The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지
DOI QR코드

DOI QR Code

A Case Report of Chemotherapy-Induced Hand-Foot Syndrome Treated with Modified Dohongsamul-tang

가미도홍사물탕 약욕요법 이후 호전된 항암화학요법 유발 수족증후군 1례

  • Received : 2018.03.16
  • Accepted : 2018.05.31
  • Published : 2018.05.30
Download PDF
⟨ Previous Next ⟩

Abstract

Hand-foot syndrome (HFS) frequently occurs after receiving chemotherapy, such as sorafenib, in patients with hepatocellular carcinoma (HCC), and this impairs quality of life (QOL). The prevalence of HFS due to sorafenib is 10-28%. The effective methods to treat HFS are not established aside from temporary discontinuation of chemotherapy agents and drug dosage adjustment because the mechanism of HFS has not been elucidated. According to a previous study, modified Dohongsamul-tang was effective in the treatment of patients with HFS and improved patients' QOL. Based on these results, we administered the soaking method with modified Dohongsamul-tang to a 50-year-old male patient with HCC complaining of HFS due to sorafenib. After two weeks, the symptoms of HFS were improved despite taking sorafenib. We suggest that modified Dohongsamul-tang is a novel method for treating HFS.

Keywords

References

  1. Abushullaih S, Saad ED, Munsell M, Hoff PM. Incidence and severity of hand-foot syndrome in colorectal cancer patients treated with capecitabine: a single-institution experience. Cancer Invest 2002; 20(1):3-10. https://doi.org/10.1081/CNV-120000360
  2. Amy SC, Linda TV. Chemotherapy-induced palmar-plantar erythrodysesthesia syndrome: etiology and emerging therapies. Support Cancer Therapy 2004;1(4):213-8. https://doi.org/10.3816/SCT.2004.n.013
  3. Zhao C, Chen J, Yu B, Wu X, Dai C, Zhou C, et al. Effect of modified taohongsiwu decoction on patients with chemotherapy-induced hand-foot syndrome. J Tradit Chin Med 2014;34(1):10-4. https://doi.org/10.1016/S0254-6272(14)60047-9
  4. Nagore E, Insa A, Sanmartin O. Antineoplastic therapy-induced palmar plantar erythrodysesthesia ('hand-foot') syndrome. Incidence, recognition and management. Am J Clin Dermatol 2000; 1(4):225-34. https://doi.org/10.2165/00128071-200001040-00004
  5. Baack BR, Burgdorf WH. Chemotherapy-induced acral erythema. J Am Acad Dermatol 1991;24(3) :457-61. https://doi.org/10.1016/0190-9622(91)70073-B
  6. Azuma Y, Hata K, Sai K, Udagawa R, Hirakawa A, Tohkin M, et al. Significant association between hand-foot syndrome and efficacy of capecitabine in patients with metastatic breast cancer. Biol Pharm Bull 2012;35(5):717-24. https://doi.org/10.1248/bpb.35.717
  7. Wehler TC, Cao Y, Galle PR, Theobald M, Moehler M, Schimanski CC. Combination therapies with oxaliplatin and oral capecitabine or intravenous 5-FU show similar toxicity profiles in gastrointestinal carcinoma patients if hand-food syndrome prophylaxis is performed continuously. Oncol Lett 2012;3(6) :1191-4. https://doi.org/10.3892/ol.2012.640
  8. von Gruenigen V, Frasure H, Fusco N, DeBernardo R, Eldermire E, Eaton S, et al. A double-blind, randomized trial of pyridoxine versus placebo for the prevention of pegylated liposomal doxorubicin-related hand-foot syndrome in gynecologic oncology patients. Cancer 2010;116(20):4735-43. https://doi.org/10.1002/cncr.25262
  9. Wolf SL, Qin R, Menon SP, Rowland KM Jr, Thomas S, Delaune R, et al. Placebo-controlled trial to determine the effectiveness of a urea/lactic acid-based topical keratolytic agent for prevention of capecitabine-induced Hand-Foot Syndrome: North central cancer treatment group study N05C5. J Clin Oncol 2010;28(35):5182-7. https://doi.org/10.1200/JCO.2010.31.1431
  10. National Cancer Institute. Common Terminology Criteria for Adverse Events(CTCAE) v.4.0, 2010. Available at http://evs.nci.nih.gov/ftp1/CTCAE/About.html)
  11. McGlynn KA, Petrick JL, London WT. Global epidemiology of hepatocellular carcinoma: an emphasis on demographic and regional variability. Clin Liver Dis 2015;19(2):223-38. https://doi.org/10.1016/j.cld.2015.01.001
  12. Grandinetti CA, Goldspiel BR. Sorafenib and sunitinib: novel targeted therapies for renal cell cancer. Pharmacotherapy 2007;27(8):1125-44. https://doi.org/10.1592/phco.27.8.1125
  13. Gridelli C, Maione P, Del Gaizo F, Colantuoni G, Guerriero C, Ferrara C, et al. Sorafenib and sunitinib in the treatment of advanced non-small cell lung cancer. Oncologist 2007;12(2):191-200. https://doi.org/10.1634/theoncologist.12-2-191
  14. Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359(4):378-90. https://doi.org/10.1056/NEJMoa0708857
  15. Lipworth AD, Robert C, Zhu AX. Hand-foot syndrome (hand-foot skin reaction, palmar-plantar erythrodysesthesia): focus on sorafenib and sunitinib. Oncology 2009;77(4):257-71. https://doi.org/10.1159/000258880
  16. Oh G. Golden Mirror of Medicine. Seoul: Daesungmoonhwasa; 1983, p. 443.
  17. Korean medicine pathological association. Pathology in Korean medicine. Seoul: Iljoongsa; 1998, p. 153, 165.
  18. Korean Herbological Association. Herbology. Seoul: Younglimsa; 1992, p. 124-5, 193-6, 302-4, 334-5, 401-2, 409-10, 412-4, 423-6, 578-83.
  19. Cho DI, Kim HS. The literature review for prescription of static blood. Daejeon University Korean Medicine Research Institute 1997;5(2) :265-79.
  20. Korean Dermatological Association. Detmatology. 3rd ed. Seoul: RyoMoonGak; 1994, p. 548.
  21. Jo SJ, ChoI YD, Jang JT, Kim KS, Lee SD. A Randomized Controlled Clinical Trial of Topical Herbal Gel Treatment for Chronic Shoulder Pain. The Acupuncture 2014;31(4):1-9. https://doi.org/10.13045/acupunct.2014048
  22. Moon WS, Lee BW, Ahn SW, Kim EH. A Historical consideration on the External Treatment theories and diseases for which medicine is efficacious. Korean Journal of Oriental Medicine 2004;10(2):1-21.
  23. Wang L, Jiao ZM, Li P. Traditional Chinese Medicine internal and external wash treatment for eight cases hand-foot syndrome caused by capecitabine. Zhong Yi Yan Jiu 2006;19(4):41-3.
  24. Cho YL, Jung HW. The effect of DohongSamulTang (DST) on immune-system in L1210 cells-transplanted mice. JPPKM 1999;13(1):132-40.
  25. Yoo BS, Jung JE, Park JY, Yoon JM, Lee I, Moon BS. Protective Effects of Dohongsamul-tang on Zinc-mediated Cytotoxicity in H9c2 Cardiomyoblast Cells. JPPKM 2004;18(5): 1374-81.
  26. Yook HS, Ahn SY, Doo HG. The Effects Of Geumguesingitang And Dohongsamultang On Rats With Nephrosis Induced By Puromycin Aminonucleoside. Journal of Korean Medicine 1997;18(2):283-315.
  27. Shin DC, Kim YG. The Study on the Effect of Dohongsamultang and Dansameum on Restrain of Thorombus Formation. Korean J Orient Int Med 1995;16(2):136-45.

Cited by

  1. 도홍사물탕(桃紅四物湯)이 골절 유합에 미치는 실험적 연구 vol.30, pp.2, 2018, https://doi.org/10.18325/jkmr.2020.30.2.47
  2. 항암 치료 후 발생한 수족증후군에 대한 한의학적 치료의 효과에 대한 고찰 vol.42, pp.3, 2018, https://doi.org/10.22246/jikm.2021.42.3.340