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A Case Report of Hematoma in the Lower Extremity Induced by Anti-platelet Agents (Astrix, Plavix)

항혈소판 응집 억제제(ASTRIX, PLAVIX) 복약 이후 하지 혈종 발생 사례 보고

  • Bae, Go-eun (Dept. of Internal Medicine, Pusan National University Korean Medicine Hospital) ;
  • Cho, Jae-hyun (Dept. of Internal Medicine, Pusan National University Korean Medicine Hospital) ;
  • Choi, Jin-yong (Dept. of Internal Medicine, Pusan National University Korean Medicine Hospital) ;
  • Shim, So-hyun (Dept. of Internal Medicine, Pusan National University Korean Medicine Hospital) ;
  • Seo, Hee-jeong (Dept. of Internal Medicine, Pusan National University Korean Medicine Hospital) ;
  • Hong, Jin-woo (Dept. of Internal Medicine, Pusan National University Korean Medicine Hospital) ;
  • Lee, In (Dept. of Internal Medicine, Pusan National University Korean Medicine Hospital) ;
  • Kim, So-yeon (Dept. of Internal Medicine, Pusan National University Korean Medicine Hospital) ;
  • Choi, Jun-young (Dept. of Internal Medicine, Pusan National University Korean Medicine Hospital) ;
  • Han, Chang-woo (Dept. of Internal Medicine, Pusan National University Korean Medicine Hospital) ;
  • Yun, Young-ju (Dept. of Internal Medicine, Pusan National University Korean Medicine Hospital) ;
  • Park, Seong-ha (Dept. of Internal Medicine, Pusan National University Korean Medicine Hospital) ;
  • Kwon, Jung-nam (Dept. of Internal Medicine, Pusan National University Korean Medicine Hospital)
  • 배고은 (부산대학교한방병원 한방내과) ;
  • 조재현 (부산대학교한방병원 한방내과) ;
  • 최진용 (부산대학교한방병원 한방내과) ;
  • 심소현 (부산대학교한방병원 한방내과) ;
  • 서희정 (부산대학교한방병원 한방내과) ;
  • 홍진우 (부산대학교한방병원 한방내과) ;
  • 이인 (부산대학교한방병원 한방내과) ;
  • 김소연 (부산대학교한방병원 한방내과) ;
  • 최준용 (부산대학교한방병원 한방내과) ;
  • 한창우 (부산대학교한방병원 한방내과) ;
  • 윤영주 (부산대학교한방병원 한방내과) ;
  • 박성하 (부산대학교한방병원 한방내과) ;
  • 권정남 (부산대학교한방병원 한방내과)
  • Received : 2017.09.08
  • Accepted : 2017.10.27
  • Published : 2017.10.30

Abstract

Objective: Our aim was to report a case of hematoma in the lower extremity induced by anti-platelet agents (Astrix, Plavix). Methods: The patient was prescribed anti-platelet agents and a hematoma occurred three times in the lower extremity. Before admission, the hematoma had occurred in the lateral compartment area of left lower extremity ($2{\times}2cm$). We detected a spontaneous hematoma in the lateral compartment area of right lower extremity ($8{\times}4cm$) and we stopped the Astrix medication. We also used herbal medicine (大黃左經湯加味方 (Daehwangjwagyeong-tang-gami)), external therapy of 大黃梔子 (Dae-hwang-Chi-ja) powder, and wet cupping therapy. We then detected a spontaneous hematoma in the posterior compartment area of the left lower extremity ($5{\times}5cm$) and we stopped the Plavix medication. We also used herbal medicine and external therapy. Results: After cessation of the anti-platelet agents (Astrix, Plavix), no recurrence of hematoma was observed in lower extremity and there was no recurrence of cerebral infarction. Conclusions: When anti-platelet agents are administered, attention should be paid to the patient's age and adverse events of the drugs. Bleeding symptoms and adverse effects should be continuously monitored.

Keywords

References

  1. Kim JD, Kwon JN, Kim YG, Kim JW, Sa Eh, Min SS, et al. Clinical Study of Korean Medical Treatment and Korean-Western Medical Treatment on Acute Ischemic Stroke Patients. Korean J Oriental Physiology & Pathology 2007;21(2):543-7.
  2. Kim JH, Sin WJ, Jang JW, Kim JY, Min SS, Hwang WD. A Clinical Study of Combined Eastern and Western Treatment of Acute Stage Stroke. Korean J Oriental Int Med 2004;25(4):65-74.
  3. Lee YH. A Study on the Use of Oriental-Western Integrated Medical Service and Patient Satisfaction. Chung-Ang University 2010.
  4. Park JK, Yoo JS, Koh KW, Kim CB, Choi SY. The Combined Treatment with Oriental Herbal Medicine and Western Biomedical Medicine among Cerebrovascular Attack Patients. J Korean Oriental Med 2006;27(1):1-10.
  5. Park SJ, Kwon YK, Shin JG. Current Status of Herb-Drug Interaction Information and Information Database in Korea. Korean J Oriental Physiology & Pathology 2010;24(4):543-52.
  6. Cho HJ, Kang TH. Pharmacological Secondary Prevention of Ischemic Stroke. Brain and Neuro Rehabilitation 2014;7(2):76-85.
  7. Cho SJ. Factors to be Considered for a Choice of Antiplatelet Agents. J Korean Acad Fam Med 2006;27(1):1-6.
  8. Cakar MA, Kocayigit I, Aydin E, Demirci H, Gunduz H. Clopidogrel-induced spontaneous pectoral hematoma. Indian journal of pharmacology 2012;44(4):526-7. https://doi.org/10.4103/0253-7613.99342
  9. Sung JH, Hong JT, Son BC, Lee SW. Clopidogrelinduced spontaneous spinal epidural hematoma. J Korean Med Sci 2007;22(3):577-9. https://doi.org/10.3346/jkms.2007.22.3.577
  10. Jung IM, Yu DS, Park MJ, Yeom SR, Kwon YD. A Clinical Case of Oriental Medical Treatments for Traumatic Thigh Subcutaneous Hematoma by Traffic Accident. J Oriental Rehab Med 2010;20(2):219-25.
  11. Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ (Clinical research ed). 2002;324(7329):71-86. https://doi.org/10.1136/bmj.324.7329.71
  12. Cheon SM, Yun GU, Park KW, Kin SH, Kim HW, Shun HC, et al. The Difference of Platelet Aggregability in Patients with Cerebral Infarction accordigng to Type of Anti-platelet Agents. J Korean Neurol Assoc 2004;22(1):11-5.
  13. Jeon SM, Cha JK, Kim SH, Kim JW. Clopidogrel Resistance in Acute Ischemic Stroke. J Korean Neurol Assoc 2006;24(4):318-22.
  14. Kim CW. Hypersensitivity to Aspirin and Nonsteroidal Anti-inflammatory Drugs. Korean J Med 2014;87(6):659-64. https://doi.org/10.3904/kjm.2014.87.6.659
  15. Jung WJ, Kim YJ, Park YH, Cho JH, Kim GC. A Case of Deep Vein Thrombosis Following Cellulitis of the Lower Leg. Korean J Med 2014;86(3):334-8. https://doi.org/10.3904/kjm.2014.86.3.334
  16. Heo J. Donguibogam. Hadong: Donguibogam Publisher; 2010, p. 787-8.
  17. Society KAM. The Acupuncture and Moxibustion. Seoul: Jipmoondang; 1998. p. 1066, 243.
  18. Lee GJ, Lee YH. Dong Ssi Chim Gu Bang Hyeol Yo Beop(Dong Ssi Acupuncture and Venesection Therapy). Dae Buk: Won Ji Seo Guk; 1994, p. 4-14.
  19. Kim SJ, Park JS, Yee JJ, Park OJ, Kim SG, Jeong HH, et al. The Effect of Venesection with Cupping Therapy at Jeonjung(CV17) on the Heart Rate Variability in Healthy Adults. The Acupuncture 2013;30(4):15-24. https://doi.org/10.13045/acupunct.2013018
  20. Lee SH. The Effect of Wet Cupping Therapy on the temperature change of body surfaces with Low Back Pain. Daejeon University 2007.
  21. Kim GI, Kim YS, Yang JK, Koo HS, Kim SM, Lee TH, et al. Spontaneous Intramural Hematoma of the Sigmoid Colon Caused by Anti-platelet Agents. Clinical Endoscopy 2011;42(6):397-400.