Journal of Electrochemical Science and Technology

The Korean Electrochemical Society (한국전기화학회)
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Electro-Catalytic Behavior of an Antiarrhythmic Drug, Procainamide and its Electro-Analytical Applications

  • Abbar, Jyothi C. (Sri Venkateshwara College of Engineering) ;
  • Meti, Manjunath D. (College of Life Sciences and Oceanography, Shenzhen University) ;
  • Nandibewoor, Sharanappa T. (P. G. Department of Studies in Chemistry, Karnatak University)
  • Received : 2018.06.05
  • Accepted : 2018.07.31
  • Published : 2018.12.31
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Abstract

The electrocatalytic oxidative behavior of an antiarrhythmic drug, procainamide hydrochloride (PAH) at the gold electrode surface has been examined using different voltammetric methods like cyclic, linear-sweep and differential pulse voltammetry. Voltammograms obtained in this study reveal that the electrode exhibit excellent electrocatalytic activity towards oxidation of the drug. The parameters that can affect the peak current at different pH, scan rate and concentration were evaluated. The number of electrons transferred was calculated. The current displayed a wide linear response ranging from 0.5 to $30.0{\mu}M$ with a limit of detection of 56.4 nM. The impact of potential interfering agents was also studied. The electrode displayed wide advantages such as simple sample preparation, appreciable repeatability, reproducibility and also high sensitivity. Furthermore, the feasibility of the proposed method was successfully demonstrated by determining PAH in the spiked human biological sample.

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