Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Flail arm syndrome with several issues related to the diagnostic process

  • Kim, Jae-Youn (Department of Neurology, Konyang University of College of Medicine) ;
  • Park, Yun Kyung (Department of Neurology, Konyang University of College of Medicine) ;
  • Yoon, Bora (Department of Neurology, Konyang University of College of Medicine) ;
  • Lee, Kee Ook (Department of Neurology, Konyang University of College of Medicine) ;
  • Kim, Yong-Duk (Department of Neurology, Konyang University of College of Medicine) ;
  • Na, Sang-Jun (Department of Neurology, Konyang University of College of Medicine)
  • Received : 2016.09.02
  • Accepted : 2017.01.02
  • Published : 2017.01.31
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Abstract

Flail arm syndrome (FAS), known as one of the atypical amyotrophic lateral sclerosis (ALS) variants, has a similar clinical course and pathologic findings as ALS. Therefore it is difficult to differentiate between ALS and FAS at a glance. There are few reports involving individual analysis of FAS patients to date. The findings of polysomnography (PSG) in patient with FAS are not well known. We report a male FAS patient with review of literatures and several issues related to the diagnostic process.

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References

  1. Wijesekera LC, Mathers S, Talman P, Galtrey C, Parkinson MH, Ganesalingam J, et al. Natural history and clinical features of the flail arm and flail leg ALS variants. Neurology 2009;72:1087-1094. https://doi.org/10.1212/01.wnl.0000345041.83406.a2
  2. Hino S, Sasaki S. Flail arm syndrome with cytoplasmic vacuoles in remaining anterior horn motor neurons: a peculiar variant of amyotrophic lateral sclerosis. Neuropathology 2015;35:582-586. https://doi.org/10.1111/neup.12223
  3. Hubers A, Hildebrandt V, Petri S, Kollewe K, Hermann A, Storch A, et al. Clinical features and differential diagnosis of flail arm syndrome. J Neurol 2016;263:390-395. https://doi.org/10.1007/s00415-015-7993-z
  4. Yoon BN, Choi SH, Rha JH, Kang SY, Lee KW, Sung JJ. Comparison between flail arm syndrome and upper limb onset amyotrophic lateral sclerosis: clinical features and electromyographic findings. Exp Neurobiol 2014;23:253-257. https://doi.org/10.5607/en.2014.23.3.253
  5. Avidan AY, Malhotra R. Sleep in Other neurologic disorders. In: Kryger MH, Avidan AY, Berry RB, eds. Atlas of Clinical sleep medicine. 2nd ed. Philadelphia: Elsevier Saunders, 2014;230.
  6. Hutchinson D, Whyte K. Neuromuscular disease and respiratory failure. Pract Neurol 2008;8:229-237. https://doi.org/10.1136/pn.2008.152611
  7. Quaranta VN, Carratu P, Damiani MF, Dragonieri S, Capozzolo A, Cassano A, et al. The prognostic role of obstructive sleep apnea at the onset of amyotrophic lateral sclerosis. Neurodegener Dis 2017;17:14-21. https://doi.org/10.1159/000447560
  8. Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol 2013;177:1006-1014. https://doi.org/10.1093/aje/kws342
  9. Tandan R. Disorders of the Upper and Lower Motor Neurons. In: Bradley WG, Daroff RB, Fenichel GM, Marsden CD, eds. Neurology in Clinical Practice : Principles of Diagnosis and Management. 2nd ed. Vol. 2. Boston: Butterworth-Heinemann, 1996;1844.
  10. Kumar S, Mehta VK, Shukla R. Owl's eye sign: A rare neuroimaging finding in flail arm syndrome. Neurology 2015;84;1500. https://doi.org/10.1212/WNL.0000000000001449
  11. Kollewe K, Wurster U, Sinzenich T, Korner S, Dengler R, Mohammadi B, et al. Anti-ganglioside antibodies in amyotrophic lateral sclerosis revisited. PLoS One 2015;10:e0125339. https://doi.org/10.1371/journal.pone.0125339