Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
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Effect of Pine Inner Bark (Song-gi) Powder on Relief from Constipation in Loperamide-induced Rats

송기 분말이 Loperamide로 유도된 흰쥐의 변비 완화에 미치는 효과

  • Lee, Chang-Hyeon (National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Jang, Hyun-Wook (National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Kim, Young (National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Lee, Young-Eun (Dept. of Food and Nutrition, Wonkwang University)
  • 이창현 (농촌진흥청 국립농업과학원) ;
  • 장현욱 (농촌진흥청 국립농업과학원) ;
  • 김영 (농촌진흥청 국립농업과학원) ;
  • 이영은 (원광대학교 식품영양학과)
  • Received : 2017.07.10
  • Accepted : 2017.10.17
  • Published : 2017.10.31
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Abstract

This study investigated the effects of insoluble dietary fibers from pine (Pinus radiata D. Don) inner bark powder (PIBP) on loperamide constipation in rats. Male Sprague-Dawley rats were administered PIBP in their diets at concentrations of 5% and 10% for 4 weeks. Rats were divided in to four groups, normal diet group (Cont), a normal diet and loperamide group (Lop), 5% PIBP experimental diet and loperamide group (Lop+PIBP 5%), and 10% PIBP experimental diet and loperamide group (Lop+PIBP 10%). Constipation was induced by oral administration of loperamide (2 mg/kg, twice per day) for the last three days of the experiment. Food intake, body weight, properties of feces, gastrointestinal transit time, and serum lipid profiles were measured. When compared with the normal diet and loperamide group (Lop), there were increases in fecal pellet number (p<0.05), wet weight (p<0.001), and water content (p<0.001). Positive results were derived from relevant indicators to improve constipation. In addition, the number of fecal pellets in the colon was not significant, and decreased as PIBP content increased. PIBP had a concentration-dependent effect on reduction of total cholesterol, LDL-cholesterol, and triglycerides and elevation of HDL-cholesterol. These results indicate that PIBP may effectively prevent constipation.

Keywords

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