Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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The association of total blood mercury levels and overweight among Korean adolescents: analysis of the Korean National Health and Nutrition Examination Survey (KNHANES) 2010-2013

  • Shin, Yi-Yeon (Department of Pediatrics, Inje University Sanggye Paik Hospital) ;
  • Ryu, In-Kyung (Department of Pediatrics, Inje University Sanggye Paik Hospital) ;
  • Park, Mi-Jung (Department of Pediatrics, Inje University Sanggye Paik Hospital) ;
  • Kim, Shin-Hye (Department of Pediatrics, Inje University Sanggye Paik Hospital)
  • Received : 2017.09.11
  • Accepted : 2017.10.25
  • Published : 2018.04.15
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Abstract

Purpose: Obesity has been associated with higher total blood mercury levels, based on animal studies; however, studies that focus on children and adolescents are lacking. We aimed to assess the association between total blood mercury levels and the incidence of overweight and abdominal obesity in Korean adolescents. Methods: The study population comprised 1,567 adolescents (793 boys and 774 girls; aged 10-19 years), who participated in the Korea National Health and Nutrition Examination Survey 2010-2013. We analyzed total blood mercury levels according to obesity status in all participants. Results: The geometric mean of total blood mercury levels was $1.93{\mu}g/L$. Participants with overweight ($2.20{\mu}g/L$) and obesity ($2.17{\mu}g/L$) had higher levels than those with normal weight ($1.86{\mu}g/L$, P<0.0001). The prevalence of overweight significantly increased with elevation of the total blood mercury quartile in both sexes. Increased incidence of abdominal obesity corresponding to increased total blood mercury level was observed in boys. After adjusting for covariates, those in the highest total blood mercury quartile were found to be at higher risk of overweight/obesity than those in the lowest quartile in both sexes (odds ratio [95% confidence interval]: boys, 3.27 [1.66-6.41]; girls, 1.90 [1.03-3.49]). The association between total blood mercury quartile and abdominal obesity was significant after controlling for covariates in boys (2.35 [1.05-5.24]). Conclusion: Our results suggest an association between total blood mercury levels and overweight in Korean adolescents.

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References

  1. UNEP(United Nations Environment Programme). Global Mercury Assessment 2013: Sources, Emissions, Releases and Environmental Transport [Internet]. Switzerland: UNEP Chemicals Branch Geneva; c2013 [cited 2017 Jun 1]. Available from: http://wedocs.unep.org//handle/20.500.11822/7984.
  2. Tan SW, Meiller JC, Mahaffey KR. The endocrine effects of mercury in humans and wildlife. Crit Rev Toxicol 2009;39:228-69. https://doi.org/10.1080/10408440802233259
  3. Chen YW, Huang CF, Tsai KS, Yang RS, Yen CC, Yang CY, et al. The role of phosphoinositide 3-kinase/Akt signaling in low-dose mercuryinduced mouse pancreatic beta-cell dysfunction in vitro and in vivo. Diabetes 2006;55:1614-24. https://doi.org/10.2337/db06-0029
  4. Lee S, Yoon JH, Won JU, Lee W, Lee JH, Seok H, et al. The association between blood mercury levels and risk for overweight in a general adult population: results from the Korean National Health and Nutrition Examination Survey. Biol Trace Elem Res 2016;171:251-61. https://doi.org/10.1007/s12011-015-0530-1
  5. Park JS, Ha KH, He K, Kim DJ. Association between blood mercury level and visceral adiposity in adults. Diabetes Metab J 2017;41:113-20. https://doi.org/10.4093/dmj.2017.41.2.113
  6. Skalnaya MG, Tinkov AA, Demidov VA, Serebryansky EP, Nikonorov AA, Skalny AV. Hair toxic element content in adult men and women in relation to body mass index. Biol Trace Elem Res 2014;161:13-9. https://doi.org/10.1007/s12011-014-0082-9
  7. Lee BK, Kim Y. Blood cadmium, mercury, and lead and metabolic syndrome in South Korea: 2005-2010 Korean National Health and Nutrition Examination Survey. Am J Ind Med 2013;56:682-92. https://doi.org/10.1002/ajim.22107
  8. Fan Y, Zhang C, Bu J. Relationship between selected serum metallic elements and obesity in children and adolescent in the U.S. Nutrients 2017 Feb 3;9(2). pii: E104. https://doi.org/10.3390/nu9020104.
  9. Rothenberg SE, Korrick SA, Fayad R. The influence of obesity on blood mercury levels for U.S. non-pregnant adults and children: NHANES 2007-2010. Environ Res 2015;138:173-80. https://doi.org/10.1016/j.envres.2015.01.018
  10. World Health Oraganization. Children's exposure to mercury compounds [Internet]. Geneva (Switzerland): World Health Oraganization; c2010 [cited 2016 Nov 6]. Available from: http://who.int/ceh/publications/children_exposure/en/.
  11. Moon JS, Lee SY, Nam CM, Choi JM, Choe BK, Seo JW, et al. 2007 Korean National Growth Charts: review of developmental process and an outlook. Korean J Pediatr 2008;51:1-25. https://doi.org/10.3345/kjp.2008.51.1.1
  12. World Health Oraganization. The Asia-Pacific perspective: redefining obesity and its treatment [Internet]. Sydney (Australia): Health Communications Australia; c2000 [cited 2017 Apr 5]. Available from: http://iris.wpro.who.int/handle/10665.1/5379.
  13. Yoo EG. Waist-to-height ratio as a screening tool for obesity and cardiometabolic risk. Korean J Pediatr 2016;59:425-31. https://doi.org/10.3345/kjp.2016.59.11.425
  14. World Health Oraganization. Iron deficiency anaemia: assessment, prevention and control: a guide for programme managers [Internet]. Geneva (Switzerland): World Health Oraganization; c2014 [cited 2017 Apr 4] Available from: http://www.who.int/nutrition/publications/en/ida_assessment_prevention_control.pdf.
  15. Ilmiawati C, Yoshida T, Itoh T, Nakagi Y, Saijo Y, Sugioka Y, et al. Biomonitoring of mercury, cadmium, and lead exposure in Japanese children: a cross-sectional study. Environ Health Prev Med 2015;20:18-27. https://doi.org/10.1007/s12199-014-0416-4
  16. Chen G, Chen X, Yan C, Wu X, Zeng G. Surveying mercury levels in hair, blood and urine of under 7-year old children from a coastal city in China. Int J Environ Res Public Health 2014;11:12029-41. https://doi.org/10.3390/ijerph111112029
  17. Lye E, Legrand M, Clarke J, Probert A. Blood total mercury concentrations in the Canadian population: Canadian Health Measures Survey cycle 1, 2007-2009. Can J Public Health 2013;104:e246-51. https://doi.org/10.17269/cjph.104.3772
  18. Mortensen ME, Caudill SP, Caldwell KL, Ward CD, Jones RL. Total and methyl mercury in whole blood measured for the first time in the U.S. population: NHANES 2011-2012. Environ Res 2014;134:257-64. https://doi.org/10.1016/j.envres.2014.07.019
  19. Schulz C, Angerer J, Ewers U, Heudorf U, Wilhelm M; Human Biomonitoring Commission of the German Federal Environment Agency. Revised and new reference values for environmental pollutants in urine or blood of children in Germany derived from the German environmental survey on children 2003-2006 (GerES IV). Int J Hyg Environ Health 2009;212:637-47. https://doi.org/10.1016/j.ijheh.2009.05.003
  20. Kim BG, Jo EM, Kim GY, Kim DS, Kim YM, Kim RB, et al. Analysis of methylmercury concentration in the blood of Koreans by using cold vapor atomic fluorescence spectrophotometry. Ann Lab Med 2012;32:31-7. https://doi.org/10.3343/alm.2012.32.1.31
  21. AIST Research Center for CRM. 2007. Japanese exposure factors handbook [Internet]. Tsukuba (Japan): National Institute of Advanced Industrial Science and Technology; c2007 [cited 2017 Jun 9]. Available from: https://unit.aist.go.jp/riss/crm/exposurefactors/english_summary.html.
  22. Jang JY, Jo SN, Kim SJ, Myung HN, Kim CI. Food ingestion factors of the Korean exposure factors handbook. J Prev Med Public Health 2014;47:18-26. https://doi.org/10.3961/jpmph.2014.47.1.18
  23. Duan X, Zhao X, Wang B, Chen Y, Cao S. Highlights of the Chinese exposure factors handbookv(Adult). Waltham (MA): Academic Press (Elsevier), 2015:28.
  24. U. S. Environmental Protection Agency. Exposure Factors Handbook: Chapter 10. Intake of Fish and Shellfish. In: Exposure factors handbook 2011 edition (Final report) [Internet]. Washington, DC: U.S. Environmental Protection Agency; c2011 [cited 2017 Jun 5]. Available from: https://www.epa.gov/sites/production/files/2015-09/documents/efh-chapter10.pdf.
  25. Agriculture and Agri-Food Canada. Per capita disappearance: protein disappearance of animal protein sources in Canada [Internet]. Canada: Agriculture and Agri-Food Canada; c2017 [cited 2017 Jun 29]. Available from: http://www.agr.gc.ca/eng/industry-markets-andtrade/market-information-by-sector/poultry-and-eggs/poultry-andegg-market-information/industry-indicators/per-capita-disappearance/?id=1384971854413.
  26. European Commission's Joint Research Centre. The European exposure factors: Database access: Consumption of cooked meat and fish [Internet]. European Commission; c2002 [cited 2017 Jun 9]. Available from: http://expofacts.jrc.ec.europa.eu/index.php?category=database&source=results&.
  27. Moon SS. Additive effect of heavy metals on metabolic syndrome in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010. Endocrine 2014;46:263-71. https://doi.org/10.1007/s12020-013-0061-5
  28. You CH, Kim BG, Kim JM, Yu SD, Kim YM, Kim RB, et al. Relationship between blood mercury concentration and waist-to-hip ratio in elderly Korean individuals living in coastal areas. J Prev Med Public Health 2011;44:218-25. https://doi.org/10.3961/jpmph.2011.44.5.218
  29. Vahter ME, Mottet NK, Friberg LT, Lind SB, Charleston JS, Burbacher TM. Demethylation of methyl mercury in different brain sites of Macaca fascicularis monkeys during long-term subclinical methyl mercury exposure. Toxicol Appl Pharmacol 1995;134:273-84. https://doi.org/10.1006/taap.1995.1193
  30. Yamamoto M, Yanagisawa R, Motomura E, Nakamura M, Sakamoto M, Takeya M, et al. Increased methylmercury toxicity related to obesity in diabetic KK-Ay mice. J Appl Toxicol 2014;34:914-23. https://doi.org/10.1002/jat.2954
  31. Aberg B, Ekman L, Falk R, Greitz U, Persson G, Snihs JO. Metabolism of methyl mercury (203Hg) compounds in man. Arch Environ Health 1969;19:478-84. https://doi.org/10.1080/00039896.1969.10666872
  32. Geier A, Dietrich CG, Grote T, Beuers U, Prufer T, Fraunberger P, et al. Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat. J Hepatol 2005;43:1021-30. https://doi.org/10.1016/j.jhep.2005.05.031
  33. Geier DA, Kern JK, Homme KG, Sykes LK, Geier MR. Thimerosalcontaining hepatitis B vaccine exposure is highly associated with childhood obesity: a case-control study using the vaccine safety datalink. N Am J Med Sci 2016;8:297-306. https://doi.org/10.4103/1947-2714.187148
  34. Thomas DJ, Fisher HL, Sumler MR, Marcus AH, Mushak P, Hall LL. Sexual differences in the distribution and retention of organic and inorganic mercury in methyl mercury-treated rats. Environ Res 1986;41:219-34. https://doi.org/10.1016/S0013-9351(86)80184-0
  35. White UA, Tchoukalova YD. Sex dimorphism and depot differences in adipose tissue function. Biochim Biophys Acta 2014;1842:377-92. https://doi.org/10.1016/j.bbadis.2013.05.006

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