Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Characteristics of PU/PEG Hybrid Scaffolds Prepared by Electrospinning

전기방사법으로 제조한 PU/PEG 복합 지지체의 특성

  • Seol, Bokyung (Department of Biomedical Engineering, Daelim University) ;
  • Shin, Ji-Yeon (Department of Biomedical Engineering, Daelim University) ;
  • Oh, Gayeon (Department of Biomedical Engineering, Daelim University) ;
  • Lee, Deuk Yong (Department of Biomedical Engineering, Daelim University) ;
  • Lee, Myung-Hyun (Energy and Environmental Division, Korea Institute of Ceramic Engineering and Technology)
  • 설보경 (대림대학교 의공융합과) ;
  • 신지연 (대림대학교 의공융합과) ;
  • 오가연 (대림대학교 의공융합과) ;
  • 이득용 (대림대학교 의공융합과) ;
  • 이명현 (에너지환경소재, 세라믹기술원)
  • Received : 2017.07.05
  • Accepted : 2017.10.21
  • Published : 2017.10.31
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Abstract

Polyurethane/polyethylene glycol(PU/PEG) hybrid scaffolds with various concentrations of PEG (0 to 50wt%) were prepared by electrospinning to evaluate the mechanical properties and the biocompatibility of the PU/PEG blend scaffolds. The 12wt% PU/PEG polymers were studied due to the absence of beads. The ultimate tensile strength of 12wt% PU was $8.2{\pm}0.5MPa$. The strength increased to $9.2{\pm}0.7MPa$ when 10% PEG was added to PU. However, the dry and the wet strength of PU/PEG scaffolds began to decrease dramatically when the PEG content was more than 10wt%. No cytotoxicity was observed for all the PU/PEG scaffolds investigated, indicating that the PU/PEG hybrid scaffolds are clinically safe and effective to small-diameter vascular grafts. In addition, the L-929 cells attached and proliferated well on the PU/PEG hybrid scaffolds.

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References

  1. H. Wang, Y. Feng, Z. Fang, W. Yuan, and M. Khan, "Coelectrospun blends of PU and PEG as potential biocompatible scaffolds for small-diameter vascular tissue engineering," Mater. Sci. Eng. C, vol. 32, pp. 2306-2315, 2012. https://doi.org/10.1016/j.msec.2012.07.001
  2. J. Hu, X. Sun, H. Ma, C. Xie, Y.E. Chen, P.X. Ma, "Porous nanofibrous PLLA scaffolds for vascular tissue engineering," Biomater., vol. 31, pp. 7971-, 2010. https://doi.org/10.1016/j.biomaterials.2010.07.028
  3. Y. Kim, S. Son, C. Chun, J. Kim, D.Y. Lee, H.J. Choi, and T. Kim, "Effect of PEG addition on pore morphology and biocompatibility of PLLA scaffolds prepared by freeze drying," Biomed. Eng. Lett., vol. 6, pp. 287-295, 2016. https://doi.org/10.1007/s13534-016-0241-3
  4. S. Song, J. Choi, H. Cho, D. Kang, D.Y. Lee, J. Kim, and J. Jang, "Synthesis and characterization of porous poly(${\varepsilon}$-caprolactone)/ silica nanocomposites," Polym. Kor., vol. 39, pp. 323-328, 2015. https://doi.org/10.7317/pk.2015.39.2.323
  5. D.I. Cha, K.W. Kim, G.H. Chu, H.Y. Kim, K.H. Lee, and N. Bhattarai, "Mechanical behaviors and characterization of electrospun polysulfone/polyurethane blend nonwovens," Macromol. Res., vol. 14, pp. 331-337, 2006. https://doi.org/10.1007/BF03219090
  6. K. Lee, B. Lee, C. Kim, H. Kim, K. Kim, and C. Nah, "Stressstrain behavior of the electrospun thermoplastic polyurethane elastomer fiber mats," Macromol. Res., vol. 13, pp. 441-445, 2005. https://doi.org/10.1007/BF03218478
  7. A. Arinstein, M. Burman, O. Gendelman, and E. Zussman, Effect of supramolecular structure on polymer nanofiber elasticity, Nature Nanotechnol., vol. 2, pp. 59-62, 2007. https://doi.org/10.1038/nnano.2006.172
  8. L. Persano, C. Dagdeviren, Y. Su, Y. Zhang, S. Girardo, D. Pisignano, Y. Huang, and J.A. Rogers, "Higher performance piezoelectric devices based on aligned arrays of nanofibers of poly(vinlidenefluoride-co-trifluoroethylene)," Nature Comm., vol. 4, pp. 1633, 2013. https://doi.org/10.1038/ncomms2639
  9. M. Richard-Lacroix and C. Pellerin, "Molecular orientation in electrospun fibers: from mats to single fibers," Macromol., vol. 46, pp. 9473-9493, 2013. https://doi.org/10.1021/ma401681m
  10. M.D. Edwards, G.R. Mitchell, S.D. Mohan, and R.H. Olley, Development of orientation during electrospinning of fibres of poly(${\varepsilon}$-caprolactone), Euro. Polym. J., vol. 46, pp. 1175-1183, 2010. https://doi.org/10.1016/j.eurpolymj.2010.03.017
  11. Y. Song, S. Son, D.Y. Lee, M. Lee, and B. Kim, Photocatalytic activity of $TiO_2$ nanomaterials, J. Ceram. Proc. Res., vol. 17, pp. 1197-1201, 2016.
  12. C. Cheon, Y. Kim, S. Son, D.Y. Lee, J. Kim, M. Kwon, Y. Kim, and S. Kim, Viscoelasticity of hyaluronic acid dermal fillers prepared by crosslinked HA microspheres, Polym. Kor., vol. 40, pp. 600-606, 2016. https://doi.org/10.7317/pk.2016.40.4.600
  13. C. Chun, D.Y. Lee, J. Kim, M. Kwon, Y. Kim, and S. Kim, "Effect of molecular weight of hyaluronic acid on viscoelastic and particle texturing feel properties of HA dermal biphasic fillers," Biomater. Res., vol. 20, pp. 275-281, 2016.
  14. M.M. Hohman, M. Shin, G. Rutledge, and M.P. Brenner, "Electrospinning and electrically forced jets. I. Stability theory," Phys. Fluids, vol. 13, pp. 2201-2220, 2001. https://doi.org/10.1063/1.1383791
  15. M.M. Hohman, M. Shin, G. Rutledge, and M.P. Brenner, "Electrospinning and electrically forced jets. II. Applications," Phys. Fluids, vol. 13, pp. 2221-2236, 2001. https://doi.org/10.1063/1.1384013