Parasites, Hosts and Diseases

  • 제56권6호
  • /
  • Pages.577-581
  • /
  • 2018
  • /
  • 2982-5164(pISSN)
  • /
  • 1738-0006(eISSN)
대한기생충학·열대의학회 (The Korea Society for Parasitology and Tropical Medicine)
권호 표지
DOI QR코드

DOI QR Code

Impact of Single Dose Praziquantel Treatment on Schistosoma haematobium Infection among School Children in an Endemic Nigerian Community

  • Adewale, Babatunde (Public Health and Epidemiology Department, Nigerian Institute of Medical Research) ;
  • Mafe, Margaret A. (Public Health and Epidemiology Department, Nigerian Institute of Medical Research) ;
  • Sulyman, Medinat A. (Public Health and Epidemiology Department, Nigerian Institute of Medical Research) ;
  • Idowu, Emmanuel T. (Zoology Department, Faculty of Science, University of Lagos) ;
  • Ajayi, Morakinyo B. (Public Health and Epidemiology Department, Nigerian Institute of Medical Research) ;
  • Akande, David O. (Public Health and Epidemiology Department, Nigerian Institute of Medical Research) ;
  • Mckerrow, James H. (Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego) ;
  • Balogun, Emmanuel O. (Department of Biochemistry, Ahmadu Bello University)
  • 투고 : 2018.05.25
  • 심사 : 2018.11.12
  • 발행 : 2018.12.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Schistosomiasis is prevalent in Nigeria, and the foremost pathogen is Schistosoma haematobium, which affects about 29 million people. Single dose of the drug praziquantel is often recommended for treatment but the efficacy has not been documented in certain regions. Therefore, this study was designed to assess the impact of single dose praziquantel treatment on S. haematobium infection among school children in an endemic community of South-Western Nigeria. Urine samples were collected from 434 school children and 10 ml was filtered through Nucleopore filter paper before examination for egg outputs by microscopy. The prevalence was 24.9% at pre-treatment. There was no statistically significant difference for the prevalence of infection between males (14.7%) and females (10.2%), although the mean egg count for the females (9.87) was significantly more (P<0.05) than the males (6.06). At 6 and 12 months post-treatment there was 74.4% and 86.4% reduction in the mean egg count, respectively. Interestingly, an increased prevalence of infection from 2.1% at 6 months to 7.7% at 12 months post-treatment was observed, nonetheless the mean egg count was reduced to 0.27 at 12th month from 1.98 at 6 months post-treatment. Resurgence in the prevalence rate between 6 and 12 months post-treatment with praziquantel is herein reported and the need for a follow-up treatment in endemic areas for adequate impact on schistosomiasis control is discussed.

키워드

참고문헌

  1. Cowper SG. Schistosomiasis in Nigeria. Ann Trop Med Parasitol 1963; 57: 307-322. https://doi.org/10.1080/00034983.1963.11686184
  2. Colley DG, Bustinduy AL, Secor E, King CH. Human schistosomiasis Lancet 2014; 383: 2253-2264. https://doi.org/10.1016/S0140-6736(13)61949-2
  3. Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J. Schistosomiasis and water resources development: systematic review, metaanalysis, and estimates of people at risk. Lancet Infect Dis 2006; 6: 411-425. https://doi.org/10.1016/S1473-3099(06)70521-7
  4. TchuemTchuente L, Rollinson D, Stothard RJ, Molyneux D. Moving from control to elimination of schistosomiasis in sub-Saharan Africa: time to change and adapt strategies. Infect Dis Poverty 2017; 6: 42. https://doi.org/10.1186/s40249-017-0256-8
  5. Molyneux DH, Savioli L, Engels D. Neglected tropical diseases: progress towards addressing the chronic pandemic. Lancet 2017; 389: 312-325. https://doi.org/10.1016/S0140-6736(16)30171-4
  6. King CH, Dangerfield-Cha M. The unacknowledged impact of chronic schistosomiasis. Chronic Illn 2008; 4: 65-79. https://doi.org/10.1177/1742395307084407
  7. Kjetland EF, Ndhlovu PD, Gomo E, Mduluza T, Midzi N, Gwanzura L, Mason PR, Sandvik L, Friis H, Gundersen SG. Association between genital schistosomiasis and HIV in rural Zimbabwean women. AIDS 2006; 20: 593-600. https://doi.org/10.1097/01.aids.0000210614.45212.0a
  8. Bustinduy A, King C, Scott J, Appleton S, Sousa-Figueiredo JC, Betson M, Stothard JR. HIV and schistosomiasis co-infection in African children. Lancet Infect Dis 2014; 14: 640-649. https://doi.org/10.1016/S1473-3099(14)70001-5
  9. Odaibo AB, Adewunmi CO, Olorunmola FO, Adewoyin FB, Olofintoye LK, Adewunmi TA, Adetula MO, Awe CO, Akinyemi F. Preliminary studies on the prevalence and distribution of urinary schistosomiasis in Ondo State, Nigeria. Afr J Med Med Sci 2004; 33: 219-224.
  10. Hotez PJ, Asojo OA, Adesina AM. Nigeria: "Ground Zero" for the high prevalence neglected tropical diseases. PLoS Negl Trop Dis 2012; 6: e1600. https://doi.org/10.1371/journal.pntd.0001600
  11. van der Werf MJ, Bosompem KM, de Vlas SJ. Schistosomiasis control in Ghana: case management and means for diagnosis and treatment within the health system. Trans R Soc Trop Med Hyg 2003; 97: 146-152. https://doi.org/10.1016/S0035-9203(03)90102-7
  12. Savioli L, Stansfield S, Bundy DA, Mitchell A, Bhatia R, Engels D, Montresor A, Neira M, Shein AM. Schistosomiasis and soiltransmitted helminth infections: forging control efforts. Trans R Soc Trop Med Hyg 2002; 96: 577-579. https://doi.org/10.1016/S0035-9203(02)90316-0
  13. Unicef. Water and sanitation monitoring platform Nigeria. Water and sanitation summary sheet. [Internet]; 2008. Available from: https://www.unicef.org/nigeria/NG_resources_washsummary.pdf.
  14. Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Sachs SE, Sachs JD, Savioli L. Control of neglected tropical diseases. N Engl J Med 2007; 357: 1018-1027. https://doi.org/10.1056/NEJMra064142
  15. Hotez PJ, Fenwick A, Savioli L, Molyneux DH. Rescuing the bottom billion through control of neglected tropical diseases. Lancet 2009; 373: 1570-1575. https://doi.org/10.1016/S0140-6736(09)60233-6
  16. Toure S, Zhang Y, Bosque-Oliva E, Ky C, Ouedraogo A, Koukounari A, Gabrielli AF, Bertrand S, Webster JP, Fenwick A. Two-year impact of Single praziquantel treatment on infection in the National control programme on schistosomiasis in Burkina Faso. Bull World Health Organ 2008; 86: 780-787. https://doi.org/10.2471/BLT.07.048694
  17. Hotez PJ. Mass drug administration and integrated control for the world’s high prevalence neglected tropical diseases. Clin Pharmacol Ther 2009; 85: 659-664. https://doi.org/10.1038/clpt.2009.16
  18. Rollinson D, Knopp S, Levitz S, Stothard JR, Tchuem Tchuente LA, Garba A, Mohammed KA, Schur N, Person B, Colley DG, Utzinger J. Time to set the agenda for schistosomiasis elimination. Acta Trop 2013; 128: 423-440. https://doi.org/10.1016/j.actatropica.2012.04.013
  19. Hotez PJ, Fenwick A. Schistosomiasis in Africa: An emerging tragedy in our new global health decade. PLoS Negl Trop Dis 2009; 3: e485. https://doi.org/10.1371/journal.pntd.0000485
  20. Mafe MA, von Stamm T, Utzinger J, N’Goran EK. Control of urinary schistosomiasis: an investigation into the effective use of questionnaires to identify high-risk communities and individuals in Niger State, Nigeria. Trop Med Int Health 2000; 5: 53-63. https://doi.org/10.1046/j.1365-3156.2000.00508.x
  21. Tian-Bi YT, Ouattara M, Knopp S, Coulibaly JT, Hurlimann E, Webster B, Allan F, Rollinson D, Meite A, Diakite NR, Konan CK, N'Goran EK, Utzinger J. Interrupting seasonal transmission of Schistosoma haematobium and control of soil-transmitted helminthiasis in northern and central Cote d'Ivoire: a SCORE study protocol. BMC Public Health 2018; 18: 186. https://doi.org/10.1186/s12889-018-5044-2
  22. Sabah AA, Fletcher C, Webbe G, Doenhoff MJ. Schistosoma mansoni: chemotherapy of infections of different ages. Exp Parasitol 1986; 61: 294-303. https://doi.org/10.1016/0014-4894(86)90184-0
  23. World Health Organization. World Health Assembly Resolution (WHA) 66.12 Neglected tropical diseases. Geneva, Switzerland. World Health Organization. 2013.
  24. World Health Organization. Prevention and Control of Schistosomiasis and Soil-Transmitted Helminthiasis. Report of a WHO Expert Committee. Geneva, Switzerland. World Health Organization. pp 1-57.
  25. Nsowah-Nuamah NN, Aryeetey ME, Jolayemi ET, Wagatsuma Y, Mensah G, Dontwi IK, Nkrumah FK, Kojima S. Predicting the timing of second praziquantel treatment and its effect on reduction of egg counts in southern Ghana. Acta Trop 2004; 90: 263-270. https://doi.org/10.1016/j.actatropica.2002.03.001
  26. World Health Organization. Preventive Chemotherapy in Human Helminthiasis: Coordinated Use of Anthelminthic Drugs in Control Interventions: A Manual for Health Professionals and Programme Managers. Geneva, Switzerland. World Health Organization. 2006.

피인용 문헌

  1. Differential impact of mass and targeted praziquantel delivery on schistosomiasis control in school-aged children: A systematic review and meta-analysis vol.13, pp.10, 2019, https://doi.org/10.1371/journal.pntd.0007808
  2. Epidemiological dynamics and associated risk factors of S. haematobium in humans and its snail vectors in Nigeria: a meta-analysis (1983-2018) vol.114, pp.2, 2020, https://doi.org/10.1080/20477724.2020.1728164