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An Evaluation of Active Case Detection in Malaria Control Program in Kiyuni Parish of Kyankwanzi District, Uganda

  • Bahk, Young Yil (Department of Biotechnology, College of Biomedical and Health Science, Konkuk University) ;
  • Cho, Pyo Yun (Protist Resources Research Division, Nakdonggang National Institute of Biological Resources Sciences) ;
  • Ahn, Seong Kyu (Department of Parasitology and Tropical Medicine, School of Medicine, Inha University) ;
  • Lee, Woo-Joo (Department of Statistics, College of Natural Sciences, Inha University) ;
  • Kim, Tong-Soo (Department of Parasitology and Tropical Medicine, School of Medicine, Inha University) ;
  • Working Groups in ChildFund Korea (ChildFund Korea) ;
  • Uganda, Uganda (ChildFund Uganda)
  • 투고 : 2018.09.14
  • 심사 : 2018.11.02
  • 발행 : 2018.12.31

초록

Malaria remains one of the leading health burdens in the developing world, especially in several sub-Saharan Africa countries; and Uganda has some of the highest recorded measures of malaria transmission intensity in the world. It is evident that the prevalence of malaria infection, the incidence of disease, and mortality from severe malaria remain very high in Uganda. Although the recent stable political and economic situation in the last few decades in Uganda supported for a fairly good appreciation of malaria control, the declines in infection, morbidity, and mortality are not sufficient to interrupt transmission and this country is among the top 4 countries with cases of malaria, especially among children under 5 years of age. In fact, Uganda, which is endemic in over 95% of the country, is a representative of challenges facing malaria control in Africa. In this study, we evaluated an active case detection program in 6 randomly selected villages, Uganda. This program covered a potential target population of 5,017 individuals. Our team screened 12,257 samples of malaria by active case detection, every 4 months, from February 2015 to January 2017 in the 6 villages (a total of 6 times). This study assessed the perceptions and practices on malaria control in Kiyuni Parish of Kyankwanzi district, Uganda. Our study presents that the incidence of malaria is sustained high despite efforts to scale-up and improve the use of LLINs and access to ACDs, based on the average incidence confirmed by RDTs.

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참고문헌

  1. Roll Back Malaria. The Global Malaria Action Plan: For a Malaria-Free World. Geneva, Switzerland. World Health Organization. 2008.
  2. Arrow KJ, Panosian CB, Gelband H. Saving Lives, Buying Time: Economics of malaria drugs in an age of resistance. Washinton DC, USA. National Academic Press. 2004.
  3. World Health Organization. World Malaria Report 2016. Geneva, Switzerland. World Health Organization. 2016.
  4. Mendis K, Rietveld A, Warsame M, Bosman A, Greenwood B, Wernsdorfer WH. From malaria control to eradication: the WHO perspective. Trop Med Int Health 2009; 14: 802-809. https://doi.org/10.1111/j.1365-3156.2009.02287.x
  5. World Health Organization. Uganda neonatal and child health profile. [Internet]; 2015. Available from: http://who.int/maternal_child_adolescent/epidemiology/profiles/neonatal_child/uga.pdf. Accessed on 20 Feb. 2017.
  6. Breman JG, Alilio MS, Mills A. Conquering the intolerable burden of malaria: what’s new, what’s needed: a summary. Am J Trop Med Hyg 2004; 71 (suppl): 1-15.
  7. Mutero CM, Kramer RA, Paul C, Lesser A, Miranda ML, Mboera LEG, Kiptui R, Kabatereine N, Ameneshewa B. Factors influencing malaria control policy-making in Kenya, Uganda and Tanzania. Malaria J 2014; 13: 305. https://doi.org/10.1186/1475-2875-13-305
  8. Greenwood BM. Control to elimination: implications for malaria research. Trends in Parasitol 2008; 24: 449-454. https://doi.org/10.1016/j.pt.2008.07.002
  9. Kassam R, Collins JB, Liow E, Rasool N. Narrative review of current context of malaria and management strategies in Uganda (Part I). Acta Tropica 2015; 152: 252-268. https://doi.org/10.1016/j.actatropica.2015.07.028
  10. Roll Back Malaria. Global Strategic Plan. Roll Back Malaria. 2005-2015. Geneva, Switzerland. World Health Organization. 2005.
  11. Lengeler C. Insecticide-treated nets for malaria control: real gains. Bull World Health Organ 2004; 82: 84.
  12. Malaria Control Programme Ministry of Health. Uganda malaria control strategic plan: 2005/06-2009/10. [Internet]; Available from: http://www.healthyfutures.eu/images/healthy/deliverables/D5.1/Uganda/uganda%20national%20malaria%20control%20strategy%202005%20-%202010.pdf. Accessed on 20 Feb. 2017.
  13. President's Malaria Initiative. Uganda Malaria Operational Plan FY 2016. [Internet]; Available from: https://www.pmi.gov/docs/default-source/default-document-library/malaria-operational-plans/fy16/fy-2016-uganda-malaria-operational-plan.pdf?sfvrsn=5.
  14. Musoke D, Miiro G, Karani G, Morris K, Kasasa S, Ndejjo R, Musoke MB. Promising perceptions, divergent practices and barriers to integrated malaria prevention in Wakiso district, Uganda: a mixed methods study. PLoS One 2015; 10: e0122699. https://doi.org/10.1371/journal.pone.0122699
  15. Fegan GW, Noor AM, Akhwale WS, Cousens S, Snow RW. Effect of expanded insecticide-treated bednet coverasge on child survival in rural Kenya: a longitudinal study. Lancet 2007; 370: 1035-1039. https://doi.org/10.1016/S0140-6736(07)61477-9
  16. Ng’ang’a PN, Shililu J, Jayasinghe G, Kimani V, Kabutha C, Kabuge L, Kabiru E, Githure J, Mutero C. Malaria vector control practices in an irrigated rice agro-ecosystem in central Kenya and implications for malaria control. Malaria J 2008; 7: 146. https://doi.org/10.1186/1475-2875-7-146
  17. Awor P, Wamani H, Bwire G, Jagoe G, Peterson S. Private sector drug shops in integrated community case management of malaria, pneumonia, and diarrhea in children in Uganda. Am J Trop Med Hyg 2012; 87: 92-96. https://doi.org/10.4269/ajtmh.2012.11-0791
  18. ACTwatch Group, Kaula H, Buyungo P, Opigo J. Private sector role, readiness and performance for malaria case management in Uganda, 2015. Malaria J 2017; 16: 219. https://doi.org/10.1186/s12936-017-1824-x
  19. Cohen J, Dupas P, Schaner S. Price subsidies, diagnostic tests, and targeting of malaria treatment: evidence from a randomized controlled trial. Am Econ Rev 105: 609-645.
  20. Hutchinson E, Hutchison C, Lal S, Hansen K, Kayendeke M, Nabirye C, Magnussen P, Clarke SE, Mbonye A, Chandler CIR. Introducing rapid tests for malaria into the retail sector: what are the unintended consequences? BMJ Glob Health 2017; 2: e000067. https://doi.org/10.1136/bmjgh-2016-000067
  21. Kleinman A. Four social theories for global health. Lancet 2010; 375: 1518-1519. https://doi.org/10.1016/S0140-6736(10)60646-0
  22. Moorthy VS, Reed Z, Smith PG. MALVAC 2008: Measures of efficacy of malaria vaccines in phase 2b and phase 3 trials-scientific, regulatory and public health perspectives. Vaccine 2009; 27: 624-628. https://doi.org/10.1016/j.vaccine.2008.11.034
  23. Tiono AB, Kangoye DT, Rehman AM, Kargougou DG, Kabore Y, Diarra A, Ouedraogo E, Nebie I, Ouedraogo A, Okech B, Milligan P, Sirima SB. Malaria incidence in children in South-West Burkina Faso: comparison of active and passive case detection methods. PLoS One 2014; 9: e86936. https://doi.org/10.1371/journal.pone.0086936
  24. Taremwa IM, Ashaba S, Adrama HO, Ayebazibwe C, Omoding D, Kemeza I, Yatuha J, Turuho T, MacDonald NE, Hilliard R. Knowledge, attitude and behavior towards the use of insecticide treated mosquito nets among pregnant women and children in rural Southwestern Uganda. BMC Public Health 2017; 17: 794. https://doi.org/10.1186/s12889-017-4824-4
  25. Okello PE, Okello PE, Van Bortel W, Byaruhanga AM, Correwyn A, Roelants P, Talisuna A, D’Alessandro U, Coosemans M. Variation in malaria transmission intensity in seven sites throughout Uganda. Am J Trop Med Hyg 2006; 75: 219-225. https://doi.org/10.4269/ajtmh.2006.75.219
  26. Wielgosz B, Mangheni M, Tsegai D, Ringler C. Malaria and agriculture: a review of the literature with a focus on the potential of integrated pest and vector management for Uganda. Washinton DC, USA. International Food Policy Research Institute. 2012, IFPRI Discussion Paper 01232.
  27. Chong CK, Cho PY, Na BK, Ahn SK, Kim JS, Lee JS, Lee SK, Han ET, Kim HY, Park YK, Cha SH, Kim TS. Evaluation of the accuracy of the EasyTestTM Malaria Pf/Pan Ag, a rapid diagnostic test, in Uganda. Korean J Parasitol 2014; 52: 501-505. https://doi.org/10.3347/kjp.2014.52.5.501
  28. ACTwatch. ACTwatch Baseline and Endline Household Survey Results 2009-2012: Benin, Democratic Republic of Congo, Madagascar, Nigeria, Uganda, Zambia. [Internet]; 2013. Available from: http://www.actwatch.info/sites/default/files/content/publications/attachments/ACTwatch%2520HH%2520Report%2520and%2520Endline.pdf. Accessed on 12 Jan 2014.
  29. Bastiaens GJH, Bousema T, Leslie T. Scale-up of malaria rapid diagnostic tests and artemisinin-based combination therapy: Challenges and perspectives in sub-Saharan Aftrica. PLoS Med 2014; 11: 1-4.
  30. Winstanley, P, Ward S, Snow R, Breckenridge A. Therapy of falciparum malaria in sub-Saharan Africa: from molecule to policy. Clin Microbiol Rev 2004; 17: 612-637. https://doi.org/10.1128/CMR.17.3.612-637.2004
  31. Yeka A, Gasasira A, Mpimbaza A, Achan J, Nankabirwa J, Nsobya S, Staedke SG, Donnelly MJ, Wabwire-Mangen F, Talisuna A, Dorsey G, Kamya MR, Rosenthal PJ. Malaria in Uganda: Challenges to control on the long road to elimination I. Epidemiology and current control efforts. Acta Tropica 2012; 121: 184-195. https://doi.org/10.1016/j.actatropica.2011.03.004
  32. Tatem AJ, Smith DL, Gething PW, Kabaria CW, Snow RW, Hay SI. Ranking of elimination feasibility between malaria-endemic countries. Lancet 2010; 376: 1579-1591. https://doi.org/10.1016/S0140-6736(10)61301-3
  33. Magisha F, Arinaitwe J. Sleeping arrangements and mosquito net use among under-fives. Results from the Uganda Demographic and Health Survey. Malar J 2003; 2: 40. https://doi.org/10.1186/1475-2875-2-40
  34. Gimnig JE, Vulule JM, Lo TQ, Kamau L, Kolczak MS, Phillips-Howard PA, Methenge EM, ter Kuile FO, Nahlen BL, Hightower AW, Hawley WA. Impact of permethrin-treated bed nets on entomologic indices in an area of intense year-round malaria transmission. Am J Trop Med Hyg 2003; 68: 16-22. https://doi.org/10.4269/ajtmh.2003.68.16
  35. Uganda Bureau of Statistics, ICF Macro. Uganda Malaria Indicator Survey 2009. [Internet]; 2010. Available from: https://dhsprogram.com/pubs/pdf/MIS6/MIS6.pdf.

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