall effects of probiotics, prebiotics, synbiotics, and phycho- biotics in inflammatory bowel disease. Inflamm Bowel Dis 21:1674-1682 https://doi.org/10.1097/MIB.0000000000000364
  80. Whelan K, Quigley EMM. 2013. Probiotics in the management of irritable bowel syndrome and inflammatory bowel disease. Curr Opin Gastroenterol 29:184-189 https://doi.org/10.1097/MOG.0b013e32835d7bba
  81. World Health Organization [WHO]. 2002. Diet, Nutrition, and the Prevention of Chronic Diseases. WHO Technical Report Series No 797
  82. Won TJ, Kim B, Lim YT, Song DS, Park SY, Park ES, Lee DI, Hwang KW. 2011. Oral administration of Lactobacillus strains from kimchi inhibits atopic dermatitis in NC/Nga mice. J Appl Microbiol 110:1195-1202 https://doi.org/10.1111/j.1365-2672.2011.04981.x
  83. Wong AHK, Mine Y. 2004. Novel fibrinolytic enzyme in fermented shrimp paste, a traditional Asian fermented seasoning. J Agric Food Chem 52:980-986 https://doi.org/10.1021/jf034535y
  84. Wong CGT, Bottiglieri T, Snead OC. 2003. GABA, ${\gamma}$-hydroxybutyric acid, and neurological disease. Ann Neurol 54: S3-S12
  85. Yoon JY, Jung KO, Kim SH, Park KY. 2004. Antiobesity effect of baek-kimchi (whitish baechu kimchi) in rats fed high diet. J Food Sci Nutr 9:259-264
  86. Yoon JA, Shin KO. 2017a. Prebiotics: A review. Korean J Food Nutr 30:191-202 https://doi.org/10.9799/ksfan.2017.30.2.191
  87. Yoon JA, Shin KO. 2017b. Studies on the function of lactic acid bacteria and related yeasts in probiotics: A review. Korean J Food Nutr 30:395-404
  88. Zhao JR, Cheng SM, Hong WD, Wang RL, Li CH. 2014. Isolation, identification, and fermentation properties of lactic acid bacteria from air dried and fermented Megalobrama amblycephala. Modern Food Sci Technol 30:100-105