Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Comparison of Cognitive Controls in Patients with Bipolar I Disorder and Their Unaffected First-Degree Relatives

양극성 I형 장애 환자와 발병하지 않은 일차 친족에서 인지조절의 비교

  • Yun, Hyerim (Department of Psychiatry, School of Medicine, Kyungpook National University) ;
  • Woo, Seonjin (Department of Psychiatry, School of Medicine, Kyungpook National University) ;
  • Lee, Sang-Won (Department of Psychiatry, School of Medicine, Kyungpook National University) ;
  • Jin, Bo-Hyun (Department of Psychiatry, School of Medicine, Kyungpook National University) ;
  • Woo, Jungmin (Department of Psychiatry, School of Medicine, Kyungpook National University) ;
  • Won, Seunghee (Department of Psychiatry, School of Medicine, Kyungpook National University)
  • 윤혜림 (경북대학교 의학전문대학 정신건강의학교실) ;
  • 우선진 (경북대학교 의학전문대학 정신건강의학교실) ;
  • 이상원 (경북대학교 의학전문대학 정신건강의학교실) ;
  • 진보현 (경북대학교 의학전문대학 정신건강의학교실) ;
  • 우정민 (경북대학교 의학전문대학 정신건강의학교실) ;
  • 원승희 (경북대학교 의학전문대학 정신건강의학교실)
  • Received : 2017.10.11
  • Accepted : 2017.12.26
  • Published : 2018.02.28
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Abstract

Objectives This study intended to identify the deficits of cognitive control among patients with bipolar I disorder and their first-degree relatives, and identify the possibility of cognitive control as an endophenotype of bipolar disorder. Methods The study included three groups: euthymic states patients with bipolar I disorder (n = 55), unaffected first-degree relatives of probands with bipolar I disorder (n = 30), and a healthy control group (n = 51), that was matched on age, sex, and years of education. The AX version of the continuous performance test (CPT) was used to examine cognitive control. Error rate, correct response times of each subsets (AX, BX, AY, BY), and d' as an indication of accuracy sensitivity index were calculated. Psychopathology, intelligence, and psychomotor speed were also assessed. Results Patients with bipolar I disorder showed significantly worse error rates in the AX (p = 0.01) and BX (p = 0.02) subsets and d' (p = 0.05) than the others. They also showed more delayed correct response times than the healthy control group and first-degree relatives in all subsets (p < 0.01). But first-degree relatives showed neither high error rates nor delayed correct response times than healthy control group. Conclusions These findings suggest that cognitive control is impaired in bipolar I disorder but less likely to be an endophynotype of bipolar I disorder.

Keywords

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