Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제44권3호
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  • Pages.103-106
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  • 2018
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
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Comparison of the efficacy of amoxicillin-clavulanic acid with metronidazole to azithromycin with metronidazole after surgical removal of impacted lower third molar to prevent infection

  • Sayd, Shermil (Department of Oral and Maxillofacial Surgery, Kannur Dental College, Anjarakandy Integrated Campus) ;
  • Vyloppilli, Suresh (Department of Oral and Maxillofacial Surgery and Dentistry, Malankara Orthodox Syrian Church Medical College & Hospital) ;
  • Kumar, Krishna (Department of Cleft and Craniomaxillofacial Surgery, Aster MIMS Hospital) ;
  • Subash, Pramod (Department of Craniomaxillofacial Surgery, Amrita School of Dentistry) ;
  • Kumar, Nithin (Department of Oral and Maxillofacial Surgery, KMCT Dental College) ;
  • Raseel, Sarfras (Department of Oral and Maxillofacial Surgery, KMCT Dental College)
  • 투고 : 2017.09.30
  • 심사 : 2018.01.22
  • 발행 : 2018.06.30
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초록

Objectives: The goal of the study was to investigate the clinical effects of amoxicillin-clavulanic acid (500+125 mg) with metronidazole 400 mg administered three times daily (Group I) versus azithromycin 500 mg administered once daily and with metronidazole 400 mg three times daily (Group II) for the prevention of postoperative infection following mandibular third molar surgical removal. Materials and Methods: The study design was a single-center prospective study. Patients who reported to the Department of Oral and Maxillofacial Surgery between February 2015 and January 2017 for removal of mandibular third molar were screened, and 108 patients were chosen. One surgeon carried out all procedures. Patients were prescribed antibiotics until the two groups contained a similar number of cases. Results: Our data showed that Group II had fewer incidences of surgical site infection, but with no statistical significance. Conclusion: Although both treatments are used routinely after removal of the mandibular third molar, neither is significantly better than the other.

키워드

참고문헌

  1. Ortega G, Rhee DS, Papandria DJ, Yang J, Ibrahim AM, Shore AD, et al. An evaluation of surgical site infections by wound classification system using the ACS-NSQIP. J Surg Res 2012;174:33-8. https://doi.org/10.1016/j.jss.2011.05.056
  2. Ramu C, Padmanabhan TV. Indications of antibiotic prophylaxis in dental practice: review. Asian Pac J Trop Biomed 2012;2:749-54. https://doi.org/10.1016/S2221-1691(12)60222-6
  3. Lacasa JM, Jimenez JA, Ferras V, Bossom M, Sola-Morales O, Garcia-Rey C, et al. Prophylaxis versus pre-emptive treatment for infective and inflammatory complications of surgical third molar removal: a randomized, double-blind, placebo-controlled, clinical trial with sustained release amoxicillin/clavulanic acid (1000/62.5 mg). Int J Oral Maxillofac Surg 2007;36:321-7. https://doi.org/10.1016/j.ijom.2006.11.007
  4. Graziani F, Corsi L, Fornai M, Antonioli L, Tonelli M, Cei S, et al. Clinical evaluation of piroxicam-FDDF and azithromycin in the prevention of complications associated with impacted lower third molar extraction. Pharmacol Res 2005;52:485-90. https://doi.org/10.1016/j.phrs.2005.07.009
  5. Arteagoitia I, Diez A, Barbier L, Santamaria G, Santamaria J. Efficacy of amoxicillin/clavulanic acid in preventing infectious and inflammatory complications following impacted mandibular third molar extraction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100:e11-8. https://doi.org/10.1016/j.tripleo.2005.03.025
  6. Ren YF, Malmstrom HS. Effectiveness of antibiotic prophylaxis in third molar surgery: a meta-analysis of randomized controlled clinical trials. J Oral Maxillofac Surg 2007;65:1909-21. https://doi.org/10.1016/j.joms.2007.03.004
  7. Richardson DT, Dodson TB. Risk of periodontal defects after third molar surgery: an exercise in evidence-based clinical decisionmaking. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100:133-7. https://doi.org/10.1016/j.tripleo.2005.02.063
  8. Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation 2007;116:1736-54. https://doi.org/10.1161/CIRCULATIONAHA.106.183095
  9. Halpern LR, Dodson TB. Does prophylactic administration of systemic antibiotics prevent postoperative inflammatory complications after third molar surgery? J Oral Maxillofac Surg 2007;65:177-85. https://doi.org/10.1016/j.joms.2006.10.016
  10. Poeschl PW, Eckel D, Poeschl E. Postoperative prophylactic antibiotic treatment in third molar surgery--a necessity? J Oral Maxillofac Surg 2004;62:3-8; discussion 9. https://doi.org/10.1016/S0278-2391(04)00911-5
  11. Chuang SK, Perrott DH, Susarla SM, Dodson TB. Risk factors for inflammatory complications following third molar surgery in adults. J Oral Maxillofac Surg 2008;66:2213-8. https://doi.org/10.1016/j.joms.2008.06.067
  12. Yoshii T, Hamamoto Y, Muraoka S, Kohjitani A, Teranobu O, Furudoi S, et al. Incidence of deep fascial space infection after surgical removal of the mandibular third molars. J Infect Chemother 2001;7:55-7. https://doi.org/10.1007/s101560170036
  13. Susarla SM, Sharaf B, Dodson TB. Do antibiotics reduce the frequency of surgical site infections after impacted mandibular third molar surgery? Oral Maxillofac Surg Clin North Am 2011;23:541-6, vi. https://doi.org/10.1016/j.coms.2011.07.007
  14. Addy LD, Martin MV. Azithromycin and dentistry: a useful agent? Br Dent J 2004;197:141-3; discussion 138. https://doi.org/10.1038/sj.bdj.4811530
  15. Blakey GH, Marciani RD, Haug RH, Phillips C, Offenbacher S, Pabla T, et al. Periodontal pathology associated with asymptomatic third molars. J Oral Maxillofac Surg 2002;60:1227-33. https://doi.org/10.1053/joms.2002.35717
  16. Ishihama K, Kimura T, Yasui Y, Komaki M, Ota Y. Azithromycin as prophylaxis for the prevention of postoperative infection in impacted mandibular third-molar surgery. J Infect Chemother 2006;12:31-5. https://doi.org/10.1007/s10156-005-0419-6
  17. Delilbasi C, Saracoglu U, Keskin A. Effects of 0.2% chlorhexidine gluconate and amoxicillin plus clavulanic acid on the prevention of alveolar osteitis following mandibular third molar extractions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;94:301-4. https://doi.org/10.1067/moe.2002.125200
  18. Yoshii T, Hamamoto Y, Muraoka S, Furudoi S, Komori T. Differences in postoperative morbidity rates, including infection and dry socket, and differences in the healing process after mandibular third molar surgery in patients receiving 1-day or 3-day prophylaxis with lenampicillin. J Infect Chemother 2002;8:87-93. https://doi.org/10.1007/s101560200012
  19. Bulut E, Bulut S, Etikan I, Koseoglu O. The value of routine antibiotic prophylaxis in mandibular third molar surgery: acute-phase protein levels as indicators of infection. J Oral Sci 2001;43:117-22. https://doi.org/10.2334/josnusd.43.117
  20. Piecuch JF, Arzadon J, Lieblich SE. Prophylactic antibiotics for third molar surgery: a supportive opinion. J Oral Maxillofac Surg 1995;53:53-60. https://doi.org/10.1016/0278-2391(95)90502-2
  21. Peterson LJ. Antibiotic prophylaxis against wound infections in oral and maxillofacial surgery. J Oral Maxillofac Surg 1990;48:617-20. https://doi.org/10.1016/S0278-2391(10)80477-X
  22. Monaco G, Staffolani C, Gatto MR, Checchi L. Antibiotic therapy in impacted third molar surgery. Eur J Oral Sci 1999;107:437-41. https://doi.org/10.1046/j.0909-8836.1999.eos107604.x
  23. Thomas DW, Hill CM. An audit of antibiotic prescribing in third molar surgery. Br J Oral Maxillofac Surg 1997;35:126-8. https://doi.org/10.1016/S0266-4356(97)90688-4

피인용 문헌

  1. A systematic review of latest evidence for antibiotic prophylaxis and therapy in oral and maxillofacial surgery vol.47, pp.4, 2018, https://doi.org/10.1007/s15010-019-01303-8
  2. Treatment of intractable orofacial infection: Case reports vol.43, pp.4, 2019, https://doi.org/10.21851/obr.43.04.201912.327