Radiation Oncology Journal

  • 제35권3호
  • /
  • Pages.268-273
  • /
  • 2017
  • /
  • 2234-1900(pISSN)
  • /
  • 2234-3156(eISSN)
대한방사선종양학회 (The Korean Society for Radiation Oncology)
권호 표지
DOI QR코드

DOI QR Code

Role of fractionated radiotherapy in patients with hemangioma of the cavernous sinus

  • Park, Sunmin (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Yoon, Sang Min (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Sumin (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Park, Jin-hong (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Song, Si Yeol (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Sang-wook (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ahn, Seung Do (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Jong Hoon (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Choi, Eun Kyung (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine)
  • 투고 : 2017.04.17
  • 심사 : 2017.07.10
  • 발행 : 2017.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: We performed this retrospective study to investigate the outcomes of patients with hemangioma of the cavernous sinus after fractionated radiotherapy. Materials and Methods: We analyzed 10 patients with hemangioma of the cavernous sinus who were treated with conventional radiotherapy between January 2000 and December 2016. The median patient age was 54 years (range, 31-65 years), and 8 patients (80.0%) were female. The mean hemangioma volume was $34.1cm^3$ (range, $6.8-83.2cm^3$), and fractionated radiation was administered to a total dose of 50-54 Gy with a daily dose of 2 Gy. Results: The median follow-up period was 6.8 years (range, 2.2-8.8 years). At last follow-up, the volume of the tumor had decreased in all patients. The average tumor volume reduction rate from the initial volume was 72.9% (range, 18.9-95.3%). All 10 of the cranial neuropathies observed before radiation therapy had improved, with complete symptomatic remission in 9 cases (90%) and partial remission in 1 case (10%). No new acute neurologic impairments were reported after radiotherapy. One probable compressive optic neuropathy was observed at 1 year after radiotherapy. Conclusion: Fractionated radiotherapy achieves both symptomatic and radiologic improvements. It is a well-tolerated treatment modality for hemangiomas of the cavernous sinus.

키워드

참고문헌

  1. George A, Mani V, Noufal A. Update on the classification of hemangioma. J Oral Maxillofac Pathol 2014;18(Suppl 1):S117-20. https://doi.org/10.4103/0973-029X.141321
  2. Chou CW, Wu HM, Huang CI, et al. Gamma knife surgery for cavernous hemangiomas in the cavernous sinus. Neurosurgery 2010;67:611-6. https://doi.org/10.1227/01.NEU.0000378026.23116.E6
  3. Gonzalez LF, Lekovic GP, Eschbacher J, Coons S, Porter RW, Spetzler RF. Are cavernous sinus hemangiomas and cavernous malformations different entities? Neurosurg Focus 2006;21:e6.
  4. Linskey ME, Sekhar LN. Cavernous sinus hemangiomas: a series, a review, and an hypothesis. Neurosurgery 1992;30:101-8. https://doi.org/10.1227/00006123-199201000-00018
  5. Seo Y, Fukuoka S, Sasaki T, Takanashi M, Hojo A, Nakamura H. Cavernous sinus hemangioma treated with gamma knife radiosurgery: usefulness of SPECT for diagnosis: case report. Neurol Med Chir (Tokyo) 2000;40:575-80. https://doi.org/10.2176/nmc.40.575
  6. Shibata S, Mori K. Effect of radiation therapy on extracerebral cavernous hemangioma in the middle fossa: report of three cases. J Neurosurg 1987;67:919-22. https://doi.org/10.3171/jns.1987.67.6.0919
  7. Rigamonti D, Pappas CT, Spetzler RF, Johnson PC. Extracerebral cavernous angiomas of the middle fossa. Neurosurgery 1990;27:306-10. https://doi.org/10.1227/00006123-199008000-00024
  8. Yamamoto Y, Weining Z, Ohashi T. Intracavernous cavernous hemangioma: dynamic CT findings and effectiveness of irradiation: case report. Neurol Med Chir (Tokyo) 1992;32:93-5. https://doi.org/10.2176/nmc.32.93
  9. Jamjoom AB. Response of cavernous sinus hemangioma to radiotherapy: a case report. Neurosurg Rev 1996;19:261-4. https://doi.org/10.1007/BF00314842
  10. Kuo JS, Chen JC, Yu C, et al. Gamma knife radiosurgery for benign cavernous sinus tumors: quantitative analysis of treatment outcomes. Neurosurgery 2004;54:1385-94. https://doi.org/10.1227/01.NEU.0000124750.13721.94
  11. Grosu AL, Nieder C. Stereotactic fractionated radiotherapy for recurrent capillary hemangioma of the cavernous sinus. Strahlenther Onkol 2006;182:179-82. https://doi.org/10.1007/s00066-006-1473-4
  12. Wang X, Liu X, Mei G, Dai J, Pan L, Wang E. Phase II study to assess the efficacy of hypofractionated stereotactic radiotherapy in patients with large cavernous sinus hemangiomas. Int J Radiat Oncol Biol Phys 2012;83:e223-30. https://doi.org/10.1016/j.ijrobp.2011.12.051
  13. Wang X, Mei G, Liu X, Dai J, Pan L, Wang E. The role of stereotactic radiosurgery in cavernous sinus hemangiomas: a systematic review and meta-analysis. J Neurooncol 2012;107:239-45. https://doi.org/10.1007/s11060-011-0753-8
  14. Song SW, Kim DG, Chung HT, et al. Stereotactic radiosurgery for cavernous sinus hemangiomas. J Neurooncol 2014;118:163-8. https://doi.org/10.1007/s11060-014-1414-5
  15. Park CK, Choi SK, Kang IH, Choi MK, Park BJ, Lim YJ. Radiosurgical considerations for cavernous sinus hemangioma: long-term clinical outcomes. Acta Neurochir (Wien) 2016;158:313-8. https://doi.org/10.1007/s00701-015-2657-4
  16. Xu Q, Shen J, Feng Y, Zhan R. Gamma Knife radiosurgery for the treatment of cavernous sinus hemangiomas. Oncol Lett 2016;11:1545-8. https://doi.org/10.3892/ol.2015.4053
  17. Anqi X, Zhang S, Jiahe X, Chao Y. Cavernous sinus cavernous hemangioma: imaging features and therapeutic effect of Gamma Knife radiosurgery. Clin Neurol Neurosurg 2014;127:59-64. https://doi.org/10.1016/j.clineuro.2014.09.025
  18. Yamamoto M, Kida Y, Fukuoka S, et al. Gamma Knife radiosurgery for hemangiomas of the cavernous sinus: a seven-institute study in Japan. J Neurosurg 2010;112:772-9. https://doi.org/10.3171/2009.6.JNS08271
  19. Levegrun S, Hof H, Essig M, Schlegel W, Debus J. Radiationinduced changes of brain tissue after radiosurgery in patients with arteriovenous malformations: dose/volume-response relations. Strahlenther Onkol 2004;180:758-67. https://doi.org/10.1007/s00066-004-1266-6
  20. Mayo C, Martel MK, Marks LB, Flickinger J, Nam J, Kirkpatrick J. Radiation dose-volume effects of optic nerves and chiasm. Int J Radiat Oncol Biol Phys 2010;76(3 Suppl):S28-35. https://doi.org/10.1016/j.ijrobp.2009.07.1753
  21. Emami B, Lyman J, Brown A, et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 1991;21:109-22.

피인용 문헌

  1. Urethral cavernous hemangioma: a highly misdiagnosed disease (a case report of two patients and literature review) vol.19, pp.None, 2017, https://doi.org/10.1186/s12894-019-0441-0
  2. Fractionated Radiation Therapy for Large and Giant Cavernous Sinus Hemangioma: A Retrospective Study vol.11, pp.None, 2020, https://doi.org/10.3389/fneur.2020.00355
  3. Pronator Quadratus Hemangioma (PQH): A Rare Case Report and Review vol.55, pp.4, 2017, https://doi.org/10.1007/s43465-020-00295-0