Korean Circulation Journal

  • 제48권3호
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  • Pages.227-229
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  • 2018
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
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Emerging Role of Aldosterone in Mediating the Vicious Cycle of Obesity, Insulin Resistance and Metabolic Syndrome

  • Park, Sungha (Division of Cardiology, Severance Cardiovascular Hospital and Cardiovascular Research Institute, Yonsei University College of Medicine)
  • 투고 : 2018.01.03
  • 심사 : 2018.03.02
  • 발행 : 2018.03.19
⟨ 이전 논문 다음 논문 ⟩

초록

키워드

참고문헌

  1. Conn JW. Hypertension, the potassium ion and impaired carbohydrate tolerance. N Engl J Med 1965;273:1135-43. https://doi.org/10.1056/NEJM196511182732106
  2. Sowers JR, Whaley-Connell A, Epstein M. Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension. Ann Intern Med 2009;150:776-83. https://doi.org/10.7326/0003-4819-150-11-200906020-00005
  3. Luther JM. Effects of aldosterone on insulin sensitivity and secretion. Steroids 2014;91:54-60. https://doi.org/10.1016/j.steroids.2014.08.016
  4. Selvaraj J, Sathish S, Mayilvanan C, Balasubramanian K. Excess aldosterone-induced changes in insulin signaling molecules and glucose oxidation in gastrocnemius muscle of adult male rat. Mol Cell Biochem 2013;372:113-26. https://doi.org/10.1007/s11010-012-1452-2
  5. Yamashita R, Kikuchi T, Mori Y, et al. Aldosterone stimulates gene expression of hepatic gluconeogenic enzymes through the glucocorticoid receptor in a manner independent of the protein kinase B cascade. Endocr J 2004;51:243-51. https://doi.org/10.1507/endocrj.51.243
  6. Lastra G, Whaley-Connell A, Manrique C, et al. Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat. Am J Physiol Endocrinol Metab 2008;295:E110-6. https://doi.org/10.1152/ajpendo.00258.2007
  7. Goodfriend TL, Ball DL, Egan BM, Campbell WB, Nithipatikom K. Epoxy-keto derivative of linoleic acid stimulates aldosterone secretion. Hypertension 2004;43:358-63. https://doi.org/10.1161/01.HYP.0000113294.06704.64
  8. Catena C, Lapenna R, Baroselli S, et al. Insulin sensitivity in patients with primary aldosteronism: a follow-up study. J Clin Endocrinol Metab 2006;91:3457-63. https://doi.org/10.1210/jc.2006-0736
  9. Wu VC, Chueh SJ, Chen L, et al. Risk of new-onset diabetes mellitus in primary aldosteronism: a population study over 5 years. J Hypertens 2017;35:1698-708. https://doi.org/10.1097/HJH.0000000000001361
  10. Kumagai E, Adachi H, Jacobs DR Jr, et al. Plasma aldosterone levels and development of insulin resistance: prospective study in a general population. Hypertension 2011;58:1043-8. https://doi.org/10.1161/HYPERTENSIONAHA.111.180521
  11. Min SH, Kim SH, Jeong IK, et al. Independent association of serum aldosterone level with metabolic syndrome and insulin resistance in Korean adults. Korean Circ J 2018;48:198-208. https://doi.org/10.4070/kcj.2017.0200