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A Clinical Study of 148 Patients with Soyangin Vitiligo

소양인(少陽人) 백반증 148예의 임상적 고찰

  • Received : 2017.12.29
  • Accepted : 2018.02.09
  • Published : 2018.02.25

Abstract

Objectives : The purpose of this study is to evaluate the clinical aspects of patients with Soyangin vitiligo. Methods : This clinical investigation was made with 148 Soyangin Vitiligo patients who visited Haneulmaeum Oriental Medicine Clinic (Incheon) from July 1st 2007 to June 30th 2017. Results & Conclusions : 1. There were 73 males(49.3%) and 75 females(50.7%). 2. The Mean age at the first visit was 36.1 years(male: 36.4, female: 35.8). 3. The Mean age of onset was 27.9 years(male: 28.6, female: 27.4). 4. The mean duration of the disease was 8.0 years(male: 7.8, female: 8.3). 5. Of the 148 patients, 41(27.7%) had the symmetric lesions and 107(72.3%) had the asymmetric vitiligo lesions. Of the patients with asymmetric vitiligo lesions, 46(31.1%) had the localized lesions and 26(17.6%) had the segmental lesions and 35(24.3%) had the multiple lesions. 6. The most common site of initial involvement of the vitiligo was the face (39.2%). 7. The most common site of the vitiligo lesions was the face(49.3%). 8. Familial history was obtained in 12 patients(8.1%). 9. There was no known precipitating factor in most cases(89.4%). 10. Thyroid disease was the most common associated disease. 11. The progression of vitiligo was present in 92 patients(62.2%).

Keywords

References

  1. Ortonne JP, Mosher DB, Fitzpatrick TB. Hypomelanotic disorders: vitiligo and other hypomelanoses fo hair and skin. 6th ed. New York:Plenum. 1983:120-310.
  2. Lerner AB. Vitilgo. J Invest Dermatol. 1959;32:285-310. https://doi.org/10.1038/jid.1959.49
  3. Masher DB, Fitzpatrick TB, Ortonne JP. Abnormalities of pigmentation. In: Fitzpatrick TB, Eisen AZ, Wolff K, et al, editors. Dermatology in General Medicine. 2nd ed. New York:McGraw-Hill Book. 1979:582-90.
  4. Betterie C, Caretto A, De Zio A, Pedini B, Velle-Fornasa. Incidence and significance of organ-specific autoimmune disorder in patients with vitiligo. Dermatologica. 1985;171:419-23. https://doi.org/10.1159/000249466
  5. Koga M. Vitiligo: a new classification and therapy. Br J Dermatol. 1977;97:255-61. https://doi.org/10.1111/j.1365-2133.1977.tb15180.x
  6. Lerner AB. On the etiology of vitiligo and gray hair. Am J Med. 1971;51:147-56.
  7. Karin US, Mark RP, John MW. Free fadical reduction by Thioredoxin reductase at the surface of normal and vitiliginous haman keratinocytes. J Invest Dermatol. 1986;87:728-32. https://doi.org/10.1111/1523-1747.ep12456848
  8. Grimes PE, Ghoneum M, Stockton T, Payne C, Kelly AP, Alfred L. T cell profiles in vitiligo. J Am Acad Dermatol. 1986;14:196-201. https://doi.org/10.1016/S0190-9622(86)70021-2
  9. Mosher DB, Fitzpatrick TB, Ortonne JP, Hori Y. Hypomelanoses and hypermelanoses. In: Freedberg IM, Eisen AZ, Wolff K, editors. Fitzpatrick's dermatology in general medicine. 5th ed. New York: McGraw-Hill Book. 1999;945-1017.
  10. Cho S, Kang HC, Hahm JH. Characteristics of vitiligo in Korean children. Pediatr Dermatol. 2000;17:189-93. https://doi.org/10.1046/j.1525-1470.2000.01749.x
  11. Huggins RH, Schwartz RA, Janniger CK. Childhood vitiligo. Cutis. 2007;79:277-80.
  12. Koga M, Tango T. Clinical features and course of type A and type B vitiligo. Br J Dermatol. 1988;118:223-8. https://doi.org/10.1111/j.1365-2133.1988.tb01778.x
  13. Jeon EK, Park YO, Kim CD, Seo YJ, Lee JH, Park JK. The clinical significance of symmetry in the distribution of vitiligo lesions. Korean J Dermatol. 2008;46:40-5.
  14. Jeon EK, Park YO, Seo YJ, Lee JH, Park JK. Assessment of the Quality of Life in Vitiligo Patients. Korean J Dermatol. 2008;46:74-80.
  15. Hong SY, Yie UH. Principles of Sasang Medicine. Seoul:Haenglim. 1994:134-6, 275-8,301,325-6.
  16. Ji SY, Kwon YK, Shin SK. The study on the oriental and western Medical literatures of vitiligo. J of Jaehan Oriental Medical academy. 1999;4(1):262-85.
  17. Park SR, Yun JI, Lim SD. Clinical study of 217 cases of vitiligo. Korean J Dermatol. 1981;19:171-82.
  18. Park KC, Youn JI, Lee YS. Clinical study of 326 cases of vitiligo. Korean J Dermatol. 1988;26:200-5.
  19. Yu HJ, Park KC, Ahn JS. Clinical study of vitiligo. Korean J Dermatol. 1998;36:1037-42.
  20. Levai M. A study of certain contributory factors in the development of vitiligo in South Indian patients. Arch Dermatol. 1958;78:364-71. https://doi.org/10.1001/archderm.1958.01560090080017
  21. Kim YC, Kin W, Hann SK. The genetics of vitiligo in Korean patients. Korean J Dermatol. 1996;34:968-72.
  22. Halder RM, Taliaferro SJ. Vitiligo. In: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, editors. Fitzpatrick's dermatology in general medicine. 7th ed. New York:McGraw-Hill. 2008:616-22.
  23. Halder RM, Grimes PE, Cowan CA, Enterline JA, Chakrabarti SG, Kenney JA Jr. Childhood vitiligo. J Am Acad Dermatol. 1987;16:948-54. https://doi.org/10.1016/S0190-9622(87)70119-4
  24. Kovacs SO. Vitiligo. J Am Acad Dermatol. 1998;38:647-66. https://doi.org/10.1016/S0190-9622(98)70194-X
  25. Cunliffe WJ, Hall R, Newell DJ, et al. Vitiligo, thyroid disease and autoimmunity. Br J Dermatol. 1968;80:135-9. https://doi.org/10.1111/j.1365-2133.1968.tb12282.x
  26. Kim TH. The recent therapeutics of vitiligo. Korean J Dermatol. 2007;59:113.