DOI QR코드

DOI QR Code

Hypercalciuria and febrile convulsion in children under 5 years old

  • Received : 2017.06.19
  • Accepted : 2018.01.12
  • Published : 2018.04.15

Abstract

Purpose: The association between hypercalciuria and febrile convulsion is controversial. The present study aimed to investigate the statistical association between hypercalciuria and childhood febrile convulsions. Methods: Overall, 160 children aged 6 months to 5 years, including 80 children with febrile convulsion and 80 febrile children without convulsion (comparison group), were recruited. All laboratory tests, including 24-hour urine calcium, were undertaken in an academic clinical laboratory. Results: Forty-five children of the febrile convulsion group (60%) and 30 of the comparison group (40%) had hypercalciuria. There was a significant difference between the 2 groups (P=0.02). Conclusion: Our results indicated that there is a statistical association between convulsion and hypercalciuria in children. Since we found this association with a cross-sectional assessment, further studies, especially prospective and controlled designs, are needed.

Keywords

References

  1. Kliegman RM, Behrman RE, Jenson HB, Stanton BF. Nelsons text book of pediatrics. 18th ed. Philadelphia (PA): Saunders Elsevier, 2007.
  2. Karbasi SA, Mosadegh MM, Fallah R. Utility of laboratory studies in seizures of children older than one month of age. Singapore Med J 2009;50:814-6.
  3. Kumar B, Kalita J, Misra UK. Febrile seizure. J Indian Med Assoc 2010;108:441-2, 451-6.
  4. Jones T, Jacobsen SJ. Childhood febrile seizures: overview and implications. Int J Med Sci 2007;4:110-4.
  5. Papadimitriou A, Nicolaidou P, Garoufi A, Georgouli H, Karpathios T. Hypercalciuria in children with febrile convulsions. Pediatr Int 2001;43:231-4. https://doi.org/10.1046/j.1442-200x.2001.01386.x
  6. Hartfield DS, Tan J, Yager JY, Rosychuk RJ, Spady D, Haines C, et al. The association between iron deficiency and febrile seizures in childhood. Clin Pediatr (Phila) 2009;48:420-6. https://doi.org/10.1177/0009922809331800
  7. Daoud AS, Batieha A, Abu-Ekteish F, Gharaibeh N, Ajlouni S, Hijazi S. Iron status: a possible risk factor for the first febrile seizure. Epilepsia 2002;43:740-3. https://doi.org/10.1046/j.1528-1157.2002.32501.x
  8. Santos F, Suarez D, Malaga S, Crespo M. Idiopathic hypercalciuria in children: pathophysiologic considerations of renal and absorptive subtypes. J Pediatr 1987;110:238-43. https://doi.org/10.1016/S0022-3476(87)80161-0
  9. Srivastava T, Schwaderer A. Diagnosis and management of hypercalciuria in children. Curr Opin Pediatr 2009;21:214-9. https://doi.org/10.1097/MOP.0b013e3283223db7
  10. Bose A, Monk RD, Bushinsky DA. Kidney stones. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, editors. Williams textbook of endocrinology. 13th ed. Philadelphia (PA): Elsevier, 2016:1365-84.
  11. Chiarelli F, De Palma C, Verrotti A, Lombardi G, Domizio S. Electrolytic changes in febrile convulsions. Pediatr Med Chir 1985;7:249-52.
  12. Amouian S, Mohammadian S, Behnampour N, Tizrou M. Trace elements in febrile seizure compared to febrile children admitted to an academic hospital in iran, 2011. J Clin Diagn Res 2013;7:2231-3.
  13. Mohammadi J. Biochemical disorders in children with febrile seizure. J Ilam Univ Med Sci 2007;16:25-31.
  14. Honarpisheh A, Hooman N, Taghavi A. Urinary calcium excretion in healthy children living in Kashan/Iran. Iran J Pediatr 2009:19:154-8.