Journal of Integrative Natural Science (통합자연과학논문집)

The Basic Science Institute Chosun University (조선대학교 기초과학연구원)
권호 표지
DOI QR코드

DOI QR Code

Protein-Protein Interaction Analysis of KiSS1-Derived Peptide Receptor with Kisspeptin-10 and Kisspeptin-15

  • Received : 2018.01.22
  • Accepted : 2018.03.25
  • Published : 2018.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

KiSS1-derived peptide receptor, a GPCR protein, binds with the hormone Kisspeptin plays a major role in the neuroendocrine regulation of reproduction. It is important in the onset of puberty and triggers the release of gonadotrophin-releasing hormone. It is a potential drug target for the disorders related to GnRH, hence, analysing the structural features of the receptor becomes important. The three dimensional of the receptor modelled in a previous study was utilised. In this study, we have analysed the protein - protein interaction of the receptor with Kisspeptin 10 and 15. The study revealed the important residues which are involved in the interaction. The result of this study could be helpful in understanding the mechanism of Kiss1 receptor activation and the pathophysiology of the disorders related to the receptor.

Keywords

References

  1. A. I. Muir, L. Chamberlain, N. A. Elshourbagy, D. Michalovich, D. J. Moore, A. Calamari, P. G. Szekeres, H. M. Sarau, J. K. Chambers, P. Murdock, K. Steplewski, U. Shabon, J. E. Miller, S. E. Middleton, J. G. Darker, C. G. Larminie, S. Wilson, D. J> Bergsma, P. Emson, R. Faull, K. L. Philpott, and D. C. Harrison, "AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1", J. Biol. Chem., Vol. 276, pp. 28969-28975, 2001. https://doi.org/10.1074/jbc.M102743200
  2. T. Ohtaki, Y. Shintani, S. Honda, H. Matsumoto, A. Hori, K. Kanehashi, Y. Terao, S. Kumano, Y. Takatsu, Y. Masuda, Y. Ishibashi, T. Watanabe, M. Asada, T. Yamada, M. Suenaga, C. Kitada, S. Usuki, T. Kurokawa, H. Onda, O. Nishimura, and M. Fujino, "Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor", Nature, Vol. 411, pp. 613-617, 2001. https://doi.org/10.1038/35079135
  3. M. Kotani, M. Detheux, A. Vandenbogaerde, D. Communi, J. M. Vanderwinden, E. Le Poul, S. Brezillon, R. Tyldesley, N. Suarez-Huerta, F. Vandeput, C. Blanpain, S. N. Schiffmann, G. Vassart, and M. Parmentier, "The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54", J. Biol. Chem., Vol. 276, pp. 34631-34636, 2001. https://doi.org/10.1074/jbc.M104847200
  4. J.-H. Lee, M. E. Miele, D. J. Hicks, K. K. Phillips, J. M. Trent, B. E. Weissman, and D. R. Welch, "KiSS-1, a novel human malignant melanoma metastasis-suppressor gene", J. Natl. Cancer Inst., Vol. 88, pp. 1731-1737, 1996. https://doi.org/10.1093/jnci/88.23.1731
  5. S. M. Popa, D. K. Clifton, and R. A. Steiner, "The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproduction", Annu. Rev. Physiol., Vol. 70, pp. 213-238, 2008. https://doi.org/10.1146/annurev.physiol.70.113006.100540
  6. T. M. Plant, S. Ramaswamy, and M. J. Dipietro, "Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing hormone discharges", Endocrinology, Vol. 147, pp. 1007-1013, 2006. https://doi.org/10.1210/en.2005-1261
  7. M. Shahab, C. Mastronardi, S. B. Seminara, W. F. Crowley, S. R. Ojeda, and T. M. Plant, "Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates", Proc. Natl. Acad. Sci. U. S. A., Vol. 102, pp. 2129-2134, 2005. https://doi.org/10.1073/pnas.0409822102
  8. S. B. Seminara, S. Messager, E. E. Chatzidaki, R. R. Thresher, J. S. Acierno, J. K. Shagoury, Y. Bo-Abbas, W. Kuohung, K. M. Schwinof, A. G. Hendrick, D. Zahn, J. Dixon, U. B. Kaiser, S. A. Slaugenhaupt, J. F. Gusella, S. O'Rahilly, M. B. Carlton, W. F. Crowley, S. A. Aparicio, and W. H. Colledge, "The GPR54 gene as a regulator of puberty". N. Engl. J. Med., Vol. 349, pp. 1614-1627. 2003. https://doi.org/10.1056/NEJMoa035322
  9. S. Funes, J. A. Hedrick, G. Vassileva, L. Markowitz, S. Abbondanzo, A. Golovko, S. Yang, F. J. Monsma, and E. L. Gustafson, "The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system", Biochem. Biophys. Res. Commun., Vol. 312, pp. 1357-1363, 2003. https://doi.org/10.1016/j.bbrc.2003.11.066
  10. Y. Horikoshi, H. Matsumoto, Y. Takatsu, T. Ohtaki, C. Kitada, S. Usuki, and M. Fujino, "Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans", J. Clin. Endocrinol. Metab., Vol. 88, pp. 914-919, 2003. https://doi.org/10.1210/jc.2002-021235
  11. E. J. Mead, J. J. Maguire, R. E. Kuc, and A. P. Davenport, "Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels", Endocrinology, Vol. 148, pp. 140-147, 2007. https://doi.org/10.1210/en.2006-0818
  12. A. C. Arai, Y.-F. Xia, E. Suzuki, M. Kessler, O. Civelli, and H.-P. Nothacker, "Cancer metastasis-suppressing peptide metastin upregulates excitatory synaptic transmission in hippocampal dentate granule cells", J. Neurophysiol., Vol. 94, pp. 3648-3652, 2005. https://doi.org/10.1152/jn.00590.2005
  13. A. C. Hauge-Evans, C. C. Richardson, H. M. Milne, M. R. Christie, S. J. Persaud, and P. M. Jones, "A role for kisspeptin in islet function", Diabetologia, Vol. 49, pp. 2131-2135, 2006. https://doi.org/10.1007/s00125-006-0343-z
  14. S. Nagarajan and T. Madhavan, "Structure prediction of kiss1-derived peptide receptor using comparative modelling", J. Chosun Natural Sci., Vol. 9, pp. 136-143, 2016. https://doi.org/10.13160/ricns.2016.9.2.136
  15. A. Lamiable, P. Thevenet, J. Rey, M. Vavrusa, P. Derreumaux, and P. Tuffery, "PEP-FOLD3: faster de novo structure prediction for linear peptides in solution and in complex", Nucleic Acids Res., Vol. 44, pp. W449-W454, 2016. https://doi.org/10.1093/nar/gkw329
  16. S. R. Comeau, D. W. Gatchell, S. Vajda, and C. J. Camacho, "ClusPro: an automated docking and discrimination method for the prediction of protein complexes", Bioinformatics, Vol. 20, pp. 45-50, 2004. https://doi.org/10.1093/bioinformatics/btg371
  17. S. R. Comeau, D. W. Gatchell, S. Vajda, and C. J. Camacho, "ClusPro: a fully automated algorithm for protein-protein docking", Nucleic Acids Res., Vol. 32, pp. 96-99, 2004.
  18. D. Kozakov, D. Beglov, T. Bohnuud, S. Mottarella, B. Xia, D. Hall, and S. Vajda, "How good is automated protein docking?", Proteins, Vol. 81, pp. 2159-2166, 2013. https://doi.org/10.1002/prot.24403
  19. M. F. Lensink and S. J. Wodak, "Docking, scoring, and affinity prediction in CAPRI", Proteins, Vol. 81, pp. 2082-2095, 2013. https://doi.org/10.1002/prot.24428
  20. D. Kozakov, R. Brenke, S. R. Comeau, and S. Vajda S "PIPER: An FFT-based protein docking program with pairwise potentials", Proteins, Vol. 65, pp. 392-406, 2006. https://doi.org/10.1002/prot.21117

Cited by

  1. Protein-Protein Interaction Analysis of Corticotropin - Releasing Hormone Receptor 1 with Corticotropin-Releasing Hormone and Sauvagine vol.11, pp.2, 2018, https://doi.org/10.13160/ricns.2018.11.2.101