Fig. 1. (A) Ventrodorsalthoracic view revealing dextrocardia and the presence of an oval mass with soft tissue opacity (arrow) on the left diaphragm, which was regarded to have developed as the result of the diaphragmatic repair. (B) Left lateral thoracic view revealing the caudal vena cava entering the left crus of the diaphragm.
Fig. 3. (A) Echocardiogram obtained when all electrodes were placed in the mirrored locations. The left ventricular outflow track view was obtained from the left parasternal position. (B) Abdominal ultrasonography revealing the spleen on the right side and a solitary spleen mass with mixed echogenicity.
Fig. 2. Ventrodorsal (VD) abdominal view showing that the fundus of the stomach and the head of the spleen were on the right side of the midline. The right kidney was located more caudally than the left kidney. (A) Radiographs taken at the time of the first visit, showing a left-sided descending colon (arrow). (B) VD radiography was repeated with a radiographic marker (barium sulfate) for confirmation of situs inversus totalis at the second visit for splenectomy. The descending colon (arrow) was observed on the right-sided abdomen.
Fig. 4. Left: White pulp expanding in the spleen and compressing other splenic structures shown as a densely cellular, poorly demarcated, unencapsulated, expansileround cell neoplasm, composed of lymphoid nodules with an expanded and coalescing marginal zone layer compressing the fading mantle zone layer and germinal centers. Scale bar=500 μm. Right: Neoplastic cells with abundant pale cytoplasm and nuclei with peripheralization of the chromatin and one prominent nucleolus but without parachromatin clearing. Anisocytosis was mild. Mitotic values were low. Scale bar=50 μm.
References
- Almeida G, Almeida M, Freitas L, Santos A, Mattos A. 2012. Dextrocardia and situs inversus in a dog. Veterinary World 5: 369-372. https://doi.org/10.5455/vetworld.2012.369-372
- Blegen H. 1949. Surgery in situs inversus. Ann Surg 129: 244-259. https://doi.org/10.1097/00000658-194902000-00009
- Buhl R, Koch J, Agerholm J, Maddox-Hyttel P, Eriksen L. 2004. Complete situs inversus in a two-year-old standaardbred horse. Vet Rec 154: 600-602. https://doi.org/10.1136/vr.154.19.600
- Carrig C, Suter P, Ewing G, Dungworth D. 1974. Primary dextrocardia with situs inversus, associated with sinusitis and bronchitis in a dog. J Am Vet Med Assoc 164: 1127-1134.
- Choi M, Hwang G, Yoo H, Yoon J, Heo J, Lee K, Chang D. 2001. Radiographic diagnosis-situs inversus of abdominal organs in a dog. Vet Radiol Ultrasound 42: 423-425. https://doi.org/10.1111/j.1740-8261.2001.tb00963.x
- Durant AM. 2008. What is your diagnosis? J Am Vet Med Assoc 232: 197-198. https://doi.org/10.2460/javma.232.2.197
- Edwards D, Kennedy J, Toal R, Maddux J, Barnhill M, Daniel G. 1989. Kartagener's syndrome in a chow chow dog with normal ciliary ultrastructure. Vet Pathol 26: 338-340. https://doi.org/10.1177/030098588902600409
- Edwards DF, Kennedy JR, Patton CS, Toal RL, Daniel GB, Lothrop CD. 1989. Familial immotile-cilia syndrome in English springer spaniel dogs. Am J Med Genet A 33: 290-298. https://doi.org/10.1002/ajmg.1320330303
- Evans H. 1987. Cyclopia, situs inversus and widely patent ductus arteriosus in a new-born pig, Sus scrofa. Anat Histol Embryol 16: 221-226.
- Foodman M, Giger U, Stebbins K, Knight D. 1989. Kartagener's syndrome in an old miniature poodle. J Small Anim Pract 30: 96-100. https://doi.org/10.1111/j.1748-5827.1989.tb01508.x
- Fulcher AS, Turner MA. 2002. Abdominal manifestations of situs anomalies in adults. Radiographics 22: 1439-1456. https://doi.org/10.1148/rg.226025016
- Handel MA, Kennedy JR. 1984. Situs inversus in homozygous mice without immotile cilia. J Hered 75: 498-498. https://doi.org/10.1093/oxfordjournals.jhered.a109995
- Jerram RM, Warman CG, Wu CT. 2006. Echocardiographic and radiographic diagnosis: complete situs inversus in a cat. Vet Radiol Ultrasound 47: 313-315. https://doi.org/10.1111/j.1740-8261.2006.00146.x
- Kartagener M. 1962. Bronchiectasis with situs inversus. Arch Pediatr 79: 193-207.
- Lee SE, Kim HY, Jung SE, Lee SC, Park KW, Kim WK. 2006. Situs anomalies and gastrointestinal abnormalities. J Pediatr Surg 41: 1237-1242. https://doi.org/10.1016/j.jpedsurg.2006.03.045
- Mayo CW, Rice RG. 1949. Situs inversus totalis: a statistical review of data on seventy-six cases with special reference to disease of the biliary tract. Arch Surg 58: 724-730. https://doi.org/10.1001/archsurg.1949.01240030734014
- Neil JA, Canapp Jr SO, Cook CR, Lattimer JC. 2002. Kartagener's syndrome in a Dachshund dog. J Am Anim Hosp Assoc 38: 45-49. https://doi.org/10.5326/0380045
- O'brien D, Moore P, Vernau W, Peauroi J, Rebhun R, Rodriguez Jr C, Skorupski K. 2013. Clinical characteristics and outcome in dogs with splenic marginal zone lymphoma. J Vet Intern Med 27: 949-954. https://doi.org/10.1111/jvim.12116
- Oui H, Kim J, Bae Y, Oh J, Park S, Lee G, Jeon S, Choi J. 2013. Computed tomography angiography of situs inversus, portosystemic shunt and multiple vena cava anomalies in a dog. J Vet Med Sci 75: 1525-1528. https://doi.org/10.1292/jvms.13-0212
- Piantedosi D, Cortese L, Meomartino L, Di Loria A, Ciaramella P. 2011. Situs inversus totalis associated with subaortic stenosis, restrictive ventricular septal defect, and tricuspid dysplasia in an adult dog. Can Vet J 52: 1231-1242.
- Reichler I, Hoerauf A, Guscetti F, Gardelle O, Stoffel MH, Jentsch B, Walt H, Arnold S. 2001. Primary ciliary dyskinesia with situs inversus totalis, hydrocephalus internus and cardiac malformations in a dog. J Small Anim Pract 42: 345-348. https://doi.org/10.1111/j.1748-5827.2001.tb02471.x
- Santos TSd, Tavares RS, Farias DLCd. 2017. Splenic marginal zone lymphoma: a literature review of diagnostic and therapeutic challenges. Rev Bras Hematol Hemoter 39: 146-154. https://doi.org/10.1016/j.bjhh.2016.09.014
- Schwart T. 2018. Large bowel. pp. 955-969. In: Donal E Thrall(ed.). Textbook of veterinarydiagnostic radiology. 7th. Elsevier. Missouri.
- Shiraiwa K, Watanabe A, Sato N, Nito M, Kobayashi Y. 1995. Case report on situs inversus totalis in two Sprague-Dawley rats. Experimental animals 44: 341-345. https://doi.org/10.1538/expanim.44.341
- Stefanello D, Valenti P, Zini E, Comazzi S, Gelain M, Roccabianca P, Avallone G, Caniatti M, Marconato L. 2011. Splenic marginal zone lymphoma in 5 dogs (2001-2008). J Vet Intern Med 25: 90-93. https://doi.org/10.1111/j.1939-1676.2010.0639.x
- Suh BJ. 2017. A case of gastric cancer with situs inversus totalis. Case Rep Oncol 10: 130-135. https://doi.org/10.1159/000456539
- Witsberger TH, Dismukes DI, Kelmer EY. 2009. Situs inversus totalis in a dog with a chronic diaphragmatic hernia. J Am Anim Hosp Assoc 45: 245-248. https://doi.org/10.5326/0450245
- Wojcik J, Grodzki T, Bielewicz M, Wojtys M, Kubisa B, Pierog J, Wojcik N. 2013. Lung cancer in situs inversus totalis (SIT)-literature review. Adv Med Sci 58: 1-8. https://doi.org/10.2478/v10039-012-0083-x