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Acute Variation of Hematological Parameters during 622 km Ultra-Marathon

  • Shin, Kyung-A (Department of Clinical Laboratory Science, Shinsung University) ;
  • Kim, Young-Joo (Department of Exercise Rehabilitaion Welfare, Sungshin University)
  • Received : 2017.06.11
  • Accepted : 2017.08.07
  • Published : 2017.09.30

Abstract

To investigate the effects of strenuous physical exercise on commonly used hematological markers in subjects the intensive long running. Blood samples were obtained from nineteen participants in a 622 km ultra-marathon race before, 300 km and immediately after completion of the 622 km ultra-marathon. Samples were analyzed for total white cell count (WBC) and differential, total red cell count (RBC), hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), platelets, mean platelets volume (MPV), platelets distribution width (PDW). Significant increases were found in WBC, neutrophil and platelets at 622 km compared to the pre-race. RBC, hemoglobin and hematocrit decreased statistically significantly the race at 300 km and 622 km compared to pre-race. A wide range of hematological perturbations occur during 622 km ultra-marathon running but it was physiological changes within a reference range. The 622 km ultra-marathon is less likely to cause clinically significant hematologic changes in athletes.

Keywords

References

  1. Banfi G, Dolci A. Preanalytical phase of sport biochemistry and haematology. Journal of Sports Medicine and Physical Fitness. 2003. 43: 223-230.
  2. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, Mohler ER, Reilly MP, Berger JS. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. Journal of Thrombosis and Haemostasis 2010. 8: 148-156. https://doi.org/10.1111/j.1538-7836.2009.03584.x
  3. Crouse B, Beattie K. Marathon medical services: strategies to reduce runner morbidity. Medicine and Science in Sports and Exercise. 1996. 28: 1093-1096. https://doi.org/10.1097/00005768-199609000-00003
  4. Drygas W, Rebowska E, Stepien E, Golanski J, Kwasniewska M. Biochemical and hematological changes following the 120-km open-water marathon swim. Journal of Sports Science and Medicine. 2014. 13: 632-637.
  5. Eichner ER. The Anemias of Athletes. Physician and Sportsmedicine. 1986. 14: 122-130.
  6. Fallon KE, Sivyer G, Sivyer K, Dare A. Changes in haematological parameters and iron metabolism associated with a 1600 kilometre ultramarathon. British Journal of Sports Medicine. 1999. 33: 27-31. https://doi.org/10.1136/bjsm.33.1.27
  7. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Current Pharmaceutical Design. 2011. 17: 47-58. https://doi.org/10.2174/138161211795049804
  8. Gibbons RJ, Balady GJ, Bricker JT, Chaitman BR, Fletcher GF, Froelicher VF, Mark DB, McCallister BD, Mooss AN, O'Reilly MG, Winters WL, Gibbons RJ, Antman EM, Alpert JS, Faxon DP, Fuster V, Gregoratos G, Hiratzka LF, Jacobs AK, Russell RO, Smith SC. American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Committee to Update the 1997 Exercise Testing Guidelines. ACC/AHA 2002 guideline update for exercise testing: summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). Journal of the American College of Cardiology. 2002. 40: 1531-1540. https://doi.org/10.1016/S0735-1097(02)02164-2
  9. Jordan J, Kiernan W, Merker HJ, Wenzel M, Beneke R. Red cell membrane skeletal changes in marathon runners. International Journal of Sports Medicine. 1998. 19: 16-19. https://doi.org/10.1055/s-2007-971873
  10. Kratz A, Lewandrowski KB, Siegel AJ, Chun KY, Flood JG, Van Cott EM, Lee-Lewandrowski E. Effect of marathon running on hematologic and biochemical laboratory parameters, including cardiac markers. American Journal of Clinical Pathology. 2002. 118: 856-863. https://doi.org/10.1309/14TY-2TDJ-1X0Y-1V6V
  11. Lippi G, Banfi G, Montagnana M, Salvagno GL, Schena F, Guidi GC. Acute variation of leucocytes counts following a halfmarathon run. International Journal of Laboratory Hematology. 2010. 32: 117-121. https://doi.org/10.1111/j.1751-553X.2008.01133.x
  12. Lippi G, Salvagno GL, Danese E, Tarperi C, Guidi GC, Schena F. Variation of red blood cell distribution width and mean platelet volume after moderate endurance exercise. Advances in Hematology. 2014. 192173.
  13. Martin TG, Pata RW, D'Addario J, Yuknis L, Kingston R, Feinn R. Impact of age on haematological markers pre- and postmarathon running. Journal of Sports Sciences. 2015. 33: 1988-1997. https://doi.org/10.1080/02640414.2015.1024712
  14. Mohseni M, Silvers S, McNeil R, Diehl N, Vadeboncoeur T, Taylor W, Shapiro S, Roth J, Mahoney S. Prevalence of hyponatremia, renal dysfunction, and other electrolyte abnormalities among runners before and after completing a marathon or half marathon. Sports Health. 2011. 3: 145-151. https://doi.org/10.1177/1941738111400561
  15. Natale VM, Brenner IK, Moldoveanu AI, Vasiliou P, Shek P, Shephard RJ. Effects of three different types of exercise on blood leukocyte count during and following exercise. Sao Paulo Medical Journal. 2003. 121: 9-14. https://doi.org/10.1590/S1516-31802003000100003
  16. Nieman DC. Marathon training and immune function. Sports Medicine. 2007. 37: 412-415. https://doi.org/10.2165/00007256-200737040-00036
  17. Peters EM. Exercise, immunology and upper respiratory tract infections. International Journal of Sports Medicine. 1997. 18:S69-77. https://doi.org/10.1055/s-2007-972702
  18. Pyne DB. Regulation of neutrophil function during exercise. Sports Medicine. 1994. 17: 245-258. https://doi.org/10.2165/00007256-199417040-00005
  19. Roberts WO. A 12-yr profile of medical injury and illness for the Twin Cities Marathon. Medicine and Science in Sports and Exercise . 2000. 32: 1549-1555.
  20. Sanchez LD, Corwell B, Berkoff D. Medical problems of marathon runners. American Journal of Emergency Medicine. 2006. 24:608-615. https://doi.org/10.1016/j.ajem.2006.01.023
  21. Shin KA, Kim YJ. Comparison of the Muscle Damage and Liver Function in Ultra-Marathon Race (100 km) by Sections. Biomedical Science Letters. 2012. 18: 276-282.
  22. Smith JA. Exercise, training and red blood cell turnover. Sports Medicine. 1995. 19: 9-31. https://doi.org/10.2165/00007256-199519010-00002
  23. Smith JE, Garbutt G, Lopes P, Tunstall Pedoe D. Effects of prolonged strenuous exercise (marathon running) on biochemical and haematological markers used in the investigation of patients in the emergency department. British Journal of Sports Medicine. 2004. 38: 292-294. https://doi.org/10.1136/bjsm.2002.002873
  24. Spiropoulos K, Trakada G. Hematologic and biochemical laboratory parameters before and after a marathon race. Lung. 2003. 181: 89-95. https://doi.org/10.1007/s00408-003-1009-y
  25. Traiperm N, Gatterer H, Burtscher M. Plasma electrolyte and hematological changes after marathon running in adolescents. Medicine and Science in Sports and Exercise. 2013. 45: 1182-1187. https://doi.org/10.1249/MSS.0b013e3182831a93
  26. Waskiewicz Z, Klapcinska B, Sadowska-Krepa E, Czuba M, Kempa K, Kimsa E, Gerasimuk D. Acute metabolic responses to a 24-h ultra-marathon race in male amateur runners. European Journal of Applied Physiology. 2012. 112: 1679-1688. https://doi.org/10.1007/s00421-011-2135-5
  27. Wu HJ, Chen KT, Shee BW, Chang HC, Huang YJ, Yang RS. Effects of 24 h ultra-marathon on biochemical and hematological parameters. World Journal of Gastroenterology. 2004. 10: 2711-2714. https://doi.org/10.3748/wjg.v10.i18.2711