Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
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Rehmanniae Radix, an Effective Treatment for Patients with Various Inflammatory and Metabolic Diseases: Results from a Review of Korean Publications

  • Kim, Seok-hee (Department of Health Service, Imsil-Gun Bogun Hospital) ;
  • Yook, Tae-han (Department of Acupuncture & Moxibustion Medicine, Woosuk University Hospital of Korean Medicine) ;
  • Kim, Jong-uk (Department of Acupuncture & Moxibustion Medicine, Woosuk University Hospital of Korean Medicine)
  • Received : 2017.04.25
  • Accepted : 2017.05.22
  • Published : 2017.06.30
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Abstract

Objectives: This study was a review of the literature published on the efficacy of Rehmanniae Radix to obtain information to provide both a foundation for its clinical use and directions for future studies. Methods: This study selected 30 publications registered to databases or published in Korea by March 13, 2017, by searching electronic journal databases, i.e., NDSL, OASIS, RISS, and KISS, in order to review the efficacy of Rehmanniae Radix. The search was conducted using the keywords '生地黃', '鮮地黃', 'Rehmannia Glutinosa', and 'Rehmanniae Radix', and the search results were compiled and analyzed. Results: The selected publications included antioxidant effects (12 publications), data involving blood glucose reduction (4 publications), effects on the autonomic nervous system (3 publications), and effects on the human body (11 publications). Conclusion:The results of this literature review indicate that Rehmanniae Radix is effective in treating patients with various inflammatory and metabolic diseases, such as high blood pressure and diabetes. Based on these results, we believe that Rehmanniae Radix can be used effectively to treat patients with such diseases.

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References

  1. Yook CS. [Herbal medicine II]. Seoul: Gwangmyunguihagsa Publishers; 1992. 141 p. Korean.
  2. Shin MK. [Clinical herb]. Seoul: Namsandang Publishers; 1986. 218 p. Korean.
  3. Lee SI. [Clinical application of Korean medicine]. Seoul: Sungbosa Publishers; 1986. p. 199-201. Korean.
  4. Shin JY. [Bangyag-Habpyeon commentary]. Seoul: Sungbosa Publishers; 2008. 152 p. Korean.
  5. Seo HS. [The experimental study on anti-inflammation and anti-oxidation of indigo naturalis and Rehmanniae Radix]. J Korean Orient Med Ophthalmol Otolaryngol Dermato. 2008;21(3):104-10.
  6. Chae BS, Yang JH. Regulatory effect of fresh rehmanniae radix extract on the in vitro production of proinflammatory cytokines in pristane-induced lupus mice. Nat Prod Sci. 2007;13(4):322-7.
  7. Kang KH, Kim CH. [Inhibitory effect of rehmannia glutinosa pharmacopuncture solution on $\beta$-hexosaminidase release and cytokine production via $Fc{\varepsilon}RI$ signaling in RBL-2H3 cells]. J Pharmacopuncture. 2011;14(2):15-24. Korean. https://doi.org/10.3831/KPI.2011.14.2.015
  8. Shin KS, Son JS, Kim DE, Jeon WJ, Jeong SH, Shin GJ, et al. [The effect of rhemanniae radix extract on allergic contact dermatitis on mice induced by DNCB]. Korean J Orientaln Medical Prescription. 2000;8(1):257-79.
  9. Jo YJ. [Charactrization of biological activities of rehmannia glutinosa extracts]. J Life Sci. 2012;22(7):943-9. Korean. https://doi.org/10.5352/JLS.2012.22.7.943
  10. Lee YH, Kim JW, Chae SK, Ahn JH, Do GY, Koo DB. Anti-apoptotic effects of catalpol on preimplantaion porcine embryos. J Emb Trans. 2015;30(1):23-31. https://doi.org/10.12750/JET.2015.30.1.23
  11. Jin CH, Lee YM, Kang MA, Park YD, Choi DS, Byun MW, et al. Anti-inflammatory activities of ethylacetate extract of rehmannia glutinosa in LPS-264.7 cells. Food Sci. Biotechnol. 2009;18(4):923-7.
  12. Moon YR, Lim JH, Park MR, Yu CY, Chung IM, Yang DC, et al. Antioxidant enzyme responses against abiotic and biotic stresses in Rehmanniae Radix and Glycine max L. Korean J Med Crop Sci. 2004;12(5):360-5.
  13. Lim JD, Kim HY, Kim MJ, Yang DC, Yun SJ, Chung IM, et al. Biological activities of resveratrol-3-O-$\ss$-D-giucoside in transgenic Rehmanniae Radix. J Plant Biotechnol. 2005;5(1):129.
  14. Kang KH, Lee KH, Yoon HM, Jang KJ, Song CH, Kim CH. Rehmannia glutinosa pharmacopuncture solution regulates functional activation, $Fc{\varepsilon}RI$ expression, and signaling events in mast cells. J Pharmacopuncture. 2012;15(4):32-41. https://doi.org/10.3831/KPI.2012.15.015
  15. Chae BS, Shin TY. Effect of fresh rehmanniae radix methanol extracts on the production of cytokines. J Pharm Soc Korea. 2006;50(3):184-90.
  16. Kim SB, Kim KJ. [The effects of rehmannia glutinosa on the protein expression related to the angiogenesis, cell survival and inflammation]. J Korean Orient Med Ophthalmol Otolaryngol Dermato. 2006;19(3):22-33. Korean.
  17. Kim HJ, Yoon IS, Kim YC. [Antidiabetic, antioxidative and renoprotective effects of rehmanniae radix preparata extract in streptozotocin-induced diabetic rats]. Biomed Sci Lett. 2008;14(1):19-26. Korean.
  18. Kim JS, Na CS. [Effect of rehmanniae radix and pear phenolic compound on the STZ-treated mice for induction of diabetes]. J Korean Soc Food Sci Nutr. 2004;33(1):66-71. Korean. https://doi.org/10.3746/jkfn.2004.33.1.066
  19. Kim JS. [Effect of rhemanniae radix on the hyperglycemic mice induced with streptozotocin]. J Korean Soc Food Sci Nutr. 2004;33(7):1133-8. Korean. https://doi.org/10.3746/jkfn.2004.33.7.1133
  20. Jeong HJ, Kim IH. [The effects of rehmanniae radices extracts on streptozotocin-induced hyperglycemia in rats]. J Research Institute of Pharmacy. 1990;4(1):22-31. Korean.
  21. Yook TH, Yu JS, Lee HY, Song BY, Kim LH, Roh JD, et al. Comparing the effects of distilled rehmannia glutinosa, wild ginseng and astragali radix pharmacopuncture with heart rate variability (HRV) : a randomized, shamcontrolled and double-blind clinical trial. J Acupunct Meridian Stud. 2009;2(3):239-47. https://doi.org/10.1016/S2005-2901(09)60061-3
  22. Shin JC, Kim LH, Song BY, Yook TH. [The effects of distilled rehmannia glutinosa herbal acupuncture on the heart rate variability(HRV)]. J Pharmacopuncture. 2008;11(1):83-97. Korean. https://doi.org/10.3831/KPI.2008.11.1.083
  23. Lee HY, You JS, Yook TH, Hong GE. [The effects of distilled Astragali Radix herbal acupuncture, wild ginseng herbal acupuncture and Rehmannia Glutinosa herbal acupuncture on vital sign; a randomized, placebo-controlled, double-blind clinical trial]. The Acupuncture. 2007;24(5):207-17. Korean.
  24. Lee B, Shim I, Lee H, Hahm DH. Rehmannia glutinosa ameliorates scopolamine-induced learning and memory impairment in rats. J Microbiol Biotechnol. 2011;21(8):874-83. https://doi.org/10.4014/jmb.1104.04012
  25. Park JB, Lee TH. [Effects of Rehmanniae Radix on HPA axis system and catecholamienrgic system in FST]. Herbal Formula Science. 2010;18(1):133-44. Korean.
  26. Heo JW, Yook TH. [The study on the composition of Rehmanniae Radix extracts by supercritical carbon dioxide extraction and by hydrodistillation extraction]. The Acupuncture. 2011;28(2):89-95. Korean.
  27. Shin MS, Son YJ, Lee YJ. The effects of Rehmanniae Radix on the propulsive peristalsis of the rat's gastrointestine]. Kor J Herbol. 2001;16(1):189-99. Korean.
  28. Kim JY, Jo OH, Choi CM, Jo HB. [Rhizoma Rehmanniae induced apoptosis in human cervical carcinoma HeLa cells]. J Orient Obstet Gynecol. 2006;19(1):69-80. Korean.
  29. Park JB, Kim KS. [Effects of Rehmannia glutinosa aqua - acupuncture at the meridian ponits BL23 on the renal function in two-kidney one clip goldblatt hypertensive rats]. The Acupuncture. 1994;11(1):225-39. Korean.
  30. Lee GH, Kang SS, An WG, Lee YS, Kwon YK, Shin SW. [Comparison of immune promotion effects of water-extracted Angelicae gigantis, Rehmanniae Radix, Paeoniae japonica and Polygoni multiflori Radix]. JPPKM. 2006;20(6):1507-15. Korean.
  31. Kwon YD, Song YS. [Effects of Rhizoma rehmanniae adminstration on the innate and adap tive responses in the mouse]. JORM. 1998;8(1):233-54. Korean.
  32. Kim JU, Choi HY, Jo JH, An DG, Yook CS, Byeon MW, et al. [Studies on the stability of catapol components, and genotoxic safety of $\gamma$-irradiated Rehmanniae Radix crude]. Nat Prod Sci. 2005;36(2):75-80.
  33. Ki YS, Son YJ, Lee YJ. [Effects of Rehmanniae Radix on the rat liver damaged with CCl4]. Kor J Herbol. 2000;15(1):45-51. Korean.
  34. Kwon NW, Song BG, Koo BH. [An experimental study on the effect of Rehmannise Radix and cirsii herba extract administration to the serum prothrombin time in mouse]. J East-West Medical Research Ins. 1982;5(1):259-68. Korean.
  35. Go SG, Lim GH. [Discussion of ginseng properties through a historical research of Korean ginseng]. Kor J Herbol. 2009;24(3):169-72. Korean.
  36. Nam GY. [Clinical applications and efficacy of Korean ginseng]. J Ginseng Res. 2002;26(3):111-31. Korean. https://doi.org/10.5142/JGR.2002.26.3.111
  37. Yun U, Heo SI, Wang MH, Jeong MJ. [Antioxidant and antidiabetic effects of various sections of astragalus membranaceus]. Kor J Pharmacogn. 2009;40(1):1-5. Korean.
  38. Shin HS, Go BH, Lee EJ. [The origin, changes and compositive principles of Baekhaoleejung-tang]. J Sasang Constitut Med. 2011;23(2):164-73.