DOI QR코드

DOI QR Code

Immunomodulatory and Anti-Inflammatory Phytochemicals for the Treatment of Inflammatory Bowel Disease (IBD) - Turning Strong Rationale into Strong Evidence? -

  • Sodagari, Hamid Reza (Young Researchers and Elite Club, Karaj Branch, Islamic Azad University) ;
  • Aryan, Zahra (Students' Scientific Research Center, Tehran University of Medical Sciences) ;
  • Abdolghaffari, Amir Hossein (Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR) ;
  • Rezaei, Nima (Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences) ;
  • Sahebkar, Amirhossein (Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences)
  • Received : 2017.09.21
  • Accepted : 2018.11.14
  • Published : 2018.12.31

Abstract

Keywords

References

  1. Hodson R. Inflammatory bowel disease. Nature. 2016;540(7634):S97-S97. https://doi.org/10.1038/540S97a
  2. Ananthakrishnan AN. Nutritional Management of Inflammatory Bowel Diseases; 2016.
  3. Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nature Genetics. 2008;40(8):955-962. https://doi.org/10.1038/ng.175
  4. Cho JH. The genetics and immunopathogenesis of inflammatory bowel disease. Nature Reviews Immunology. 2008;8(6):458-466. https://doi.org/10.1038/nri2340
  5. Hedayat M, Netea MG, Rezaei N. Targeting of Tolllike receptors: a decade of progress in combating infectious diseases. The Lancet infectious diseases. 2011;11(9):702-712. https://doi.org/10.1016/S1473-3099(11)70099-8
  6. Abraham C, Cho J. Interleukin-23/Th17 pathways and inflammatory bowel disease. Inflammatory bowel diseases. 2009;15(7):1090-1100. https://doi.org/10.1002/ibd.20894
  7. Kamada N, Seo SU, Chen GY, Nunez G. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol. 2013;13(5):321-335. https://doi.org/10.1038/nri3430
  8. Gonzalez-Sarrias A, Espin JC, Tomas-Barberan FA, Garcia-Conesa MT. Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins. Molecular nutrition & food research. 2009;53(6):686-698. https://doi.org/10.1002/mnfr.200800150
  9. Veiga P, Gallini CA, Beal C, Michaud M, Delaney ML, DuBois A, et al. Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proceedings of the National Academy of Sciences. 2010;107(42):18132-18137. https://doi.org/10.1073/pnas.1011737107
  10. Yang F, Oz HS, Barve S, De Villiers WJ, McClain CJ, Varilek GW. The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-${\kappa}B$ activation by inhibiting $l{\kappa}B$ kinase activity in the intestinal epithelial cell line IEC-6. Molecular Pharmacology. 2001;60(3):528-533.
  11. Rosillo MA, Sanchez-Hidalgo M, Cardeno A, Aparicio-Soto M, Sanchez-Fidalgo S, Villegas I, et al. Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats. Pharmacological Research. 2012;66(3):235-242. https://doi.org/10.1016/j.phrs.2012.05.006
  12. Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Digestive diseases and sciences. 2005;50(11):2191-2193. https://doi.org/10.1007/s10620-005-3032-8
  13. Vezza T, Rodriguez-Nogales A, Algieri F, Utrilla MP, Rodriguez-Cabezas ME, Galvez J. Flavonoids in inflammatory bowel disease: a review. Nutrients. 2016;8(4):211. https://doi.org/10.3390/nu8040211
  14. Dodda D, Chhajed R, Mishra J. Protective effect of quercetin against acetic acid induced inflammatory bowel disease (IBD) like symptoms in rats: Possible morphological and biochemical alterations. Pharmacological Reports. 2014;66(1):169-173. https://doi.org/10.1016/j.pharep.2013.08.013
  15. Marchi P, Paiotti APR, Neto RA, Oshima CTF, Ribeiro DA. Concentrated grape juice ($G8000^{TM}$) reduces immunoexpression of iNOS, TNF-alpha, COX-2 and DNA damage on 2, 4, 6-trinitrobenzene sulfonic acid-induced-colitis. Environmental toxicology and pharmacology. 2014;37(2):819-827. https://doi.org/10.1016/j.etap.2014.02.006
  16. Medda R, Lyros O, Schmidt JL, Jovanovic N, Nie L, Link BJ, et al. Anti inflammatory and anti angiogenic effect of black raspberry extract on human esophageal and intestinal microvascular endothelial cells. Microvascular research. 2015;97:167-180. https://doi.org/10.1016/j.mvr.2014.10.008