DOI QR코드

DOI QR Code

Retrospective Study about the Effectiveness of Topical Preparations Containing 12 Herbal Extracts on Atopic Dermatitis Patients

선태, 백지 외 10종 한약재 추출물 함유 외용한약의 아토피 피부염 치료효과에 대한 후향적 연구

  • Received : 2018.03.13
  • Accepted : 2018.05.11
  • Published : 2018.05.25

Abstract

Objectives : The purpose of this study is to examine whether the topical preparations containing 12 herbal extracts is effective for patients with atopic dermatitis. Methods : We retrospectively reviewed the medical records of 11 patients who were prescribed topical preparations containing 12 herbal extracts on the outpatient clinic of 4 hospitals; Noble Korean Medicine Clinic, Amar Korean Medicine Clinic, Chung-Yeon Korean Medical Hospital, Donggwangju Chung-Yeon Korean Medical Hospital. Results and Conclusions : A total of 11 patients were included in the selection and exclusion criteria. The OSI mean value before treatment and at the last treatment day decreased significantly from $37.03{\pm}16.75$ to $13.32{\pm}9.83$, and the mean value of EASI decreased from $13.33{\pm}12.85$ to $2.78{\pm}5.00$, which was statistically significant. No safety concerns were reported. The results of this study confirmed the possibility that the topical preparations can be effective in moderate to severe infants, adolescents, and adult atopic dermatitis patients.

Keywords

References

  1. Zheng T, Yu J, Oh MH, Zhu Z. The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma. Allergy, asthma & immunology research. 2011;3(2):67-73. https://doi.org/10.4168/aair.2011.3.2.67
  2. Kangmo Ahn. The Prevalence of Atopic Dermatitis in Korean Children. Allergy Asthma Immunol Res. 2016;8(1):1-2. https://doi.org/10.4168/aair.2016.8.1.1
  3. Kim BK, Kim JY, Kang MK, Yang MS, Park HW, Min KU, et al. Allergies are still on the rise? A 6-year nationwide population-based study in Korea. Allergol Int. 2016;65(2): 186-91. https://doi.org/10.1016/j.alit.2015.11.002
  4. Leung DY, Guttman-Yassky E. Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches. The Journal of allergy and clinical immunology. 2014;134(4):769-79. https://doi.org/10.1016/j.jaci.2014.08.008
  5. Korea Institute of Oriental Medicine. Atopic Dermatitis Korean Medicine Clinical Practice Guideline. Seoul:Elsevier Korea. 2015.
  6. Kim HY, Roh SS. The Assessment of Risk of Bias of Clinical Trials on Herbal Externals for Atopic Dermatitis. Journal of the Graduate School, Taejon University. 2016;18(2):1-16.
  7. Ahn JH. Efficacy and safety of topical Jaungo application in patients with atopic dermatitis: a randomized, double-blind, placebo-controlled study. Kyung Hee University. 2017.
  8. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh)(suppl). 1980;92:44-7.
  9. Choi SY, Park KY, Li KS, Seo SJ, Kim KH, Kim DW, et al. Comparison of Severity Scoring Systems of Atopic Dermatitis. Korean J Dermatol. 2013;51(4):243-8.
  10. Kim KW, Cho HB, Kim SB, Choe CM, Seo YJ. The anti-inflammatory effects of Cicadidae Periostracum. The Jounal of Oriental Obstetrics&Gynecology. 2011;24(1):15-26.
  11. Ahn JH, KIM KJ. Effects of Cryptotympana pustulata on the expression of cytokine genes in human monocytes of THP-1. J Korean Med Ophthalmol Otolaryngol Dermatol. 2010;23(1):94-110.
  12. Chang YJ, Jung DL, Hong SU. The effect of Periostracum Cicadae on capsaicin-induced model of atopic dermatitis in rats. J Korean Med Ophthalmol Otolaryngol Dermatol. 2015;28(4):41-50. https://doi.org/10.6114/JKOOD.2015.28.4.041
  13. Leem KH, Kim MG, Lee SN, Lim JP. Effect of Angelicae Dahuricae Radix on Expression of Cytokines and Chemokines Levels in Human Mast Cells (HMC). Kor J Herbology. 2007;22(1):81-7.
  14. Vinatoru M. An overview of the ultrasonically assisted extraction of bioactive principles from herbs. Ultrasonics Sonochemistry. 2001;8(3):303-13. https://doi.org/10.1016/S1350-4177(01)00071-2
  15. Yeo EJ, Han KJ, Kim YH. Topical Application of Atopy cream-Jawoongo ointment(A-J) of Ointment Inhibits Biostir mite antigen cream induced Atopy Dermatitis by Local Action in NC/Nga Mice. Journal of Haehwa Medicine. 2008;7(2):185-98.