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Recommended Rice Intake Levels Based on Average Daily Dose and Urinary Excretion of Cadmium in a Cadmium-Contaminated Area of Northwestern Thailand

  • La-Up, Aroon (Department of Community Medicine, Faculty of Medicine, Chiang Mai University) ;
  • Wiwatanadate, Phongtape (Department of Community Medicine, Faculty of Medicine, Chiang Mai University) ;
  • Pruenglampoo, Sakda (Research Institute for Health Sciences, Chiang Mai University) ;
  • Uthaikhup, Sureeporn (Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University)
  • 투고 : 2017.04.20
  • 심사 : 2017.07.04
  • 발행 : 2017.10.15

초록

This study was performed to investigate the dose-response relationship between average daily cadmium dose (ADCD) from rice and the occurrence of urinary cadmium (U-Cd) in individuals eating that rice. This was a retrospective cohort designed to compare populations from two areas with different levels of cadmium contamination. Five-hundred and sixty-seven participants aged 18 years or older were interviewed to estimate their rice intake, and were assessed for U-Cd. The sources of consumed rice were sampled for cadmium measurement, from which the ADCD was estimated. Binary logistic regression was used to examine the association between ADCD and U-Cd (cut-off point at $2{\mu}g/g$ creatinine), and a correlation between them was established. The lowest estimate was $ADCD=0.5{\mu}g/kg\;bw/day$ [odds ratio (OR) = 1.71; with a 95% confidence interval (CI) 1.02-2.87]. For comparison, the relationship in the contaminated area is expressed by $ADCD=0.7{\mu}g/kg\;bw/day$, OR = 1.84; [95 % CI, 1.06-3.19], while no relationship was found in the non-contaminated area, meaning that the highest level at which this relationship does not exist is $ADCD=0.6{\mu}g/kg\;bw/day$ [95% CI, 0.99-2.95]. Rice, as a main staple food, is the most likely source of dietary cadmium. Abstaining from or limiting rice consumption, therefore, will increase the likelihood of maintaining U-Cd within the normal range. As the recommended maximum ADCD is not to exceed $0.6{\mu}g/kg\;bw/day$, the consumption of rice grown in cadmium-contaminated areas should not be more than 246.8 g/day. However, the exclusion of many edible plants grown in the contaminated area from the analysis might result in an estimated ADCD that does not reflect the true level of cadmium exposure among local people.

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참고문헌

  1. Vacchi-Suzzi, C., Kruse, D., Harrington, J., Levine, K. and Meliker, J.R. (2016) Is urinary cadmium a biomarker of longterm exposure in humans? A review. Curr. Environ. Health Rep., 3, 450-458. https://doi.org/10.1007/s40572-016-0107-y
  2. Agency for Toxic Substances and Disease Registry (2008) Toxicological profile for cadmium, U.S. Department Of Health And Human Services Public Health Service, Atlanta, Georgia.
  3. Ilmiawati, C., Yoshida, T., Itoh, T., Nakagi, Y., Saijo, Y., Sugioka, Y., Sakamoto, M., Ikegami, A., Ogawa, M. and Kayama, F. (2015) Biomonitoring of mercury, cadmium, and lead exposure in Japanese children: a cross-sectional study. Environ. Health Prev. Med., 20, 18-27. https://doi.org/10.1007/s12199-014-0416-4
  4. Järup, L. and Akesson, A. (2009) Current status of cadmium as an environmental health problem. Toxicol. Appl. Pharmacol., 238, 201-208. https://doi.org/10.1016/j.taap.2009.04.020
  5. Ke, S., Cheng, X.-Y., Zhang, J.-Y., Jia, W.-J., Li, H., Luo, H.-F., Ge, P.-H., Liu, Z.-M., Wang, H.-M., He, J.-S. and Chen, Z.N. (2015) Estimation of the benchmark dose of urinary cadmium as the reference level for renal dysfunction: a large sample study in five cadmium polluted areas in China. BMC Public Health, 15, 656. https://doi.org/10.1186/s12889-015-2021-x
  6. Weaver, V.M., Kim, N.-S., Lee, B.-K., Parsons, P.J., Spector, J., Fadrowski, J., Jaar, B.G., Steuerwald, A.J., Todd, A.C., Simon, D. and Schwartz, B.S. (2011) Differences in urine cadmium associations with kidney outcomes based on serum creatinine and cystatin C. Environ. Res., 111, 1236-1242. https://doi.org/10.1016/j.envres.2011.07.012
  7. Egan, S.K., Bolger, P.M. and Carrington, C.D. (2007) Update of US FDA's Total Diet Study food list and diets. J. Expo. Sci. Environ. Epidemiol., 17, 573-582. https://doi.org/10.1038/sj.jes.7500554
  8. Kido, T., Sunaga, K., Nishijo, M., Nakagawa, H., Kobayashi, E. and Nogawa, K. (2004) The relation of individual cadmium concentration in urine with total cadmium intake in Kakehashi River basin, Japan. Toxicol. Lett., 152, 57-61. https://doi.org/10.1016/j.toxlet.2004.04.001
  9. Kobayashi, E., Okubo, Y., Suwazono, Y., Kido, T. and Nogawa, K. (2002) Dose-response relationship between total cadmium intake calculated from the cadmium concentration in rice collected from each household of farmers and renal dysfunction in inhabitants of the Jinzu River basin, Japan. J. Appl. Toxicol., 22, 431-436. https://doi.org/10.1002/jat.882
  10. Llobet, J., Falco, G., Casas, C., Teixido, A. and Domingo, J. (2003) Concentrations of arsenic, cadmium, mercury, and lead in common foods and estimated daily intake by children, adolescents, adults, and seniors of Catalonia, Spain. J. Agric. Food Chem., 51, 838-842. https://doi.org/10.1021/jf020734q
  11. Munoz, O., Bastias, J.M., Araya, M., Morales, A., Orellana, C., Rebolledo, R. and Velez, D. (2005) Estimation of the dietary intake of cadmium, lead, mercury, and arsenic by the population of Santiago (Chile) using a Total Diet Study. Food Chem. Toxicol., 43, 1647-1655. https://doi.org/10.1016/j.fct.2005.05.006
  12. Chunhabundit, R. (2016) cadmium exposure and potential health risk from foods in contaminated area, Thailand. Toxicol. Res., 32, 65-72. https://doi.org/10.5487/TR.2016.32.1.065
  13. Swaddiwudhipong, W., Nguntra, P., Kaewnate, Y., Mahasakpan, P., Limpatanachote, P., Aunjai, T., Jeekeeree, W., Punta, B., Funkhiew, T. and Phopueng, I. (2015) Human health effects from cadmium exposure: comparison between persons living in cadmium-contaminated and non-contaminated areas in Northwestern Thailand. Southeast Asian J. Trop. Med. Public Health, 46, 133-142.
  14. Simmons, R.W., Pongsakul, P., Saiyasitpanich, D. and Klinphoklap, S. (2005) Elevated levels of cadmium and zinc in paddy soils and elevated levels of cadmium in rice grain downstream of a zinc mineralized area in Thailand: implications for public health. Environ. Geochem. Health, 27, 501-511. https://doi.org/10.1007/s10653-005-7857-z
  15. U.S. Environmental Protection Agency (1992) Guidelines for Exposure Assessment.
  16. Guest, C. (1992) Design concepts in nutritional epidemiology. J. Epidemiol. Community Health, 46, 317.
  17. Kido, T. and Nogawa, K. (1993) Dose-response relationship between total cadmium intake and ${\beta}_2$-microglobulinuria using logistic regression analysis. Toxicol. Lett., 69, 113-120. https://doi.org/10.1016/0378-4274(93)90096-G
  18. Kobayashi, E., Okubo, Y., Suwazono, Y., Kido, T., Nishijo, M., Nakagawa, H. and Nogawa, K. (2002) Association between total cadmium intake calculated from the cadmium concentration in household rice and mortality among inhabitants of the cadmium-polluted Jinzu River basin of Japan. Toxicol. Lett., 129, 85-91. https://doi.org/10.1016/S0378-4274(01)00520-3
  19. Ogawa, T., Kobayashi, E., Okubo, Y., Suwazono, Y., Kido, T. and Nogawa, K. (2004) Relationship among prevalence of patients with Itai-itai disease, prevalence of abnormal urinary findings, and cadmium concentrations in rice of individual hamlets in the Jinzu River basin, Toyama prefecture of Japan. Int. J. Environ. Health Res., 14, 243-252. https://doi.org/10.1080/09603120410001725586
  20. Satarug, S. and Moore, M.R. (2004) Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ. Health Perspect., 112, 1099-1103. https://doi.org/10.1289/ehp.6751
  21. Titapiwatanakun, B. (2012) The Rice Situation In Thailand, Technical Assistance Consultant's Report, TA-REG, 74595.
  22. Uraguchi, S. and Fujiwara, T. (2012) Cadmium transport and tolerance in rice: perspectives for reducing grain cadmium accumulation. Rice (N Y), 5, 5. https://doi.org/10.1186/1939-8433-5-5
  23. Codex Alimentarius Commission (2011) Report of the 35th session of the Codex Committee on Food Additives and Contaminants, Fifth session, The Hague, The Netherlands.