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Computed Tomographic Findings of Adenocarcinoma of the Esophagocardia Region in a Pekingese Dog with Brachycephalic Syndrome

  • Cho, Yugyeong (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Chungnam National University) ;
  • Nam, Yunjeong (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Chungnam National University) ;
  • Chae, Sooyoung (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Chungnam National University) ;
  • Jeong, Youjin (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Chungnam National University) ;
  • Song, Youngmok (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Soyoung (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Chungnam National University) ;
  • Choi, Hojung (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Chungnam National University) ;
  • Lee, Youngwon (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Chungnam National University)
  • Received : 2017.07.27
  • Accepted : 2017.08.11
  • Published : 2017.08.31

Abstract

A 6-year-old female Pekingese dog, weighing 3.85 kg was presented with regurgitation, ptyalism, weight loss and anorexia. The dog was cachexic and severely dehydrated. Physical examination of the dog confirmed upper respiratory noise, which was classified as a stridor most apparent on inspiration, respiratory effort with stenotic nares. Upper respiratory signs were thought to be caused by brachycephalic syndrome. On the lateral thoracic radiograph, the caudal one third of the esophagus was visible as a soft tissue band. CT revealed oval-shaped, soft tissue attenuating mass in size of $2.3{\times}1.0{\times}1.1cm$ arising from caudal one third of the esophagus. The mass was protruding from esophageal wall to lumen and irregular margined with heterogenous contrast enhancement. The wall of cardia and fundus was focally thickened. Gastric lymph node was enlarged with contrast enhancing. On histopathologic examination, esophageal mass was confirmed as papillary adenocarcinoma, and the gastric sample showed the same result. In human, adenocarcinoma commonly occur in esophagus and cardia, but it has not been commonly reported in veterinary medicine. This report described computed tomographic features of adenocarcinoma of the esophagocardia region in a Pekingese dog with brachycephalic syndrome.

Keywords

References

  1. Buskens CJ, Hulscher JBF, van Gulik TM, Fiebo J, van Lanschot JJB. Histopathologic evaluation of an animal model for Barrett's esophagus and adenocarcinoma of the distal esophagus. J Surg Res 2006; 135: 337-344. https://doi.org/10.1016/j.jss.2006.04.023
  2. Dobson JM, Lascelles BDX. BSAVA manual of canine and feline oncology, 3rd Ed. British Small Animal Veterinary Association. 2011: 206-211
  3. Falk GW. Risk factors for esophageal cancer development. Surg oncol clin N Am 2009; 18: 469-485. https://doi.org/10.1016/j.soc.2009.03.005
  4. Gibson CJ, Parry NMA, Jakowski RM, Cooper J. Adenomatous polyp with intestinal metaplasia of the esophagus (Barrett esophagus) in a dog. Vet Path 2010; 47: 116-119. https://doi.org/10.1177/0300985809352973
  5. Gualtieri M, Monzeglio MG, Scanziani E. Canine gastric adenocarcinoma. Vet Clin North Am Small Anim Pract 1999; 29: 415-40. https://doi.org/10.1016/S0195-5616(99)50029-6
  6. Haggitt RC, Tryzelaar J, Ellis FH, Colcher H. Adenocarcinoma complicating columnar epithelium-lined (Barrett's) esophagus. Am J Clin Pathol 1978; 70: 1-5. https://doi.org/10.1093/ajcp/70.1.1
  7. Hong SJ, Kim TJ, Nam KB, Lee IS, Yang HC, Cho S, Lee KW. New TNM staging system for esophageal cancer: what chest radiologists need to know. Radiographics 2014; 34: 1722-1740. https://doi.org/10.1148/rg.346130079
  8. Kim JJ. Upper gastrointestinal cancer and reflux disease. J Gastric Cancer 2013; 13: 79-85. https://doi.org/10.5230/jgc.2013.13.2.79
  9. Lecoindre P, Richard S. Digestive disorders associated with the chronic obstructive respiratory syndrome of brachycephalic dogs: 30 cases (1999-2001). Revue Med Vet (Toulouse) 2004; 155: 141-146.
  10. Li H, Walsh TN, O'Dowd G, Gillen, P, Byrne PJ, Hennessy TP. Mechanisms of columnar metaplasia and squamous regeneration in experimental Barrett's esophagus. Surgery 1994; 115: 176-181.
  11. Macdonald WC, Macdonald JB. Adenocarcinoma of the esophagus and/or gastric cardia. Cancer 1987; 60: 1094-1098. https://doi.org/10.1002/1097-0142(19870901)60:5<1094::AID-CNCR2820600529>3.0.CO;2-4
  12. Miwa K, Oyama K, Fujimura T. A COX-2 inhibitor suppresses esophageal inflammation-metaplasia-adenocarcinoma sequence in rats. Nihon rinsho. Nihon Rinsho 2005; 63: 1387-1393.
  13. Okanishi H, Shibuya H, Miyasaka T, Asano K, Sato T, Watari T. Adenosquamous carcinoma of the oesophagus in a dog. J Small Anim Pract 2015; 56: 521-523. https://doi.org/10.1111/jsap.12333
  14. Poncet CM, Dupre GP, Freiche VG, Estrada MM, Poubanne YA, Bouvy BM. Prevalence of gastrointestinal tract lesions in 73 brachycephalic dogs with upper respiratory syndrome. J Small Anim Pract 2005; 46: 273-279. https://doi.org/10.1111/j.1748-5827.2005.tb00320.x
  15. Randolph JF, Center SA, Flanders JA, Diters RW. Hypertrophic osteopathy associated with adenocarcinoma of the esophageal glands in a dog. J Am Vet Med Assoc 1984; 184: 98-99.
  16. Takiguchi M, Yasuda J, Hashimoto A, Ochiai K, takura C. Esophageal/gastric adenocarcinoma in a dog. J Am Anim Hosp Assoc 1996; 33: 42-44.
  17. Tams TR, Rawlings CA. Small animal endoscopy, 3rd Ed. Elsevier Health Sciences 2010; 90-93.
  18. Withrow SJ, Page R, Vail DM. Withrow and MacEwen's small animal clinical oncology, 5th Ed. Elsevier Health Sciences 2013; 399-400, 402-404.