Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제44권6호
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  • Pages.289-292
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  • 2018
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
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Gingival crevicular fluid levels of sclerostin in chronic periodontitis and healthy subjects

  • Esfahrood, Zeinab Rezaei (Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences) ;
  • Yadegari, Zahra (Department of Dental Biomaterials, School of Dentistry, Shahid Beheshti University of Medical Sciences) ;
  • Veysari, Setareh Kazemi (School of Dentistry, Shahid Beheshti University of Medical Sciences) ;
  • Kadkhodazadeh, Mahdi (Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences)
  • 투고 : 2018.01.16
  • 심사 : 2018.03.12
  • 발행 : 2018.12.31
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초록

Objectives: Chronic periodontitis is a common inflammatory disease of the oral cavity that causes destruction of periodontal tissues and bone around the teeth. Sclerostin is a protein encoded by the SOST gene. In this study, gingival crevicular fluid (GCF) levels of sclerostin in patients with chronic periodontitis were compared with those of healthy subjects. Materials and Methods: In this case-control study, a total of 40 subjects were enrolled and divided into the healthy group (n=23) and chronic periodontitis group (n=17). GCF samples were collected, and the concentration of sclerostin was evaluated using enzyme-linked immunosorbent assay. Comparison of significance between groups was assessed using Mann-Whitney U test. Results: Sclerostin concentration was significantly higher in the chronic periodontitis group compared with the healthy group (P<0.005). Conclusion: Despite the limitations of this study, sclerostin can be a possible marker for assessment of periodontal health status.

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참고문헌

  1. Kornman KS, Page RC, Tonetti MS. The host response to the microbial challenge in periodontitis: assembling the players. Periodontol 2000 1997;14:33-53. https://doi.org/10.1111/j.1600-0757.1997.tb00191.x
  2. Bascones-Martinez A, Munoz-Corcuera M, Noronha S, Mota P, Bascones-Ilundain C, Campo-Trapero J. Host defence mechanisms against bacterial aggression in periodontal disease: basic mechanisms. Med Oral Patol Oral Cir Bucal 2009;14:e680-5.
  3. Kumar PS, Griffen AL, Barton JA, Paster BJ, Moeschberger ML, Leys EJ. New bacterial species associated with chronic periodontitis. J Dent Res 2003;82:338-44. https://doi.org/10.1177/154405910308200503
  4. Buduneli N, Kinane DF. Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis. J Clin Periodontol 2011;38 Suppl 11:85-105. https://doi.org/10.1111/j.1600-051X.2010.01670.x
  5. Champagne CM, Buchanan W, Reddy MS, Preisser JS, Beck JD, Offenbacher S. Potential for gingival crevice fluid measures as predictors of risk for periodontal diseases. Periodontol 2000 2003;31:167-80. https://doi.org/10.1034/j.1600-0757.2003.03110.x
  6. Robling AG, Niziolek PJ, Baldridge LA, Condon KW, Allen MR, Alam I, et al. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem 2008;283:5866-75. https://doi.org/10.1074/jbc.M705092200
  7. Winkler DG, Sutherland MK, Geoghegan JC, Yu C, Hayes T, Skonier JE, et al. Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO J 2003;22:6267-76. https://doi.org/10.1093/emboj/cdg599
  8. Silverman SL. Sclerostin. J Osteoporos 2010;2010:941419.
  9. Poole KE, van Bezooijen RL, Loveridge N, Hamersma H, Papapoulos SE, Lowik CW, et al. Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation. FASEB J 2005;19:1842-4. https://doi.org/10.1096/fj.05-4221fje
  10. Atkins GJ, Rowe PS, Lim HP, Welldon KJ, Ormsby R, Wijenayaka AR, et al. Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism. J Bone Miner Res 2011;26:1425-36. https://doi.org/10.1002/jbmr.345
  11. Ren Y, Han X, Ho SP, Harris SE, Cao Z, Economides AN, et al. Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model. FASEB J 2015;29:2702-11. https://doi.org/10.1096/fj.14-265496
  12. Balli U, Aydogdu A, Dede FO, Turer CC, Guven B. Gingival crevicular fluid levels of sclerostin, osteoprotegerin, and receptor activator of nuclear factor-${\kappa}B$ ligand in periodontitis. J Periodontol 2015;86:1396-404. https://doi.org/10.1902/jop.2015.150270
  13. Li X, Ominsky MS, Niu QT, Sun N, Daugherty B, D'Agostin D, et al. Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res 2008;23:860-9. https://doi.org/10.1359/jbmr.080216
  14. Griffiths GS. Formation, collection and significance of gingival crevice fluid. Periodontol 2000 2003;31:32-42. https://doi.org/10.1034/j.1600-0757.2003.03103.x
  15. Li X, Ominsky MS, Warmington KS, Morony S, Gong J, Cao J, et al. Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J Bone Miner Res 2009;24:578-88. https://doi.org/10.1359/jbmr.081206
  16. Ominsky MS, Vlasseros F, Jolette J, Smith SY, Stouch B, Doellgast G, et al. Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength. J Bone Miner Res 2010;25:948-59. https://doi.org/10.1002/jbmr.14
  17. Yang X, Han X, Shu R, Jiang F, Xu L, Xue C, et al. Effect of sclerostin removal in vivo on experimental periodontitis in mice. J Oral Sci 2016;58:271-6. https://doi.org/10.2334/josnusd.15-0690
  18. Taut AD, Jin Q, Chung JH, Galindo-Moreno P, Yi ES, Sugai JV, et al. Sclerostin antibody stimulates bone regeneration after experimental periodontitis. J Bone Miner Res 2013;28:2347-56. https://doi.org/10.1002/jbmr.1984

피인용 문헌

  1. The roles of osteocytes in alveolar bone destruction in periodontitis vol.18, pp.1, 2018, https://doi.org/10.1186/s12967-020-02664-7
  2. Comparison of Sclerostin Levels in Gingival Crevicular Fluid before and after Nonsurgical Therapy in Smokers and Nonsmokers with Chronic Periodontitis vol.12, pp.5, 2018, https://doi.org/10.5005/jp-journals-10015-1853
  3. Sclerostin and its role as a bone modifying agent in periodontal disease vol.63, pp.2, 2021, https://doi.org/10.1016/j.job.2021.04.002