Journal of Animal Science and Technology

Korean Society of Animal Sciences and Technology (한국축산학회)
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Effects of dietary supplementation of a lipid-coated zinc oxide product on the fecal consistency, growth, and morphology of the intestinal mucosa of weanling pigs

  • Byun, Young-Jin (Department of Animal Resources Technology, Gyeongnam National University of Science and Technology) ;
  • Lee, Chul Young (Department of Animal Resources Technology, Gyeongnam National University of Science and Technology) ;
  • Kim, Myeong Hyeon (Department of Animal Resources Technology, Gyeongnam National University of Science and Technology) ;
  • Jung, Dae Yun (Department of Animal Resources Technology, Gyeongnam National University of Science and Technology) ;
  • Han, Jeong Hee (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Jang, Insurk (Department of Animal Science and Biotechnology, Gyeongnam National University of Science and Technology) ;
  • Song, Young Min (Department of Animal Resources Technology, Gyeongnam National University of Science and Technology) ;
  • Park, Byung-Chul (Graduate School of International Agricultural Technology, Institute of Green Bio Science and Technology, Seoul National University)
  • Received : 2017.06.19
  • Accepted : 2017.11.03
  • Published : 2018.01.31
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Abstract

Background: Dietary supplementation of zinc oxide (ZnO) to 2000 to 4000 mg/kg is known to be effective for the prevention and treatment of post-weaning diarrhea in the pig. Such a 'pharmacological' supplementation, however, can potentially result in environmental pollution of the heavy metal, because dietary ZnO is mostly excreted unabsorbed. Two experiments (Exp.) were performed in the present study to determine the effects of a lipid-coated ZnO supplement Shield Zn (SZ) compared with those of ZnO. Methods: In Exp. 1, a total of 240 21-day-old weanling pigs were fed a diet supplemented with 100 mg Zn/kg as ZnO (ZnO-100), ZnO-2500, SZ-100, or SZ-200 in 24 pens for 14 days on a farm with its post-weaning pigs exhibiting a low incidence of diarrhea. Exp. 2 was performed using 192 24-day-old piglets as in Exp. 1 on a different farm, which exhibited a high incidence of diarrhea. Results: In Exp. 1, fecal consistency (diarrhea) score (FCS) was less for the ZnO-2500 and SZ-200 groups than for the SZ-100 group (P < 0.05), with no difference between the SZ-100 and ZnO-100 groups. Both average daily gain (ADG) and gain:feed ratio were less for the SZ-200 group than for the ZnO-2500 group, with no difference between the ZnO-100 group and SZ-100 or SZ-200 group. The villus height (VH), crypt depth (CD), and VH:CD ratio of the intestinal mucosa were not influenced by the treatment. In Exp. 2, FCS was lowest for the ZnO-2500 group, with no difference among the other groups. However, neither the ADG nor gain:feed ratio was influenced by the treatment. Conclusion: Results suggest that physiological SZ supplementation has less beneficial effects than pharmacological ZnO for the alleviation of diarrhea irrespective of its severity and for promoting growth without influencing their integrity of the intestinal mucosal structures with little advantage over physiological ZnO in weanling pigs with a small pen size.

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References

  1. Lalles JP, Bosi P, Smidt H, Stokes CR. Nutritional management of gut health in pigs around weaning. Proc Nutr Soc. 2007;66:260-8. https://doi.org/10.1017/S0029665107005484
  2. Weary DM, Jasper JJ, Hotzel MJ. Understanding weaning stress. Appl Anim Behav Sci. 2008;110:24-41. https://doi.org/10.1016/j.applanim.2007.03.025
  3. Campbell JM, Creshaw JD, Polo J. The biological stress of early weaned piglets. J Anim Sci Biotechnol. 2013;4:19. https://doi.org/10.1186/2049-1891-4-19
  4. Hill GM, Mahan DC, Carter SD, Cromwell GL, Ewan RC, Harrold RL, Lewis AJ, Miller PS, Shurson GC, Veum TL. Effect of pharmacological concentrations of zinc oxide with or without the inclusion of an antibacterial agent on nursery pig performance. J Anim Sci. 2001;79:934-41. https://doi.org/10.2527/2001.794934x
  5. Pluske JR, Pethick DW, Hopwood DE, Hampson DJ. Nutritional influences on some major enteric bacterial diseases of pigs. Nutr Res Rev. 2002;25:333-71.
  6. Willing BP, Malik G, Van Kessel AG. Nutrition and gut health. In: Chiba LI, editor. Sustainable swine nutrition. Oxford, UK: John Wiley & Sons, Inc.; 2013. p. 197-213.
  7. Kim JC, Hansen CF, Mullan BP, Pluske JR. Nutrition and pathology of weaner pigs: nutritional strategies to support barrier function in the gastrointestinal tract. Anim Feed Sci Technol. 2012;173:3-16. https://doi.org/10.1016/j.anifeedsci.2011.12.022
  8. Heo JM, Opapeju FO, Pluske JR, Kim JC, Hampson DJ, Nyachoti CM. Gastrointstinal health and function in weaned pigs: a review of feeding strategies to control post-weaning diarrhoea without using in-feed antimicrobial compounds. J Anim Physiol Anim Nutr. 2013;97:207-37. https://doi.org/10.1111/j.1439-0396.2012.01284.x
  9. Pekas JC. Zinc 65 metabolism: gastrointestinal secretion by the pig. Am J Phys. 1966;211:407-13.
  10. Hill GM. Minerals and mineral utilization in swine. In: Chiba LI, editor. Sustainable swine nutrition. Oxford, UK: John Wiley & Sons, Inc.; 2013. p. 173-95.
  11. Commission Regulation (EC) No 1334/2003. Amending the conditions for authorization of a number of additives in feedingstuffs belonging to the group of trace elements. Official J Eur Union. 2003;L187:11-15.
  12. Kwon CH, Lee CY, Han SY, Kim SJ, Park BC, Jang I, Han JH. Effects of dietary supplementation of lipid-encapsulated zinc oxide on colibacillosis, growth and intestinal morphology in weaned piglets challenged with enterotoxigenic Escherichia coli. Anim Sci J. 2014;85:805-13. https://doi.org/10.1111/asj.12215
  13. Kim SJ, Kwon CH, Park BC, Lee CY, Han JH. Effects of a lipid-encapsulated zinc oxide dietary supplement on growth parameters and intestinal morphology in weanling pigs artificially infected with enterotoxigenic Escherichia coli. J Anim Sci Technol. 2015;57:4.
  14. Jang I, Kwon CH, Ha DM, Jung DY, Kang SY, Park MJ, Han JH, Park BC, Lee CY. Effects of a lipid-encapsulated zinc oxide supplement on growth performance and intestinal morphology and digestive enzyme activities in weanling pigs. J Anim Sci Technol. 2014;56:29.
  15. Park BC, Jung DY, Kang SY, Ko YH, Ha DM, Kwon CH, Park MJ, Han JH, Jang I, Lee CY. Effects of dietary supplementation of a zinc oxide product encapsulated with lipid on growth performance, intestinal morphology, and digestive enzyme activities in weanling pigs. Anim Feed Sci Technol. 2015;200:112-7. https://doi.org/10.1016/j.anifeedsci.2014.11.016
  16. NIAS. National Institute of Animal Science. Korean feeding standard for swine. revised edn. NIAS, Rural Development Administration, Republic of Korea.
  17. Lee CY, Lim JW, Ko YH, Kang SY, Park MJ, Ko T, Lee JH, Hyun Y, Jeong KS, Jang IS. Intestinal growth and development of weanling pigs in response to dietary supplementation of antibiotics, phytogenic products and brewer's yeast plus bacillus spores. J Anim Sci Technol. 2011;53:227-35. https://doi.org/10.5187/JAST.2011.53.3.227
  18. Cho JH, Upadhaya SD, Kim IH. Effects of dietary supplementation of modified zinc oxide on growth performance, nutrient digestibility, blood profiles, fecal microbial shedding an fecal score in weanling pigs. Anim Sci J. 2015;86:617-23. https://doi.org/10.1111/asj.12329
  19. Shen J, Chen Y, Wang Z, Zhou A, He M, Mao L, Zou H, Peng Q, Xue B, Wang L, Zhang X, Wu S, Lv Y. Coated zinc oxide improves intestinal immunity function and regulates microbiota composition in weaned piglets. Br J Nutr. 2014;111:2123-34. https://doi.org/10.1017/S0007114514000300
  20. Wang C, Xie P, Liu LL, Dong XY, JJ L, Zou XT. Use of lower level of capsulated zinc oxide as an alternative to pharmacological dose of zinc oxide for weaned piglets. Asian J Anim Vet Adv. 2012;7:1290-300. https://doi.org/10.3923/ajava.2012.1290.1300
  21. Carlson MS, Hill GM, Link JE. Early- and traditionally weaned nursery pigs benefit from phase-feeding pharmacological concentrations of zinc oxide: effect on metallothionein and mineral concentrations. J Anim Sci. 1999;77:1199-207. https://doi.org/10.2527/1999.7751199x
  22. Nabuur MJ. Weaning piglets as a model for studying pathophysiology of diarrhea. Vet Quarterly. 1998;20(Suppl. 3):S42-5. https://doi.org/10.1080/01652176.1998.9694967
  23. Owusu-Asiedu A, Nyachoti CM, Marquardt RR. Response of early-weaned pigs to an enterotoxigenic Escherchia coli (K88) challenge when fed diets containing spray-dried porcine plasma or pea protein isolate plus egg yolk antibody, zinc oxide, fumaric acid, or antibiotic. J Anim Sci. 2003;81:1790-8.
  24. Liu P, Pieper R, Tedin L, Martin L, Meyer W, Rieger J, Plendl J, Vahjen W, Zentek J. Effect of dietary zinc oxide on jejunal morphological and immunological characteristics in weaned piglets. J Anim Sci. 2014;92:5009-18. https://doi.org/10.2527/jas.2013-6690
  25. Hedemann MS, Jensen BB, Poulsen HD. Influence of dietary zinc and copper on digestive enzyme activity and intestinal morphology in weaned pigs. J Anim Sci. 2006;84:3310-20. https://doi.org/10.2527/jas.2005-701
  26. Huang S, McFall M, Cegielski AC, Kirkwood RN. Effect of dietary zinc supplementation on Escherichia Coli septicemia in weaned pigs. Swine Health Prod. 1999;7:109-11.
  27. Broom LJ, Miller HM, Kerr KG, Knapp JS. Effects of zinc oxide and enterococcus faecium SF68 dietary supplementation on the performance, intestinal microbiota and immune status of weaned piglets. Res Vet Sci. 2006;80:45-54.

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