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A comparison study of the effects of loratadine-pharmacopuncture and loratadine-oral administration based on traditional Korean medicine theory on anaphylactic reaction in mice

  • Kim, Hyun-Min (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Hyun-Min (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Min-Jung (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Cho, Min-Gi (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Kang, Deok (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Yu-Kyung (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Changmin (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Kang, Do-Hyun (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Jeong, Si-Hwa (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Ahn, Ik-Gyun (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Hwang, Jun-Hyeok (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Jae-Hyun (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Hyun-Jin (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Jang, Jun-Yeong (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Park, Ho-Jung (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Kang, Sin woo (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Youm, Jieun (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Baek, Seung-won (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Eu Jin (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Shin, Moon-Kou (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Park, Chan (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Son, Chang-Bin (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Yim, Tae-Bin (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Lim, Jung Hyun (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Hong, Sung-eun (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Choi, Jun-Hyuk (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Jun-Dong (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Yoon, Dong-ju (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Dong-Min (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Yu, Soo-Min (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Hong, Ye-Im (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Yeong-Seok (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Koo, Bon-Cheol (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Park, Hyoung-Jun (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Uem, Chae-Yoon (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Min-Jeong (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Oh, Jayoung (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Park, NamGyeong (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Eun-Jong (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Cho, Whi-Sung (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Ho-Sung (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Tae-oh (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Yoon, Cheol (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Kwon, Sung-Keun (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Jeong, Dong-Hyeon (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Changwon (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Yu, Sang-Yeol (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Shon, Chae-won (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Jeon, Gyu-Ri (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Hong, Yang-Seok (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Moon, Phil-Dong (Department of Pharmacology, College of Korean Medicine, Kyung Hee University)
  • Received : 2018.02.12
  • Accepted : 2018.02.23
  • Published : 2018.02.28

Abstract

Pharmacopuncture, or herbal acupuncture, is a new form of therapy derived from combinations of two traditional therapeutic methods, herbal medicine and acupuncture therapy. To compare the efficacy between loratadine-pharmacopuncture (LP) and loratadine-oral administration (LO), the effect of loratadine was investigated in murine models. Anti-anaphylactic effects of loratadine treatments were investigated in compound 48/80-induced systemic anaphylactic reaction and passive cutaneous anaphylaxis (PCA). LP treatment significantly inhibited the compound 48/80-induced systemic anaphylactic reaction and PCA. The effect between LP and LO were on a similar level. These results indicate that LP can be used as an alternative method for LO in case of emergency.

Keywords

References

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