Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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The Roles of Frontal Cortex in Primary Insomnia : Findings from Functional Magnetic Resonance Imaging Studies

일차성 불면증에서 전두엽의 역할 : 기능적 자기공명영상 연구

  • Kim, Bori (Department of Brain and Cognitive Sciences, Ewha Womans University) ;
  • Park, Su Hyun (Department of Brain and Cognitive Sciences, Ewha Womans University) ;
  • Cho, Han Byul (Ewha Brain Institute, Ewha Womans University) ;
  • Kim, Jungyoon (Department of Brain and Cognitive Sciences, Ewha Womans University)
  • 김보리 (이화여자대학교 뇌인지과학과) ;
  • 박수현 (이화여자대학교 뇌인지과학과) ;
  • 조한별 (이화여자대학교 뇌융합과학연구원) ;
  • 김정윤 (이화여자대학교 뇌인지과학과)
  • Received : 2018.01.18
  • Accepted : 2018.01.25
  • Published : 2018.02.28
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Abstract

Insomnia is a common sleep-related symptom which occurs in many populations, however, the neural mechanism underlying insomnia is not yet known. The hyperarousal model explains the neural mechanism of insomnia to some extent, and the frontal cortex dysfunction has been known to be related to primary insomnia. In this review, we discuss studies that applied resting state and/or task-related functional magnetic resonance imaging to demonstrate the deficits/dysfunctions of functional activation and network in primary insomnia. Empirical evidence of the hyperarousal model and proposed relation between the frontal cortex and other brain regions in primary insomnia are examined. Reviewing these studies could provide critical insights regarding the pathophysiology, brain network and cerebral activation in insomnia and the development of novel methodologies for the diagnosis and treatment of insomnia.

Keywords

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