Nutrition Research and Practice

  • 제12권2호
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  • Pages.118-128
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  • 2018
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  • 1976-1457(pISSN)
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  • 2005-6168(eISSN)
한국영양학회 (The Korean Nutrition Society)
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Effects of glutathione s-transferase (GST) M1 and T1 polymorphisms on antioxidant vitamins and oxidative stress-related parameters in Korean subclinical hypertensive subjects after kale juice (Brassica oleracea acephala) supplementation

  • Lee, Hye-Jin (Department of Food and Nutrition, College of Life Science and Nano Technology, Hannam University) ;
  • Han, Jeong-Hwa (Nutrition Safety Policy Division, Ministry of Food and Drug Safety) ;
  • Park, Yoo Kyoung (Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Kang, Myung-Hee (Department of Food and Nutrition, College of Life Science and Nano Technology, Hannam University)
  • 투고 : 2017.08.03
  • 심사 : 2018.02.19
  • 발행 : 2018.04.01
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초록

BACKGROUND/OBJECTIVES: Glutathione s-transferase (GST) is involved in the formation of a multigene family comprising phase II detoxification enzymes, involved in the detoxification of reactive oxygen species. This study evaluated whether daily supplementation with kale juice could modulate levels of plasma antioxidant vitamins and oxidative stress-related parameters. We further examined whether this modulation was affected by combined GSTM1 and T1 polymorphisms. SUBJECTS/METHODS: Totally, 84 subclinical hypertensive patients having systolic blood pressure (BP) over 130 mmHg or diastolic BP over 85 mmHg, received 300 mL of kale juice daily for 6 weeks. Blood samples were drawn before start of study and after completion of 6 weeks. RESULTS: After supplementation, we observed significant decrease in DNA damage and increase in erythrocyte catalase activity in all genotypes. Plasma level of vitamin C was significantly increased in the wild/null and double null genotypes. The plasma levels of ${\beta}-carotene$, erythrocyte glutathione peroxidase activity, and nitric oxide were increased only in the wild/null genotype after kale juice supplementation. CONCLUSIONS: The effect of kale juice was significantly greater in the GSTM1 null genotype and wild/null genotype groups, suggesting possibility of personalized nutritional prescriptions based on personal genetics.

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참고문헌

  1. Oparil S, Zaman MA, Calhoun DA. Pathogenesis of hypertension. Ann Intern Med 2003;39:761-76.
  2. Harris DM, Cohn HI, Pesant S, Eckhart AD. GPCR signalling in hypertension: role of GRKs. Clin Sci (Lond) 2008;115:79-89. https://doi.org/10.1042/CS20070442
  3. Yildiz A, Gur M, Yilmaz R, Demirbag R, Celik H, Aslan M, Kocyigit A. Lymphocyte DNA damage and total antioxidant status in patients with white-coat hypertension and sustained hypertension. Turk Kardiyol Dern Ars 2008;36:231-8.
  4. Gur M, Yildiz A, Demirbag R, Yilmaz R, Kocyigit A, Celik H, Aksoy N. Relationship between left ventricle geometric patterns and lymphocyte DNA damage in patients with untreated essential hypertension. Clin Biochem 2007;40:454-9. https://doi.org/10.1016/j.clinbiochem.2006.10.024
  5. Bessa SS, Ali EM, Hamdy SM. The role of glutathione S- transferase M1 and T1 gene polymorphisms and oxidative stress-related parameters in Egyptian patients with essential hypertension. Eur J Intern Med 2009;20:625-30. https://doi.org/10.1016/j.ejim.2009.06.003
  6. Chung SY, Kim HW, Yoon S. Analysis of antioxidant nutrients in green yellow vegetable juice. Korean J Food Sci Technol 1999;31:880-6.
  7. Kim SY, Yoon S, Kwon SM, Park KS, Lee-Kim YC. Kale juice improves coronary artery disease risk factors in hypercholesterolemic men. Biomed Environ Sci 2008;21:91-7. https://doi.org/10.1016/S0895-3988(08)60012-4
  8. Kim HY, Park YK, Kim TS, Kang MH. The effect of green vegetable drink supplementation on cellular DNA damage and antioxidant status of Korean smokers. Korean J Nutr 2006;39:18-27.
  9. Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol 2005;45:51-88. https://doi.org/10.1146/annurev.pharmtox.45.120403.095857
  10. Hayes JD, Strange RC. Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology 2000;61:154-66. https://doi.org/10.1159/000028396
  11. Dusinska M, Collins AR. The comet assay in human biomonitoring: gene-environment interactions. Mutagenesis 2008;23:191-205.
  12. Wilms LC, Boots AW, de Boer VC, Maas LM, Pachen DM, Gottschalk RW, Ketelslegers HB, Godschalk RW, Haenen GR, van Schooten FJ, Kleinjans JC. Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers. Carcinogenesis 2007;28:1800-6. https://doi.org/10.1093/carcin/bgm145
  13. Lampe JW, Chen C, Li S, Prunty J, Grate MT, Meehan DE, Barale KV, Dightman DA, Feng Z, Potter JD. Modulation of human glutathione S-transferases by botanically defined vegetable diets. Cancer Epidemiol Biomarkers Prev 2000;9:787-93.
  14. Hakim IA, Harris RB, Chow HH, Dean M, Brown S, Ali IU. Effect of a 4-month tea intervention on oxidative DNA damage among heavy smokers: role of glutathione S-transferase genotypes. Cancer Epidemiol Biomarkers Prev 2004;13:242-9. https://doi.org/10.1158/1055-9965.EPI-03-0193
  15. Hakim IA, Chow HH, Harris RB. Green tea consumption is associated with decreased DNA damage among GSTM1-positive smokers regardless of their hOGG1 genotype. J Nutr 2008;138:1567S-1571S. https://doi.org/10.1093/jn/138.8.1567S
  16. Han JH, Lee HJ, Choi HJ, Yun KE, Kang MH. Association between oxidative stress and blood pressure in Korean subclinical hypertensive patients. Korean J Nutr 2013;46:126-36. https://doi.org/10.4163/kjn.2013.46.2.126
  17. Bell DA, Taylor JA, Paulson DF, Robertson CN, Mohler JL, Lucier GW. Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst 1993;85:1159-64.
  18. Capoluongo E, Onder G, Concolino P, Russo A, Santonocito C, Bernabei R, Zuppi C, Ameglio F, Landi F. GSTM1-null polymorphism as possible risk marker for hypertension: results from the aging and longevity study in the Sirente Geographic Area (ilSIRENTE study). Clin Chim Acta 2009;399:92-6. https://doi.org/10.1016/j.cca.2008.09.017
  19. Pesce AJ, Kaplan LA. Methods in Clinical Chemistry. St. Louis (MO): Mosby; 1987.
  20. Van Vliet T, Van Schaik F, Van Schoonhoven J, Schrijver J. Determination of several retinoids, carotenoids and E vitamers by high-performance liquid chromatography. Application to plasma and tissues of rats fed a diet rich in either beta-carotene or canthaxanthin. J Chromatogr 1991;553:179-86. https://doi.org/10.1016/S0021-9673(01)88486-7
  21. Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and convenient assay for superoxide dismutase. Eur J Biochem 1974;47:469-74. https://doi.org/10.1111/j.1432-1033.1974.tb03714.x
  22. Beutler E. Glutathione peroxidase. In: Beutler E, editor. Red Cell Metabolism: a Manual for Biochemical Methods. 3rd ed. Orlando (FL): Grune & Stratton; 1984. p. 71-3.
  23. Aebi H. Catalase. In: Bergmeyer HU, Gawehn K, editors. Methods of Enzymatic Analysis. 2nd ed. Weinheim: Academic Press; 1974. p. 673-8.
  24. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988;175:184-91. https://doi.org/10.1016/0014-4827(88)90265-0
  25. Ahotupa M, Ruutu M, Mantyla E. Simple methods of quantifying oxidation products and antioxidant potential of low density lipoproteins. Clin Biochem 1996;29:139-44. https://doi.org/10.1016/0009-9120(95)02043-8
  26. Kurihara H, Fukami H, Asami S, Toyoda Y, Nakai M, Shibata H, Yao XS. Effects of oolong tea on plasma antioxidative capacity in mice loaded with restraint stress assessed using the oxygen radical absorbance capacity (ORAC) assay. Biol Pharm Bull 2004;27:1093-8. https://doi.org/10.1248/bpb.27.1093
  27. Han JH, Lee HJ, Kim TS, Kang MH. The effect of glutathione S-transferase (GST) M1 and T1 polymorphisms on blood pressure, blood glucose, and lipid profiles following the supplementation of kale (Brassica oleracea acephala) juice in South Korean subclinical hypertensive patients. Nutr Res Pract 2015;9:49-56. https://doi.org/10.4162/nrp.2015.9.1.49
  28. Tominaga Y, Nakagawa K, Mae T, Kitano M, Yokota S, Arai T, Ikematsu H, Inoue S. Licorice flavonoid oil reduces total body fat and visceral fat in overweight subjects: a randomized, double-blind, placebocontrolled study. Obes Res Clin Pract 2009;3:I-IV. https://doi.org/10.1016/S1871-403X(09)00064-7
  29. Aoki F, Honda S, Kishida H, Kitano M, Arai N, Tanaka H, Yokota S, Nakagawa K, Asakura T, Nakai Y, Mae T. Suppression by licorice flavonoids of abdominal fat accumulation and body weight gain in high-fat diet-induced obese C57BL/6J mice. Biosci Biotechnol Biochem 2007;71:206-14.
  30. Kamisoyama H, Honda K, Tominaga Y, Yokota S, Hasegawa S. Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats. Biosci Biotechnol Biochem 2008;72:3225-31.
  31. Lee BK, Lee SJ, Joo JS, Cho KS, Kim NS, Kim HJ. Association of Glutathione S-transferase genes (GSTM1 and GSTT1) polymorphisms with hypertension in lead-exposed workers. Mol Cell Toxicol 2012;8:203-8. https://doi.org/10.1007/s13273-012-0025-5
  32. Hussain K, Salah N, Hussain S, Hussain S. Investigate the role of glutathione s transferase (GST) polymorphism in development of hypertension in UAE population. Iran Red Crescent Med J 2012;14:479-82.
  33. Polidori MC, Carrillo JC, Verde PE, Sies H, Siegrist J, Stahl W. Plasma micronutrient status is improved after a 3-month dietary intervention with 5 daily portions of fruits and vegetables: implications for optimal antioxidant levels. Nutr J 2009;8:10. https://doi.org/10.1186/1475-2891-8-10
  34. Tyssandier V, Feillet-Coudray C, Caris-Veyrat C, Guilland JC, Coudray C, Bureau S, Reich M, Amiot-Carlin MJ, Bouteloup-Demange C, Boirie Y, Borel P. Effect of tomato product consumption on the plasma status of antioxidant microconstituents and on the plasma total antioxidant capacity in healthy subjects. J Am Coll Nutr 2004;23:148-56. https://doi.org/10.1080/07315724.2004.10719355
  35. Simic DV, Mimic-Oka J, Pljesa-Ercegovac M, Savic-Radojevic A, Opacic M, Matic D, Ivanovic B, Simic T. Byproducts of oxidative protein damage and antioxidant enzyme activities in plasma of patients with different degrees of essential hypertension. J Hum Hypertens 2006;20:149-55. https://doi.org/10.1038/sj.jhh.1001945
  36. Nielsen SE, Young JF, Daneshvar B, Lauridsen ST, Knuthsen P, Sandstrom B, Dragsted LO. Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects. Br J Nutr 1999;81:447-55. https://doi.org/10.1017/S000711459900080X
  37. Hofmann T, Kuhnert A, Schubert A, Gill C, Rowland IR, Pool-Zobel BL, Glei M. Modulation of detoxification enzymes by watercress: in vitro and in vivo investigations in human peripheral blood cells. Eur J Nutr 2009;48:483-91. https://doi.org/10.1007/s00394-009-0039-5
  38. Kang MH, Yun JS. The effects of exercise and other relating factors on the activity of erythrocyte antioxidant enzymes and plasma TRAP levles in male college students. Korean J Nutr 2002;35:30-6.
  39. Duthie SJ, Jenkinson AM, Crozier A, Mullen W, Pirie L, Kyle J, Yap LS, Christen P, Duthie GG. The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers. Eur J Nutr 2006;45:113-22. https://doi.org/10.1007/s00394-005-0572-9
  40. Nadeem N, Woodside JV, Kelly S, Allister R, Young IS, McEneny J. The two faces of ${\alpha}$- and ${\gamma}$-tocopherols: an in vitro and ex vivo investigation into VLDL, LDL and HDL oxidation. J Nutr Biochem 2012;23:845-51. https://doi.org/10.1016/j.jnutbio.2011.04.009
  41. Lopez-Uriarte P, Nogues R, Saez G, Bullo M, Romeu M, Masana L, Tormos C, Casas-Agustench P, Salas-Salvado J. Effect of nut consumption on oxidative stress and the endothelial function in metabolic syndrome. Clin Nutr 2010;29:373-80. https://doi.org/10.1016/j.clnu.2009.12.008
  42. Yuan L, Zhang L, Ma W, Zhou X, Ji J, Li N, Xiao R. Glutathione S-transferase M1 and T1 gene polymorphisms with consumption of high fruit-juice and vegetable diet affect antioxidant capacity in healthy adults. Nutrition 2013;29:965-71. https://doi.org/10.1016/j.nut.2012.12.025
  43. Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 1998;97:2222-9. https://doi.org/10.1161/01.CIR.97.22.2222
  44. Kim JS, Kim HY, Park YK, Kim TS, Kang MH. The effects of green vegetable juice (Angelica keiskei) supplementation on plasma lipids and antioxidant status in smokers. Korean J Nutr 2003;36:933-41.

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