Korean Chemical Engineering Research

The Korean Institute of Chemical Engineers (한국화학공학회)
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Stability and in Vivo UV-Protecting Efficacy of Emulsions Stabilized with Cinnamoyl Surfactants

  • Park, Seok Ho (Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University) ;
  • Kwon, Kyeongnan (Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University) ;
  • Kim, Jin-Chul (Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University)
  • Received : 2017.08.15
  • Accepted : 2017.11.29
  • Published : 2018.04.01
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Abstract

Oil-in-water emulsion was prepared using cinnamoyl surfactants as emulsifiers. Cinnamoyl surfactants used in the present study were polyoxyethylene (20) sorbitan monolaurate-cinnamic acid conjugate (TW20CA), polyoxyethylene (20) cetyl ether-cinnamic acid conjugate (CE20CA), and polyoxyethylene(20) oleyl ether-cinnamic acid conjugate (OE20CA). The emulsion stabilized with TW20CA was the most stable, possibly because the polyoxyethylene segment of TW20CA would sterically stabilize the oil droplets effectively. In vivo UV protecting efficacy of surfactant and emulsion was investigated by determining the minimum amount of UV light (MAUL) to induce a black point on the back of hairless mice (HRM2). The mean MAUL of PARSOL, OE20CA, and emulsion stabilized with TW20CA was $1046.5mJ/cm^2$, $1163mJ/cm^2$, and $1308.5mJ/cm^2$, respectively. The high UV-protecting efficacy of the emulsion could be ascribed to not only the UV-absorbing property of cinnamoyl group but also the UV-scattering property of the oil droplets.

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References

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