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Case Study of Three Gastro-esophageal Reflux-induced Chronic Cough Patients Treated with Ojeok-san plus Saengmaek-san

오적산합생맥산(五積散合生脈散)으로 호전된 위식도 역류에 의한 만성기침 환자 3례

  • Lee, Jun-Hwan (Clinical Research Division, Korea Institute of Oriental Medicine) ;
  • Bhang, Yeon-Hee (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Jae-Hyo (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Do, Ha-Yoon (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Kwan-Il (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Jung, Hee-Jae (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Beom-Joon (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
  • 이준환 (한국한의학연구원 임상연구부) ;
  • 방연희 (경희대학교 대학원 임상한의학과 폐계내과학교실) ;
  • 김재효 (경희대학교 대학원 임상한의학과 폐계내과학교실) ;
  • 도하윤 (경희대학교 대학원 임상한의학과 폐계내과학교실) ;
  • 김관일 (경희대학교 대학원 임상한의학과 폐계내과학교실) ;
  • 정희재 (경희대학교 대학원 임상한의학과 폐계내과학교실) ;
  • 이범준 (경희대학교 대학원 임상한의학과 폐계내과학교실)
  • Received : 2017.09.04
  • Accepted : 2017.09.25
  • Published : 2017.09.30

Abstract

Objectives: Gastro-esophageal reflux-induced chronic cough is not easy to diagnose and treat. In this study, three patients diagnosed with this disease were treated with Ojeok-san plus Saengmaek-san. Methods: Three patients with chronic cough, suspected to be gastro-esophageal and reflux-based, were diagnosed according to symptoms and abdominal examinations. They were treated with the herbal medicine, Ojeok-san plus Saengmaek-san. To evaluate the effectiveness of the treatment, a visual analogue scale (VAS) for measuring the severity of a cough and the Korean version of the Leicester Cough Questionnaire (LCQ-K) were used to determine the patients' quality of life. Results: After administration of Ojeok-san plus Saengmaek-san, the severity of the patients' coughing decreased based on VAS scores and quality of life improved based on LCQ-K scores for all patients. Conclusions: Ojeok-san plus Saengmaek-san is a potent therapeutic agent for gastro-esophageal reflux-induced chronic cough.

Keywords

References

  1. Irwin RS, Madison JM. The diagnosis and treatment of cough. N Engl J Med 2000;343(23):1715-21. https://doi.org/10.1056/NEJM200012073432308
  2. Lee YC. Differential diagnosis and treatment of chronic cough. Korean J Med 2010;79(5):500-3.
  3. Kim H, Sung MW. Pathophysiology, Causes and Treatment of Chronic Cough in Adults: Literature Review. Korean J Otorhinolaryngol-Head Neck Surg 2015;58(11):744-53. https://doi.org/10.3342/kjorl-hns.2015.58.11.744
  4. Palombini BC, Villanova CAnC, Arau E, Gastal OvL, Alt DC, Stolz DP, et al. A pathogenic triad in chronic cough*: Asthma, postnasal drip syndrome, and gastroesophageal reflux disease. Chest 1999;116(2):279-84. https://doi.org/10.1378/chest.116.2.279
  5. Ko YI. Useful approach to the diagnosis and treatment of chronic cough. Korean J Med 2010;78(6):674-81.
  6. Pratter MR. Overview of common causes of chronic cough : ACCP evidence-based clinical practice guidelines. Chest 2006;129(1_suppl):59S-62S. https://doi.org/10.1378/chest.129.1_suppl.59S
  7. Chang AB, Lasserson TJ, Gaffney J, Connor FL, Garske LA. Gastro-oesophageal reflux treatment for prolonged non-specific cough in children and adults. Cochrane Database Syst Rev 2011;19(1):CD004823.
  8. Jee YG, Oh HT, Lee KY, Kim KY, Jo SH, Min KY, et al. A prospective study for spectrum and frequency of chronic cough in patient visiting out-patient clinic. Korean J Asthma Allergy Clin Immunol 1998;18(2):222-31.
  9. Irwin RS, French CL, Curley FJ, Zawacki JK, Bennett FM. Chronic cough due to gastroesophageal reflux. Clinical, diagnostic, and pathogenetic aspects. Chest 1993;104(5):1511-7. https://doi.org/10.1378/chest.104.5.1511
  10. Irwin RS, Baumann MH, Bolser DC, Boulet L-P, Braman SS, Brightling CE, et al. Diagnosis and management of cough executive summary : Accp evidence-based clinical practice guidelines. Chest 2006;129(1_suppl):1S-23S. https://doi.org/10.1378/chest.129.1_suppl.1S
  11. Kahrilas PJ, Altman KW, Chang AB, Field SK, Harding SM, Lane AP, et al. Chronic Cough due to Gastroesophageal Reflux in Adults: CHEST Guideline and Expert Panel Report. Chest 2016;150(6):1341-60. https://doi.org/10.1016/j.chest.2016.08.1458
  12. Shaheen NJ, Crockett SD, Bright SD, Madanick RD, Buckmire R, Couch M, et al. Randomised clinical trial: high dose acid suppression for chronic cough; a double blind, placebo controlled study. Aliment Pharmacol Ther 2011;33(2):225-34. https://doi.org/10.1111/j.1365-2036.2010.04511.x
  13. College of Oriental Medicine of Respiratory System. Oriental Internal Medicine of Respiratory System. Seoul: Nado; 2010, p. 220-4.
  14. Lee JG, Yang SY, Oh YS, Lee JW, Lee YK, Park YC. Two cases of chronic cough treated with Pyeongjingeonbi-tang. Daejeon University Oriental Medicine laboratory collection of dissertations 2011;19(2):159-64.
  15. Han JM. The Study for Assessing Reliability and Validity of Leicester Cough Questionaire Korean Version. Graduate School, Daejeon University 2013.
  16. Han JM, Jung IC, Kang W, Kim SS, Yeo Y, Park YC. Reliability and validity of Leicester Cough Questionnaire Korean version. Chronic Respiratory Disease 2014;11(3):147-52. https://doi.org/10.1177/1479972314536206
  17. Jung HK, Hong SJ, Jo YJ, Jeon SW, Cho YK, Lee KJ, et al. Updated guidelines 2012 for gastroesophageal reflux disease. Korean J Gastroenterol 2012;60:195-218. https://doi.org/10.4166/kjg.2012.60.4.195
  18. Jeon SG, Sohn CI, Kim JE, Park KH, Whang IS, Kim EJ, et al. Prevalence of gastroesophageal reflux in routine check-up subjects. Korean J Med 2000;58(2):145-51.
  19. Jung JW. The causes of chronic cough: Chronic cough due to extrapulmonary etiologies. Korean J Med 2010;78(6):670-3.
  20. Saritas Yuksel E, Vaezi MF. Extraesophageal manifestations of gastroesophageal reflux disease: cough, asthma, laryngitis, chest pain. Swiss medical weekly 2012;142:w13544.
  21. Baldi F, Cappiello R, Cavoli C, Ghersi S, Torresan F, Roda E. Proton pump inhibitor treatment of patients with gastroesophageal reflux-related chronic cough: A comparison between two different daily doses of lansoprazole. World J Gastroenterol 2006;12(1):82-8. https://doi.org/10.3748/wjg.v12.i1.82
  22. Nam SJ. Park SC, Lee SJ. Extraesophageal Manifestations of Gastroesophageal Reflux Disease. Korean J Med 2016;91(3):257-63. https://doi.org/10.3904/kjm.2016.91.3.257
  23. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R; Global Consensus Group. The montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006;101:1900-20. https://doi.org/10.1111/j.1572-0241.2006.00630.x
  24. Hwang IJ, Jung HC, Si KD, Yoon JH, Choi JH, Song HY, et al. Gastroesophageal Reflux Disease in Patients with Unexplained Chronic Cough. Kor J Neurogastroenterol Motil 2007;13(1):15-20.
  25. Kim HY, Kim NY, Kim SM, Suh JH, Park YS, Hwang JH, et al. Clinical spectrum and risk factors of erosive and non-erosive GERD in health check-up subjects. Korean J Med 2006;71(5):491-500.
  26. Sinn DH, Kim JH, Kim S, Son HJ, Kim JJ, Rhee JC, et al. Response rate and predictors of response in a short-term empirical trial of high-dose rabeprazole in patients with globus. Aliment Pharmacol Ther 2008;27(12):1275-81. https://doi.org/10.1111/j.1365-2036.2008.03659.x
  27. Lee KS, Kim NY, Park RY, Kim CH, Kim HY, Park YS, et al. The role of endoscopy, 24 hour ambulatory esophageal pH monitor and bernstein test for gastroesophageal reflux disease and its relationship with symptom. The Korean Journal of Medicine 2006;70(2):145-56.
  28. Joh KH, Kita T, Katsutoshita T. Moon SK, Ko CN, Kim YS, et al. An Introduction of Abdominal Palpation Signs in Japanese Oriental Medicine -a New Approach to The Practice of Abdominal Palpation in Korean Oriental Medicine-. J Int Korean Med 1997;18(1):86-96.
  29. 岡 孝, 松浦 達. 咽喉頭異常感症に對する随証治療による漢方薬の効果の檢討. 医療. 1989;43(10):1038-40.(14)
  30. Choi MK, Kim JK. Study on Application of the Herbal Medicines Mentioned in Sanghanron, GeumGweyoryak with Regards to the Abdominal Diagnoses Impressions of Epigastric Fullness and Rigidity. Korean J Oriental Physiology & Patholog 2006;20(6):1375-87.
  31. Yun JY, Yun YG. A Prescriptional Study of Ojeoksan on Clinical Application. Herbal formula science 2012;20(2):153-64. https://doi.org/10.14374/HFS.2012.20.2.153
  32. Lee SD, Kim EJ, Jung CY, Sin KM, Jang MK, Yun EH, et al. Selection of Adequate Indicators for the Development of a Questionnaire to Evaluate the Effects of Ojeock-san. J Korean Oriental Med 2010;31(4):101-14.
  33. Lee C, Jin JP. Ui-hag-ib-mun. Seoul: Bubin publishers co; 2009, p. 1319.
  34. Shin IS, Lee MY, Jeon WY, Kim JC, Shin HK. Ojeok-san, a traditional Korean herbal medicine attenuates airway inflammation and pulmonary fibrosis induced by repeated ovalbumin challenge. J Ethnopharmacol 2013;149(1):281-7. https://doi.org/10.1016/j.jep.2013.06.036
  35. Wang A, Chae IS, Maeng HS. Ui-bang-jib-hae. Seoul: Daesung publisher; 1992, p. 361.
  36. Ko KM. Shengmai san. New York: Taylor & Francis; 2002, p. 136.
  37. 楊愛武, 吕宏升, 張江灵, 林志敏, 梁仁佩. 生脉散加味對晚期肺腺癌患者化療毒副反應及臨床症狀, 生活質量的影響. 現代中西医結合雜志. 2016(33).
  38. 王玲, 居来提.赛買提, 楊衛江. 生脉散加味治療結締組織病合并肺間質纖維化. 中國現代医生. 2011(11).
  39. Kim BJ. Shengmaisan Regulates Pacemaker Potentials in Interstitial Cells of Cajal in Mice. Journal of pharmacopuncture 2013;16(4):36-42. https://doi.org/10.3831/KPI.2013.16.025
  40. Lee MC, Park JR, Shim JH, Ahn TS, Kim BJ. Effects of Traditional Chinese Herbal Medicine Shengmai-San and Pyungwi-San on Gastrointestinal Motility in Mice. J Korean Med Obes Res 2015;15(2):68-74. https://doi.org/10.15429/jkomor.2015.15.2.68
  41. Mahashur A. Chronic dry cough: Diagnostic and management approaches. Lung India : Official Organ of Indian Chest Society 2015;32(1):44-9. https://doi.org/10.4103/0970-2113.148450
  42. Boulet L-P, Coeytaux RR, McCrory DC, French CT, Chang AB, Birring SS, et al. Tools for assessing outcomes in studies of chronic cough: Chest guideline and expert panel report. Chest 2015;147(3):804-14. https://doi.org/10.1378/chest.14-2506
  43. Morice A, Fontana G, Belvisi M, Birring S, Chung K, Dicpinigaitis P, et al. ERS guidelines on the assessment of cough. European Respiratory Journal 2007;29(6):1256-76. https://doi.org/10.1183/09031936.00101006
  44. Brightling CE, Monterio W, Green RH, Parker D, Morgan MDL, Wardlaw AJ, et al. Induced sputum and other outcome measures in chronic obstructive pulmonary disease: safety and repeatability. Respiratory Medicine 2001;95(12):999-1002. https://doi.org/10.1053/rmed.2001.1195
  45. Spinou A, Birring SS. An update on measurement and monitoring of cough: what are the important study endpoints? J Thorac Dis 2014;6(Suppl 7):S728-S34.

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