동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제29권1호
  • /
  • Pages.57-68
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  • 2018
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  • 1226-6396(pISSN)
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  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
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감맥대조탕 복합추출물의 만성스트레스 유발 생쥐의 항우울 작용에 관한 실험연구

Experimental Study on the Anti-Depressant Effects of Gammakdaejo-tang Complex Extracts in Rats Induced with Chronic Mild Stress

  • 이유찬 (동의대학교 한의과대학원 한방신경정신과학교실) ;
  • 김보경 (동의대학교 한의과대학원 한방신경정신과학교실)
  • Lee, Yu-Chan (Department of Oriental Neuropsychiatry, Graduate School of Oriental Medicine in Dong-eui University) ;
  • Kim, Bo-Kyung (Department of Oriental Neuropsychiatry, Graduate School of Oriental Medicine in Dong-eui University)
  • 투고 : 2018.03.14
  • 심사 : 2018.03.21
  • 발행 : 2018.03.30
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초록

Objectives: To experimentally assess the anti-depressant effects of Gammakdaejo-tang Complex Extracts (GMDJ-Tang) in rats. Methods: Twenty Wistar Hannover (160~170 g) stressed rats were treated with different concentrations of GMDJ-Tang extracts i.e., 0, 62.5 mg/kg, 125 mg/kg, and 250 mg/kg. Chronic mild stress was induced by food deprivation, empty bottles, forced swimming, flickered light, tilt cages, shaking cages, high density breeding, water deprivation, and by soaking the litter cover according to fixed schedule. Blood and brain tissue samples were collected for biochemical analysis. Tests included serotonin and ELISA assays. Results: GMDJ-tang increased the weight of treated rats as well as levels of serotonin, BDNF and TrkB; however, the differences were not significant. In contrast, the extracts significantly decreased blood glucose in stressed rats. GMDJ-tang extracts did not significantly impact Serum AST, ALT, leukocytes, erythrocytes and thrombocytes when comparing treatment groups to control rats. Likewise, hemoglobin, hematocrit and PLT increased in treatment groups following treatment with GMDJ-tang, but this change was without significance. Conclusions: These results suggest that GMDJ-tang can alleviate chronic mild stress in rats, possibly through anti-depressant activity.

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피인용 문헌

  1. 갱년기 우울증에 대한 중약 중재 임상연구 고찰 -CNKI에서 검색된 무작위배정 비교임상시험을 중심으로 vol.31, pp.1, 2018, https://doi.org/10.7231/jon.2020.31.1.049