DOI QR코드

DOI QR Code

Differences in the Korea Acute Myocardial Infarction Registry Compared with Western Registries

  • Sim, Doo Sun (The Heart Center of Chonnam National University Hospital) ;
  • Jeong, Myung Ho (The Heart Center of Chonnam National University Hospital)
  • Received : 2017.01.31
  • Accepted : 2017.05.31
  • Published : 2017.11.30

Abstract

The Korea Acute Myocardial Infarction Registry (KAMIR) is the first nationwide registry that reflects current therapeutic approaches and acute myocardial infarction (AMI) management in Korea. The results of the KAMIR demonstrated different risk factors and responses to medical and interventional treatments. The results indicated that the incidence of ST-elevation myocardial infarction (STEMI) was relatively high, and that the prevalence of dyslipidemia was relatively low with higher triglyceride and lower high-density lipoprotein cholesterol levels. Percutaneous coronary intervention (PCI) rates were high for both STEMI and non-ST-elevation myocardial infarction (NSTEMI) with higher use of drug-eluting stents (DESs). DES were effective and safe without increased risk of stent thrombosis in Korean AMI patients. Triple antiplatelet therapy, consisting of aspirin, clopidogrel, and cilostazol, was effective in preventing adverse clinical outcomes after PCI. Statin therapy was effective in Korean AMI patients, including those with very low levels of low-density lipoprotein cholesterol and those with cardiogenic shock. The KAMIR score had a greater predictive value than Thrombolysis in Myocardial Infarction (TIMI) and Global Registry of Acute Coronary Events (GRACE) scores for long-term mortality in AMI patients. Based on these results, the KAMIR will be instrumental for establishing new therapeutic strategies and effective methods for secondary prevention of AMI and guidelines for Asian patients.

Keywords

References

  1. Kook HY, Jeong MH, Oh S, et al. Current trend of acute myocardial infarction in Korea (from the Korea Acute Myocardial Infarction Registry from 2006 to 2013). Am J Cardiol 2014;114:1817-22. https://doi.org/10.1016/j.amjcard.2014.09.019
  2. Kim JH, Chae SC, Oh DJ, et al. Multicenter cohort study of acute myocardial infarction in Korea: interim analysis of the Korea Acute Myocardial Infarction Registry-National Institutes of Health Registry. Circ J 2016;80:1427-36. https://doi.org/10.1253/circj.CJ-16-0061
  3. Park KH, Jeong MH, Ahn Y, et al. Comparison of short-term clinical outcomes between ticagrelor versus clopidogrel in patients with acute myocardial infarction undergoing successful revascularization; from Korea Acute Myocardial Infarction Registry-National Institute of Health. Int J Cardiol 2016;215:193-200. https://doi.org/10.1016/j.ijcard.2016.04.044
  4. Yang JH, Hahn JY, Song YB, et al. Angiotensin receptor blocker in patients with ST segment elevation myocardial infarction with preserved left ventricular systolic function: prospective cohort study. BMJ 2014;349:g6650. https://doi.org/10.1136/bmj.g6650
  5. Kim KH, Kim CH, Jeong MH, et al. Differential benefit of statin in secondary prevention of acute myocardial infarction according to the level of triglyceride and high density lipoprotein cholesterol. Korean Circ J 2016;46:324-34. https://doi.org/10.4070/kcj.2016.46.3.324
  6. Hong YJ, Jeong MH, Ahn Y, Kang JC. The efficacy and safety of drug-eluting stents in patients with acute myocardial infarction: results from Korea Acute Myocardial Infarction (KAMIR). Int J Cardiol 2013;163:1-4. https://doi.org/10.1016/j.ijcard.2012.02.003
  7. Jeong YA, Jeong MH, Jeong HC, et al. Impact of smoking on clinical outcomes in female patients with acute myocardial infarction. Korean Circ J 2015;45:22-7. https://doi.org/10.4070/kcj.2015.45.1.22
  8. Kim JS, Kim W, Woo JS, et al. The predictive role of serum triglyceride to high-density lipoprotein cholesterol ratio according to renal function in patients with acute myocardial infarction. PLoS One 2016;11:e0165484. https://doi.org/10.1371/journal.pone.0165484
  9. Ji MS, Jeong MH, Ahn YK, et al. Impact of low level of high-density lipoprotein-cholesterol sampled in overnight fasting state on the clinical outcomes in patients with acute myocardial infarction (difference between ST-segment and non-ST-segment-elevation myocardial infarction). J Cardiol 2015;65:63-70. https://doi.org/10.1016/j.jjcc.2014.04.002
  10. Cho KH, Jeong MH, Park KW, et al. Comparison of the effects of two low-density lipoprotein cholesterol goals for secondary prevention after acute myocardial infarction in real-world practice: $\geq$ 50% reduction from baseline versus <70 mg/dL. Int J Cardiol 2015;187:478-85. https://doi.org/10.1016/j.ijcard.2015.03.386
  11. Cho JY, Jeong MH, Ahn Y, et al. Impact of high admission blood pressure without history of hypertension on clinical outcomes of patients with acute myocardial infarction: from Korea Acute Myocardial Infarction Registry. Int J Cardiol 2014;172:e54-8. https://doi.org/10.1016/j.ijcard.2013.12.063
  12. Lee SA, Cho SJ, Jeong MH, et al. Hypoglycemia at admission in patients with acute myocardial infarction predicts a higher 30-day mortality in patients with poorly controlled type 2 diabetes than in well-controlled patients. Diabetes Care 2014;37:2366-73. https://doi.org/10.2337/dc13-2856
  13. Yoo SH, Kook HY, Hong YJ, Kim JH, Ahn Y, Jeong MH. Influence of undernutrition at admission on clinical outcomes in patients with acute myocardial infarction. J Cardiol 2017;69:555-60. https://doi.org/10.1016/j.jjcc.2016.05.009
  14. Sim DS, Jeong MH, Ahn Y, et al. Pharmacoinvasive strategy versus primary percutaneous coronary intervention in patients with ST-segment-elevation myocardial infarction: a propensity score-matched analysis. Circ Cardiovasc Interv 2016;9:e003508.
  15. Kim HK, Jeong MH, Ahn Y, et al. Relationship between time to treatment and mortality among patients undergoing primary percutaneous coronary intervention according to Korea Acute Myocardial Infarction Registry. J Cardiol 2017;69:377-82. https://doi.org/10.1016/j.jjcc.2016.09.002
  16. Sim DS, Jeong MH, Ahn Y, et al. Safety and benefit of early elective percutaneous coronary intervention after successful thrombolytic therapy for acute myocardial infarction. Am J Cardiol 2009;103:1333-8. https://doi.org/10.1016/j.amjcard.2009.01.339
  17. Danchin N, Coste P, Ferrieres J, et al. Comparison of thrombolysis followed by broad use of percutaneous coronary intervention with primary percutaneous coronary intervention for ST-segment-elevation acute myocardial infarction: data from the french registry on acute ST-elevation myocardial infarction (FAST-MI). Circulation 2008;118:268-76. https://doi.org/10.1161/CIRCULATIONAHA.107.762765
  18. Armstrong PW, Gershlick AH, Goldstein P, et al. Fibrinolysis or primary PCI in ST-segment elevation myocardial infarction. N Engl J Med 2013;368:1379-87. https://doi.org/10.1056/NEJMoa1301092
  19. Kushner FG, Hand M, Smith SC Jr, et al. 2009 focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guideline and 2007 focused update) a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2009;54:2205-41. https://doi.org/10.1016/j.jacc.2009.10.015
  20. Van de Werf F, Bax J, Betriu A, et al. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the task force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology. Eur Heart J 2008;29:2909-45. https://doi.org/10.1093/eurheartj/ehn416
  21. Sim DS, Jeong MH, Ahn Y, et al. Benefit of percutaneous coronary intervention in early latecomers with acute ST-segment elevation myocardial infarction. Am J Cardiol 2012;110:1275-81. https://doi.org/10.1016/j.amjcard.2012.06.028
  22. Riezebos RK, Verheugt FW. Timing of angiography in non-ST elevation myocardial infarction. Heart 2013;99:1867-73. https://doi.org/10.1136/heartjnl-2012-302034
  23. Sim DS, Jeong MH, Ahn Y, et al. Clinical impact of immediate invasive strategy in patients with non-ST-segment elevation myocardial infarction. Int J Cardiol 2016;221:937-43. https://doi.org/10.1016/j.ijcard.2016.07.128
  24. Hachinohe D, Jeong MH, Saito S, et al. Management of non-ST-segment elevation acute myocardial infarction in patients with chronic kidney disease (from the Korea Acute Myocardial Infarction Registry). Am J Cardiol 2011;108:206-13. https://doi.org/10.1016/j.amjcard.2011.03.025
  25. Piao ZH, Jeong MH, Jin L, et al. Clinical impact of early intervention in octogenarians with non-ST-elevation myocardial infarction. Int J Cardiol 2014;172:462-4. https://doi.org/10.1016/j.ijcard.2013.12.282
  26. Sim DS, Ahn Y, Jeong MH, et al. Clinical outcome of unprotected left main coronary artery disease in patients with acute myocardial infarction. Int Heart J 2013;54:185-91. https://doi.org/10.1536/ihj.54.185
  27. Kim MC, Jeong MH, Ahn Y, et al. What is optimal revascularization strategy in patients with multivessel coronary artery disease in non-ST-elevation myocardial infarction? Multivessel or culprit-only revascularization. Int J Cardiol 2011;153:148-53. https://doi.org/10.1016/j.ijcard.2010.08.044
  28. Kim MC, Jeong MH, Park KH, et al. Three-year clinical outcomes of staged, ad hoc and culprit-only percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction and multivessel disease. Int J Cardiol 2014;176:505-7. https://doi.org/10.1016/j.ijcard.2014.07.054
  29. Sim DS, Jeong MH, Ahn Y, et al. Effectiveness of drug-eluting stents versus bare-metal stents in large coronary arteries in patients with acute myocardial infarction. J Korean Med Sci 2011;26:521-7. https://doi.org/10.3346/jkms.2011.26.4.521
  30. Ahmed K, Jeong MH, Chakraborty R, et al. Comparison of zotarolimus- and everolimus-eluting stents in patients with ST-elevation myocardial infarction and chronic kidney disease undergoing primary percutaneous coronary intervention. J Cardiol 2014;64:273-8. https://doi.org/10.1016/j.jjcc.2014.02.002
  31. Piao ZH, Jeong MH, Li Y, et al. Comparison of second-generation drug-eluting versus bare-metal stents in octogenarian patients with ST-segment elevation myocardial infarction. Int J Cardiol 2014;177:1081-4. https://doi.org/10.1016/j.ijcard.2014.10.007
  32. Ji MS, Jeong MH, Ahn YK, et al. Comparison of resolute zotarolimus-eluting stents versus everolimus-eluting stents in patients with metabolic syndrome and acute myocardial infarction: propensity score-matched analysis. Int J Cardiol 2015;199:53-62. https://doi.org/10.1016/j.ijcard.2015.07.010
  33. Ahmed K, Jeong MH, Chakraborty R, et al. Role of intravascular ultrasound in patients with acute myocardial infarction undergoing percutaneous coronary intervention. Am J Cardiol 2011;108:8-14. https://doi.org/10.1016/j.amjcard.2011.02.339
  34. Vlaar PJ, Svilaas T, van der Horst IC, et al. Cardiac death and reinfarction after 1 year in the thrombus aspiration during percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS): a 1-year follow-up study. Lancet 2008;371:1915-20. https://doi.org/10.1016/S0140-6736(08)60833-8
  35. Frobert O, Lagerqvist B, Olivecrona GK, et al. Thrombus aspiration during ST-segment elevation myocardial infarction. N Engl J Med 2013;369:1587-97. https://doi.org/10.1056/NEJMoa1308789
  36. Lagerqvist B, Frobert O, Olivecrona GK, et al. Outcomes 1 year after thrombus aspiration for myocardial infarction. N Engl J Med 2014;371:1111-20. https://doi.org/10.1056/NEJMoa1405707
  37. Hachinohe D, Jeong MH, Saito S, et al. Clinical impact of thrombus aspiration during primary percutaneous coronary intervention: results from Korea Acute Myocardial Infarction Registry. J Cardiol 2012;59:249-57. https://doi.org/10.1016/j.jjcc.2011.12.005
  38. Sim DS, Jeong MH, Ahn Y, et al. Manual thrombus aspiration during primary percutaneous coronary intervention: Impact of total ischemic time. J Cardiol 2017;69:428-35. https://doi.org/10.1016/j.jjcc.2016.01.003
  39. Chen KY, Rha SW, Li YJ, et al. Triple versus dual antiplatelet therapy in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Circulation 2009;119:3207-14. https://doi.org/10.1161/CIRCULATIONAHA.108.822791
  40. Park KH, Jeong MH, Lee KH, et al. Comparison of peri-procedural platelet inhibition with prasugrel versus adjunctive cilostazol to dual anti-platelet therapy in patients with ST segment elevation myocardial infarction. J Cardiol 2014;63:99-105. https://doi.org/10.1016/j.jjcc.2013.07.004
  41. American College of Emergency Physicians2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013;61:e78-140.
  42. Yang JH, Hahn JY, Song YB, et al. Association of beta-blocker therapy at discharge with clinical outcomes in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. JACC Cardiovasc Interv 2014;7:592-601. https://doi.org/10.1016/j.jcin.2013.12.206
  43. Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC)Steg PG, James SK, et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 2012;33:2569-619. https://doi.org/10.1093/eurheartj/ehs215
  44. O'Gara PT, Kushner FG, Ascheim DD, et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2013;127:e362-425.
  45. Jeong HC, Jeong MH, Ahn Y, et al. Comparative assessment of angiotensin II type 1 receptor blockers in the treatment of acute myocardial infarction: surmountable vs. insurmountable antagonist. Int J Cardiol 2014;170:291-7. https://doi.org/10.1016/j.ijcard.2013.07.146
  46. Park H, Kim HK, Jeong MH, et al. Clinical impacts of inhibition of renin-angiotensin system in patients with acute ST-segment elevation myocardial infarction who underwent successful late percutaneous coronary intervention. J Cardiol 2017;69:216-21. https://doi.org/10.1016/j.jjcc.2016.03.012
  47. Cannon CP, Braunwald E, McCabe CH, et al. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 2004;350:1495-504. https://doi.org/10.1056/NEJMoa040583
  48. Schwartz GG, Olsson AG, Ezekowitz MD, et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial. JAMA 2001;285:1711-8. https://doi.org/10.1001/jama.285.13.1711
  49. Lee KH, Jeong MH, Kim HM, et al. Benefit of early statin therapy in patients with acute myocardial infarction who have extremely low low-density lipoprotein cholesterol. J Am Coll Cardiol 2011;58:1664-71. https://doi.org/10.1016/j.jacc.2011.05.057
  50. Sim DS, Jeong MH, Cho KH, et al. Effect of early statin treatment in patients with cardiogenic shock complicating acute myocardial infarction. Korean Circ J 2013;43:100-9. https://doi.org/10.4070/kcj.2013.43.2.100
  51. Piao ZH, Jeong MH, Li Y, et al. Benefit of statin therapy in patients with coronary spasm-induced acute myocardial infarction. J Cardiol 2016;68:7-12. https://doi.org/10.1016/j.jjcc.2015.09.013
  52. Ji MS, Jeong MH, Ahn YK, et al. Clinical outcome of statin plus ezetimibe versus high-intensity statin therapy in patients with acute myocardial infarction propensity-score matching analysis. Int J Cardiol 2016;225:50-9. https://doi.org/10.1016/j.ijcard.2016.09.082
  53. Kim HK, Jeong MH, Ahn Y, et al. A new risk score system for the assessment of clinical outcomes in patients with non-ST-segment elevation myocardial infarction. Int J Cardiol 2010;145:450-4. https://doi.org/10.1016/j.ijcard.2009.06.001
  54. Kim HK, Jeong MH, Ahn Y, et al. Hospital discharge risk score system for the assessment of clinical outcomes in patients with acute myocardial infarction (Korea Acute Myocardial Infarction Registry [KAMIR] score). Am J Cardiol 2011;107:965-971.e1. https://doi.org/10.1016/j.amjcard.2010.11.018
  55. Jeong YW, Jeong MH, Kim SS, et al. CHA2DS2-VASc scoring system as an initial method for screening high-risk patients in acute myocardial infarction. Int J Cardiol 2014;174:777-80. https://doi.org/10.1016/j.ijcard.2014.04.055
  56. Kim HK, Jeong MH, Seo HW, et al. Clinical impacts of high-sensitivity C-reactive protein reduction for secondary prevention in Asian patients with one-year survivor after acute myocardial infarction. Int J Cardiol 2015;193:20-2. https://doi.org/10.1016/j.ijcard.2015.05.017
  57. Lee JH, Bae MH, Yang DH, et al. Prognostic value of the age, creatinine, and ejection fraction score for 1-year mortality in 30-day survivors who underwent percutaneous coronary intervention after acute myocardial infarction. Am J Cardiol 2015;115:1167-73. https://doi.org/10.1016/j.amjcard.2015.02.001
  58. Park DW, Clare RM, Schulte PJ, et al. Extent, location, and clinical significance of non-infarct-related coronary artery disease among patients with ST-elevation myocardial infarction. JAMA 2014;312:2019-27. https://doi.org/10.1001/jama.2014.15095

Cited by

  1. Predictors of One-Year Mortality in Smokers with Acute Myocardial Infarction vol.93, pp.4, 2017, https://doi.org/10.3904/kjm.2018.93.4.369
  2. Long-term clinical outcomes according to the mean observed blood pressure in patients with coronary artery disease after drug-eluting stent implantation vol.37, pp.9, 2017, https://doi.org/10.1097/hjh.0000000000002127
  3. Outpatient Register of Patients with Acute Myocardial Infarction: Assessment of the Hypertension Impact on Long-term Prognosis vol.15, pp.5, 2019, https://doi.org/10.20996/1819-6446-2019-15-5-706-712
  4. High-resolution metabolomics study revealing L-homocysteine sulfinic acid, cysteic acid, and carnitine as novel biomarkers for high acute myocardial infarction risk vol.104, pp.None, 2017, https://doi.org/10.1016/j.metabol.2019.154051
  5. Contemporary Status of Acute Myocardial Infarction in Korean Patients: Korean Registry of Acute Myocardial Infarction for Regional Cardiocerebrovascular Centers vol.10, pp.3, 2017, https://doi.org/10.3390/jcm10030498
  6. Self-care and related factors associated with left ventricular systolic function in patients under follow-up after myocardial infarction vol.20, pp.1, 2021, https://doi.org/10.1177/1474515120923201
  7. Machine learning enhances the performance of short and long-term mortality prediction model in non-ST-segment elevation myocardial infarction vol.11, pp.1, 2017, https://doi.org/10.1038/s41598-021-92362-1