The Effect of Nasal Steroid Spray on Contact Granuloma of Larynx

접촉성 육아종 치료에 비강 스테로이드 분무가 미치는 영향

  • Lee, GilJoon (Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University School of Medicine) ;
  • Ahn, Dongbin (Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University School of Medicine) ;
  • Sohn, Jin Ho (Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University School of Medicine)
  • 이길준 (경북대학교 의과대학 이비인후-두경부외과학교실) ;
  • 안동빈 (경북대학교 의과대학 이비인후-두경부외과학교실) ;
  • 손진호 (경북대학교 의과대학 이비인후-두경부외과학교실)
  • Received : 2018.01.09
  • Accepted : 2018.10.30
  • Published : 2018.12.30

Abstract

Background and Objectives : Laryngeal contact granuloma is benign inflammatory disease induced by excessive mechanical contact of larynx such as endotracheal intubation, voice abuse, laryngeal microsurgery as well as laryngopharygeal reflux. Because it is caused by various risk factors, multiple treatment modalities are required. The purpose of study is to evaluate treatment effect of topical steroid through nasal cavity in contact granuloma. Materials and Method : Fifty-two patients were enrolled in this study with exception of intubation granuloma. Patients were classified with four groups (Proton pump inhibitor (PPI), Nasal steroid spray (SPR), PPI+SPR, Observation) according to treatment modality. Results : Patients who treated with PPI (Odds ratio 2.45, p=0.03) and combination of PPI and SPR (Odds ratio 2.88, p<0.01) had significantly better response than patients who not treated with medical therapy. Conclusion : Combination therapy of nasal steroid spray and PPI is effective for contact granuloma of larynx and considered as a treatment of choice rather than PPI only treatment.

Keywords

References

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