Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Analysis of Hyaluronic Acid Microneedle Characteristics as Its Shapes

히알루론산 마이크로니들 형태에 따른 특성 분석

  • Ryu, Jong Hoon (Dept. of Biomedical Engineering, Konyang University) ;
  • Shin, Hyun Young (Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST)) ;
  • Lee, Jeong-Gun (S-Skin Co., Ltd.) ;
  • Tae, Ki-Sik (Dept. of Biomedical Engineering, Konyang University) ;
  • Kim, Minseok S. (Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST))
  • 류종훈 (건양대학교 의공학부) ;
  • 신현영 (대구경북과학기술원 뉴바이올로지학과) ;
  • 이정건 (에스스킨) ;
  • 태기식 (건양대학교 의공학부) ;
  • 김민석 (대구경북과학기술원 뉴바이올로지학과)
  • Received : 2017.11.16
  • Accepted : 2017.12.18
  • Published : 2018.02.28
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Abstract

Conventional drug delivery methods mainly include subcutaneous injection and oral administration. Subcutaneous injection has the advantages of delivering the correct concentration, but it might cause pain and trauma to patients. Although oral administrations do not accompany pain as the subcutaneous injection, unexpected side effects may occur because they undergo digestion process and it is not easy for many drugs to be exposed to targeted sites with proper concentration. While dissolving microneedles have been extensively studied to overcome the limitations of conventional subcutaneous injection, the effects on microneedle shapes for drug release have not been fully explored. In this study, the characteristics of hyaluronic acid microneedles for cone and quadrangular pyramidal shapes were examined by the size, volume, contact surface area, skin permeability, and dissolution rate. As a result, the cone shapes of hyaluronic acid microneedles had high skin permeability, and the quadrangular pyramid of shapes hyaluronic acid microneedles showed a fast dissolution rate, given by the large contact area on the skin. Based on the results, we could confirm that the shape of a dissolving microneedles can affect skin permeability and the drug delivery rate.

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References

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