Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Distal acquired demyelinating symmetric neuropathy associated with anti-GM1 and anti-GD1b antibodies

  • Ko, Keun Hyuk (Department of Neurology, Jeju National University School of Medicine) ;
  • Jwa, Seung-Joo (Department of Neurology, Jeju National University School of Medicine) ;
  • Park, Sung Joo (Department of Neurology, Jeju National University School of Medicine) ;
  • Kang, Sa-Yoon (Department of Neurology, Jeju National University School of Medicine)
  • Received : 2016.04.21
  • Accepted : 2016.07.25
  • Published : 2017.01.31
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Abstract

Distal acquired demyelinating symmetric (DADS) neuropathy is a variant form of chronic inflammatory demyelinating polyradiculoneuropathy. A 54-year-old man presented with gait disturbance owing to weakness in both legs. Nerve conduction studies showed demyelinating sensorimotor polyneuropathy, and laboratory studies demonstrated anti-GM1 and anti-GD1b IgG antibodies, but no anti-myelin associated glycoprotein activity. We suggest that an antiganglioside antibodies assay needs to be applied when DADS neuropathy is suspected in order to improve the classification of dysimmune neuropathies.

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References

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