대한본초학회지 (The Korea Journal of Herbology)

  • 제32권6호
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  • Pages.23-29
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  • 2017
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
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고요산동물에서의 익지인의 요산저하 효과

Hyperuricemic effects of Alpiniae Oxyphyllae Fructus extracts

  • 이영실 (한국한의학연구원 한의약융합연구부) ;
  • 김지연 (한국한의학연구원 한의약융합연구부) ;
  • 김승형 (대전대학교 동서생명과학연구원) ;
  • 김동선 (한국한의학연구원 한의약융합연구부)
  • Lee, Young-Sil (KM Convergence Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Jiyoun (KM Convergence Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Seung-Hyung (Institute of Traditional Medicine and Bioscience, Daejeon University) ;
  • Kim, Dong-Seon (KM Convergence Research Division, Korea Institute of Oriental Medicine)
  • 투고 : 2017.10.14
  • 심사 : 2017.11.15
  • 발행 : 2017.11.30
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초록

Objective : Hyperuricemia is a metabolic disease characterized by elevated blood uric acid levels, and its prevalence is rapidly increasing worldwide. Alpiniae Oxyphyllae Fructus (AO) belonging to Zingiberaceae is one of well-known traditional medicines in China and Korea, and has been used to treat intestinal disorders, urosis, diuresis, and chronic glomerulonephritis traditionally. However, the effect of AO has not been studied. In this study we investigated the anti-hyperuricemic effect of AO, and the mechanisms underlying the effect in potassium oxonate (PO)-induced hyperuricemic rats. Methods : To examine the anti-hyperuricemic effects of the AO extract, serum uric acid levels were analyzed in normal and PO-induced hyperuricemic rats. The mechanism underlying the effects of the AO extract on uric acid levels was studied through xanthine oxidase (XOD) activity test and uric acid uptake assay in vitro. The chemical finger printing of the AO extract was analyzed using HPLC-DAD. Results : The AO extract significantly reduced serum uric acid levels in normal as well as PO-induced hyperuricemic rats. It also significantly inhibited the uptake of uric acid in oocytyes and human embryonic kidney cells (HEK293) expressing urate transporter (URAT)1, but not XOD activity in vitro. The chemical finger printing analysis of the AO extract showed nootkatone as a main component. Conclusion : The AO extract exhibits anti-hyperuricemic effects, and these effect were accompanied by increasing excretion of uric acid in kidney. Therefore, the AO extract could be used for prevention or treatment of hyperuicemia and gout.

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참고문헌

  1. Boffetta P, Nordenvall C. Nyren O, Ye W. A prospective study of gout and cancer. Eur J Cancer Prev. 2009 ; 18 : 127-132. https://doi.org/10.1097/CEJ.0b013e328313631a
  2. Huang J, Wang S, Zhu M, Chen J, Zhu X. Effects of genistein, apigenin, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice. Food Chem Toxicol. 2011 ; 49 : 1943-1947. https://doi.org/10.1016/j.fct.2011.04.029
  3. Dalbeth N, So A. Hyperuricaemia and gout: state of the art and future perspectives. Ann Rheum Dis. 2010 ; 69 : 1738-1743. https://doi.org/10.1136/ard.2010.136218
  4. Choi IA, Hong SJ. Updates in the management of gouty arthritis. The Korean Journal of Medicine: 2009; 76: 151-162.
  5. Alpinia oxyphylla Miq. Korean Traditional Knowledge Portal. Available from : URL : http://www.koreantk.com/ ktkp2014/medicine/medicine-view.view?medCd=M0 009449
  6. Kim JH, Kim YS, Lee SH, Choi G, Jeong SI, Ju YS. Chemical Components of herbal medicines in Ungok Herbolgy 2nd ed. Jeonju : Woosuk Press. 2016 : 236
  7. Park SY. The Relaxation Effects of Alpiniae Oxyphyllae Fructus on isolated Corpus Cavernosum smooth muscle. The Korea Journal of Herbology. 2015 ; 9: 71-79.
  8. Kim MS, Lee DC, Hong JE, Chang IS, Cho HY, Kwon YK, Kim HY. Antimicrobial effects of ethanol extracts from Korean and Indonesian plants. Korean J Food Sci Technol. 2000 ; 32 : 949-958
  9. Xie Y, Xiao M, Li D, Liu H, Yun F, Wei Y, Sang S, Du G. Anti-diabetic effect of Alpinia oxyphylla extract on 57BL/KsJ db-/db- mice. Exp Ther Med. 2017 ; 13 : 1321-1328. https://doi.org/10.3892/etm.2017.4152
  10. Ha H, Shim KS, Kim T, Lee CJ, Park JH, Kim HS, Ma JY. Water extract of the fruits of Alpinia oxyphylla inhibits osteoclast differentiation and bone loss. BMC Complement Altern Med. 2014 ; 14 : 352. https://doi.org/10.1186/1472-6882-14-352
  11. Ku BH, Illustrated book of Dongguibogam. Seoul : Minjung Publishing Co. 1993 : 232.
  12. Xie BB, Hou L, Guo BL, Huang WH, Yu JG. The compounds from n-butanol fraction of Alpinia oxyphylla. Yao Xue Xue Bao. 2014 ; 9 : 1569-1573.
  13. Noro T, ODA Y, Miyase T, Ueno A, Fukushima S. Inhibitors of xanthine oxidase from the flowers and buds of Daphne genkwa. Chem Pharm Bull. 1983 ; 31 : 3984-3987. https://doi.org/10.1248/cpb.31.3984
  14. Kang HJ, Song IS, Shin HJ, Kim WY, Lee CH, Shim JC, Zhou HH, Lee SS, Shin JG. Identification and functional characterization of genetic variants of human organic cation transporters in a Korean population. Drug Metab Dispos. 2007; 5 : 667-675.
  15. Becker MA, Jolly M. Hyperuricemia and associated diseases. Rheum Dis Clin North Am. 2006 ; 32 : 275-293. https://doi.org/10.1016/j.rdc.2006.02.005
  16. Kahn HA, Medalie JH, Neufeld HN, Riss E, Goldbourt U. The incidence of hypertension and associated factors: the Israel ischemic heart disease study. Am Heart J. 1972 ; 84 : 171-182. https://doi.org/10.1016/0002-8703(72)90331-6
  17. Ward HJ. Uric acid as an independent risk factor in the treatment of hypertension. Lancet 1998 ; 352 : 670-671. https://doi.org/10.1016/S0140-6736(05)60816-1
  18. Tomita M, Mizuno S, Yamanaka H, et al. Does hyperuricemia affect mortality? A prospective cohort study of Japanese male workers. J Epidemiol 2000 ; 10 : 403-409. https://doi.org/10.2188/jea.10.403
  19. So A, Thorens B, Uric acid transport and disease. J Clin Invest. 2010 ; 120 : 1791-1799. https://doi.org/10.1172/JCI42344
  20. Unno T, Sugimoto A, Kakuda T. Xanthine oxidase inhibitors from the leaves of Lagerstroemia speciosa (L.) Pers. J Ethnopharmacol. 2004 ; 93 : 391-395. https://doi.org/10.1016/j.jep.2004.04.012
  21. Ahn SO, Ohtomo S, Kiyokawa J, Nakagawa T, Yamane M, Lee KJ, Kim KH, Kim BH, Tanaka J, Kawabe Y, Horiba N. Stronger Uricosuric Effects of the Novel Selective URAT1 Inhibitor UR-1102 Lowered Plasma Urate in Tufted Capuchin Monkeys to a Greater Extent than Benzbromarone. J Pharmacol Exp Ther. 2016 ; 357 : 157-66. https://doi.org/10.1124/jpet.115.231647
  22. So A, Thorens B.Uric acid transport and disease. J Clin Invest. 2010 ; 120 : 1791-1799. https://doi.org/10.1172/JCI42344
  23. Wortmann RL. Gout and hyperuricemia. Curr Opin Rheumatol. 2002 ; 14 : 281-286. https://doi.org/10.1097/00002281-200205000-00015
  24. Choi HJ, Lee JH, Jung YS. (+)-Nootkatone inhibits tumor necrosis factor ${\alpha}$/interferon ${\gamma}$-induced production of chemokines in HaCaT cells. Biochem Biophys Res Commun. 2014 ; 447 : 278-284. https://doi.org/10.1016/j.bbrc.2014.03.121
  25. Tsoyi K, Jang HJ, Lee YS, Kim YM, Kim HJ, Seo HG, Lee JH, Kwak JH, Lee DU, Chang KC. (+)- Nootkatone and (+)-valencene from rhizomes of Cyperus rotundus increase survival rates in septic mice due to heme oxygenase-1 induction. J Ethnopharmacol. 2011 ; 137 : 1311-1317. https://doi.org/10.1016/j.jep.2011.07.062