Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Situs inversus totalis in a dog with splenic marginal zone lymphoma

  • Choi, Sooyoung (College of Veterinary Medicine, Kangwon National University) ;
  • Kim, Heesu (College of Veterinary Medicine, Kangwon National University) ;
  • Lee, Kija (College of Veterinary Medicine, Kyungpook National University) ;
  • Park, Inchul (College of Veterinary Medicine, Kangwon National University)
  • Received : 2018.09.17
  • Accepted : 2018.12.15
  • Published : 2018.12.30
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Abstract

An 11-year-old intact male mixed-breed dog was referred for evaluation of a splenic mass. On radiographs, the cardiac apex, stomach, and head of the spleen were on the right and the descending colon was on the left of the midline. In addition, the left kidney was located more cranially than the right kidney. Standard two-dimensional echocardiographic images were obtained from each inverted left and right parasternal windows. Furthermore, the spleen was observed on the right side and a splenic mass was found on the splenic tail. Based on the radiographic and ultrasonographic characteristics of the patient, a diagnosis of situs inversus totalis (SIT) and a splenic mass was made, and splenic resection was performed successfully with no unexpected complications. The splenic mass was confirmed histopathologically as being marginal zone lymphoma (MZL). This report describes a dog with SIT and splenic MZL.

Keywords

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Fig. 1. (A) Ventrodorsalthoracic view revealing dextrocardia and the presence of an oval mass with soft tissue opacity (arrow) on the left diaphragm, which was regarded to have developed as the result of the diaphragmatic repair. (B) Left lateral thoracic view revealing the caudal vena cava entering the left crus of the diaphragm.

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Fig. 3. (A) Echocardiogram obtained when all electrodes were placed in the mirrored locations. The left ventricular outflow track view was obtained from the left parasternal position. (B) Abdominal ultrasonography revealing the spleen on the right side and a solitary spleen mass with mixed echogenicity.

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Fig. 2. Ventrodorsal (VD) abdominal view showing that the fundus of the stomach and the head of the spleen were on the right side of the midline. The right kidney was located more caudally than the left kidney. (A) Radiographs taken at the time of the first visit, showing a left-sided descending colon (arrow). (B) VD radiography was repeated with a radiographic marker (barium sulfate) for confirmation of situs inversus totalis at the second visit for splenectomy. The descending colon (arrow) was observed on the right-sided abdomen.

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Fig. 4. Left: White pulp expanding in the spleen and compressing other splenic structures shown as a densely cellular, poorly demarcated, unencapsulated, expansileround cell neoplasm, composed of lymphoid nodules with an expanded and coalescing marginal zone layer compressing the fading mantle zone layer and germinal centers. Scale bar=500 μm. Right: Neoplastic cells with abundant pale cytoplasm and nuclei with peripheralization of the chromatin and one prominent nucleolus but without parachromatin clearing. Anisocytosis was mild. Mitotic values were low. Scale bar=50 μm.

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