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Two different KIT mutations may lead to different responses to imatinib in metastatic gastrointestinal stromal tumor

  • Yim, Eunjung (Department of Internal Medicine, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea) ;
  • An, Ho Jung (Department of Internal Medicine, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea) ;
  • Cho, Uiju (Department of Pathology, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea) ;
  • Kim, Youngwoo (Department of Internal Medicine, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea) ;
  • Kim, Seung Hoon (Department of Internal Medicine, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea) ;
  • Choi, Yeon-Geun (Department of Internal Medicine, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea) ;
  • Shim, Byoung Yong (Department of Internal Medicine, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea)
  • Received : 2015.08.31
  • Accepted : 2015.10.15
  • Published : 2018.03.01

Abstract

Keywords

References

  1. Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med 2006;130:1466-1478.
  2. Heinrich MC, Corless CL, Demetri GD, et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 2003;21:4342-4349. https://doi.org/10.1200/JCO.2003.04.190
  3. Andersson J, Sjogren H, Meis-Kindblom JM, Stenman G, Aman P, Kindblom LG. The complexity of KIT gene mutations and chromosome rearrangements and their clinical correlation in gastrointestinal stromal (pacemaker cell) tumors. Am J Pathol 2002;160:15-22. https://doi.org/10.1016/S0002-9440(10)64343-X
  4. Corless CL, McGreevey L, Town A, et al. KIT gene deletions at the intron 10-exon 11 boundary in GI stromal tumors. J Mol Diagn 2004;6:366-370. https://doi.org/10.1016/S1525-1578(10)60533-8
  5. Dufresne A, Alberti L, Brahmi M, et al. Impact of KIT exon 10 M541L allelic variant on the response to imatinib in aggressive fibromatosis: analysis of the desminib series by competitive allele specific Taqman PCR technology. BMC Cancer 2014;14:632. https://doi.org/10.1186/1471-2407-14-632

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