References
- Michiels C (2003) Endothelial cell functions. J Cell Physiol 196, 430-443 https://doi.org/10.1002/jcp.10333
- Markwald RR, Fitzharris TP and Smith WN (1975) Sturctural analysis of endocardial cytodifferentiation. Dev Biol 42, 160-180 https://doi.org/10.1016/0012-1606(75)90321-8
- Armstrong EJ and Bischoff J (2004) Heart valve development: endothelial cell signaling and differentiation. Circ Res 95, 459-470 https://doi.org/10.1161/01.RES.0000141146.95728.da
- Nakajima Y, Yamagishi T, Hokari S and Nakamura H (2000) Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: roles of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP). Anat Rec 258, 119-127 https://doi.org/10.1002/(SICI)1097-0185(20000201)258:2<119::AID-AR1>3.0.CO;2-U
- van Meeteren LA and ten Dijke P (2012) Regulation of endothelial cell plasticity by TGF-beta. Cell Tissue Res 347, 177-186 https://doi.org/10.1007/s00441-011-1222-6
- Krenning G, Zeisberg EM and Kalluri R (2010) The origin of fibroblasts and mechanism of cardiac fibrosis. J Cell Physiol 225, 631-637 https://doi.org/10.1002/jcp.22322
- Zeisberg EM, Potenta S, Xie L, Zeisberg M and Kalluri R (2007) Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res 67, 10123-10128 https://doi.org/10.1158/0008-5472.CAN-07-3127
- Ghosh AK, Quaggin SE and Vaughan DE (2013) Molecular basis of organ fibrosis: potential therapeutic approaches. Exp Biol Med (Maywood) 238, 461-481 https://doi.org/10.1177/1535370213489441
- Arciniegas E, Frid MG, Douglas IS and Stenmark KR (2007) Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 293, L1-L8 https://doi.org/10.1152/ajplung.00378.2006
- Cooley BC, Nevado J, Mellad J et al (2014) TGF-beta signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling. Sci Transl Med 6, 227ra34 https://doi.org/10.1126/scitranslmed.3006927
- Chen PY, Qin L, Barnes C et al (2012) FGF regulates TGF-beta signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep 2, 1684-1696 https://doi.org/10.1016/j.celrep.2012.10.021
- Yao Y, Jumabay M, Ly A, Radparvar M, Cubberly MR and Bostrom KI (2013) A role for the endothelium in vascular calcification. Circ Res 113, 495-504 https://doi.org/10.1161/CIRCRESAHA.113.301792
- Chen PY, Qin L, Baeyens N et al (2015) Endothelial-tomesenchymal transition drives atherosclerosis progression. J Clin Invest 125, 4514-4528 https://doi.org/10.1172/JCI82719
- Maddaluno L, Rudini N, Cuttano R et al (2013) EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature 498, 492-496 https://doi.org/10.1038/nature12207
- Potenta S, Zeisberg E and Kalluri R (2008) The role of endothelial-to-mesenchymal transition in cancer progression. Br J Cancer 99, 1375-1379 https://doi.org/10.1038/sj.bjc.6604662
- Kovacic JC, Mercader N, Torres M, Boehm M and Fuster V (2012) Epithelial-to-mesenchymal and endothelial-tomesenchymal transition: from cardiovascular development to disease. Circulation 125, 1795-1808 https://doi.org/10.1161/CIRCULATIONAHA.111.040352
- Lee A, McLean D, Choi J, Kang H, Chang W and Kim J (2014) Therapeutic implications of microRNAs in pulmonary arterial hypertension. BMB Rep 47, 311-317 https://doi.org/10.5483/BMBRep.2014.47.6.085
- Kim JD, Lee A, Choi J et al (2015) Epigenetic modulation as a therapeutic approach for pulmonary arterial hypertension. Exp Mol Med 47, e175 https://doi.org/10.1038/emm.2015.45
- Hobert O (2008) Gene regulation by transcription factors and microRNAs. Science 319, 1785-1786 https://doi.org/10.1126/science.1151651
- Pardali E, Sanchez-Duffhues G, Gomez-Puerto MC and Ten Dijke P (2017) TGF-beta-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases. Int J Mol Sci 18
- Noseda M, McLean G, Niessen K et al (2004) Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circ Res 94, 910-917 https://doi.org/10.1161/01.RES.0000124300.76171.C9
- Perez L, Munoz-Durango N, Riedel CA et al (2017) Endothelial-to-mesenchymal transition: Cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions. Cytokine Growth Factor Rev 33, 41-54 https://doi.org/10.1016/j.cytogfr.2016.09.002
- Welch-Reardon KM, Wu N and Hughes CC (2015) A role for partial endothelial-mesenchymal transitions in angiogenesis? Arterioscler Thromb Vasc Biol 35, 303-308 https://doi.org/10.1161/ATVBAHA.114.303220
- Nagai T, Kanasaki M, Srivastava SP et al (2014) N-acetylseryl-aspartyl-lysyl-proline inhibits diabetes-associated kidney fibrosis and endothelial-mesenchymal transition. Biomed Res Int 2014, 696475
- Zhang H, Hu J and Liu L (2017) MiR-200a modulates TGF-beta1-induced endothelial-to-mesenchymal shift via suppression of GRB2 in HAECs. Biomed Pharmacother 95, 215-222 https://doi.org/10.1016/j.biopha.2017.07.104
- Correia AC, Moonen JR, Brinker MG and Krenning G (2016) FGF2 inhibits endothelial-mesenchymal transition through microRNA-20a-mediated repression of canonical TGF-beta signaling. J Cell Sci 129, 569-579 https://doi.org/10.1242/jcs.176248
- Sun Y, Cai J, Yu S, Chen S, Li F and Fan C (2016) MiR-630 Inhibits Endothelial-Mesenchymal Transition by Targeting Slug in Traumatic Heterotopic Ossification. Sci Rep 6, 22729 https://doi.org/10.1038/srep22729
- Kanasaki K, Shi S, Kanasaki M et al (2014) Linagliptinmediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to-mesenchymal transition in a therapeutic regimen. Diabetes 63, 2120-2131 https://doi.org/10.2337/db13-1029
- Korpal M, Lee ES, Hu G and Kang Y (2008) The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 283, 14910-14914 https://doi.org/10.1074/jbc.C800074200
- Zhang S, Weinheimer C, Courtois M et al (2003) The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis. J Clin Invest 111, 833-841 https://doi.org/10.1172/JCI16290
- Ge S, Xie J, Liu F, He J and He J (2015) MicroRNA-19b reduces hepatic stellate cell proliferation by targeting GRB2 in hepatic fibrosis models in vivo and in vitro as part of the inhibitory effect of estradiol. J Cell Biochem 116, 2455-2464 https://doi.org/10.1002/jcb.25116
- Fafeur V, Terman BI, Blum J and Bohlen P (1990) Basic FGF treatment of endothelial cells down-regulates the 85-KDa TGF beta receptor subtype and decreases the growth inhibitory response to TGF-beta 1. Growth Factors 3, 237-245 https://doi.org/10.3109/08977199009043908
- Papetti M, Shujath J, Riley KN and Herman IM (2003) FGF-2 antagonizes the TGF-beta1-mediated induction of pericyte alpha-smooth muscle actin expression: a role for myf-5 and Smad-mediated signaling pathways. Invest Ophthalmol Vis Sci 44, 4994-5005 https://doi.org/10.1167/iovs.03-0291
- Ramos C, Becerril C, Montano M et al (2010) FGF-1 reverts epithelial-mesenchymal transition induced by TGF-{beta}1 through MAPK/ERK kinase pathway. Am J Physiol Lung Cell Mol Physiol 299, L222-231 https://doi.org/10.1152/ajplung.00070.2010
- Lee JG, Ko MK and Kay EP (2012) Endothelial mesenchymal transformation mediated by IL-1beta-induced FGF-2 in corneal endothelial cells. Exp Eye Res 95, 35-39 https://doi.org/10.1016/j.exer.2011.08.003
- Lee HT, Lee JG, Na M and Kay EP (2004) FGF-2 induced by interleukin-1 beta through the action of phosphatidylinositol 3-kinase mediates endothelial mesenchymal transformation in corneal endothelial cells. J Biol Chem 279, 32325-32332 https://doi.org/10.1074/jbc.M405208200
- Aird WC (2007) Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. Circ Res 100, 158-173 https://doi.org/10.1161/01.RES.0000255691.76142.4a
- Lagendijk AK, Goumans MJ, Burkhard SB et al (2011) MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production. Circ Res 109, 649-657 https://doi.org/10.1161/CIRCRESAHA.111.247635
- Bayoumi AS, Teoh JP, Aonuma T et al (2017) MicroRNA-532 protects the heart in acute myocardial infarction, and represses prss23, a positive regulator of endothelial-to-mesenchymal transition. Cardiovasc Res 113, 1603-1614 https://doi.org/10.1093/cvr/cvx132
- Bijkerk R, de Bruin RG, van Solingen C et al (2012) MicroRNA-155 functions as a negative regulator of RhoA signaling in TGF-beta-induced endothelial to mesenchymal transition. Microrna 1, 2-10 https://doi.org/10.2174/2211536611201010002
- Ruderman NB, Williamson JR and Brownlee M (1992) Glucose and diabetic vascular disease. FASEB J 6, 2905-2914 https://doi.org/10.1096/fasebj.6.11.1644256
- Cao Y, Feng B, Chen S, Chu Y and Chakrabarti S (2014) Mechanisms of endothelial to mesenchymal transition in the retina in diabetes. Invest Ophthalmol Vis Sci 55, 7321-7331 https://doi.org/10.1167/iovs.14-15167
- Feng B, Cao Y, Chen S, Chu X, Chu Y and Chakrabarti S (2016) miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy. Diabetes 65, 768-779 https://doi.org/10.2337/db15-1033
- Geng HZ and Guan J (2017) MiR-18a-5p inhibits endothelial mesenchymal transition and cardiac fibrosis through the Notch2 pathway. Biochem Biophys Res Commun 491, 329-336 https://doi.org/10.1016/j.bbrc.2017.07.101
- Kumarswamy R, Volkmann I, Jazbutyte V, Dangwal S, Park DH and Thum T (2012) Transforming Growth Factor-beta-Induced Endothelial-to-Mesenchymal Transition Is Partly Mediated by MicroRNA-21. Arterioscler Thromb Vasc Biol 32, 361-369 https://doi.org/10.1161/ATVBAHA.111.234286
- Ghosh AK, Nagpal V, Covington JW, Michaels MA and Vaughan DE (2012) Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): differential expression of microRNAs during EndMT. Cell Signal 24, 1031-1036 https://doi.org/10.1016/j.cellsig.2011.12.024
- Suzuki HI, Katsura A, Mihira H, Horie M, Saito A and Miyazono K (2017) Regulation of TGF-beta-mediated endothelial-mesenchymal transition by microRNA-27. J Biochem 161, 417-420 https://doi.org/10.1093/jb/mvx017
- Li L, Kim IK, Chiasson V, Chatterjee P and Gupta S (2017) NF-kappaB mediated miR-130a modulation in lung microvascular cell remodeling: Implication in pulmonary hypertension. Exp Cell Res 359, 235-242 https://doi.org/10.1016/j.yexcr.2017.07.024
- Xu YP, He Q, Shen Z et al (2017) MiR-126a-5p is involved in the hypoxia-induced endothelial-to-mesenchymal transition of neonatal pulmonary hypertension. Hypertens Res 40, 552-561 https://doi.org/10.1038/hr.2017.2
- Kendall RT and Feghali-Bostwick CA (2014) Fibroblasts in fibrosis: novel roles and mediators. Front Pharmacol 5, 123
- Zeisberg EM, Tarnavski O, Zeisberg M et al (2007) Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med 13, 952-961 https://doi.org/10.1038/nm1613
- Lin F, Wang N and Zhang TC (2012) The role of endothelial-mesenchymal transition in development and pathological process. IUBMB Life 64, 717-723 https://doi.org/10.1002/iub.1059
- He M, Chen Z, Martin M et al (2017) miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease. Circ Res 120, 354-365 https://doi.org/10.1161/CIRCRESAHA.116.310233
- Guo Y, Li P, Bledsoe G, Yang ZR, Chao L and Chao J (2015) Kallistatin inhibits TGF-beta-induced endothelialmesenchymal transition by differential regulation of microRNA-21 and eNOS expression. Exp Cell Res 337, 103-110 https://doi.org/10.1016/j.yexcr.2015.06.021
- Shen B, Hagiwara M, Yao YY, Chao L and Chao J (2008) Salutary effect of kallistatin in salt-induced renal injury, inflammation, and fibrosis via antioxidative stress. Hypertension 51, 1358-1365 https://doi.org/10.1161/HYPERTENSIONAHA.107.108514
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