Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
권호 표지
DOI QR코드

DOI QR Code

Baseline Characteristics of a Retrospective Patient Cohort in the Korean Vascular Intervention Society Endovascular Therapy in Lower Limb Artery Diseases (K-VIS ELLA) Registry

  • Ko, Young-Guk (Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine) ;
  • Ahn, Chul-Min (Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine) ;
  • Min, Pil-Ki (Division of Cardiology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Lee, Jae-Hwan (Division of Cardiology, Department of Internal Medicine, Chungnam National University Hospital) ;
  • Yoon, Chang-Hwan (Seoul National University Bundang Hospital) ;
  • Yu, Cheol Woong (Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital) ;
  • Lee, Seung Whan (Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Sang-Rok (Division of Cardiology, Department of Internal Medicine, Chonbuk National University Hospital) ;
  • Choi, Seung Hyuk (Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Koh, Yoon Seok (Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Chae, In-Ho (Seoul National University Bundang Hospital) ;
  • Choi, Donghoon (Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine)
  • Received : 2017.01.26
  • Accepted : 2017.04.10
  • Published : 2017.07.31
⟨ Previous Next ⟩

Abstract

Background and Objectives: The Korean Vascular Intervention Society Endovascular Therapy in Lower Limb Artery Diseases (K-VIS ELLA) Registry is a multicenter observational study with retrospective and prospective cohorts of patients with lower extremity peripheral artery disease (PAD) undergoing endovascular treatment. In this study, we report the baseline characteristics of this retrospective cohort. Subjects and Methods: In the present study we analyzed datasets of 3073 patients with 3972 target limbs from a retrospective cohort treated with endovascular therapy in 31 Korean hospitals. Data regarding patient baseline clinical and lesion characteristics and post-intervention medications were collected from electronic medical records. Results: The mean patient age was $68.3{\pm}9.4$ years. The majority were male (82.1%) with comorbidities such as diabetes mellitus (58.0%), hypertension (73.4%), and coronary artery disease (CAD; 55.3%). Patients more commonly presented with intermittent claudication (66.3%) than with critical limb ischemia (CLI; 33.7%). Femoropopliteal artery (41.2%) was the most common target vessel for endovascular treatment, followed by the aortoiliac (35.6%) and infrapopliteal arteries (23.2%). TransAtlantic Inter-Society Consensus for the Management of Peripheral Artery Disease (TASC II) type C/D aortoiliac (48.0%) or femoropopliteal lesions (60.2%) were frequent targets of endovascular treatment. At hospital discharge, only 73.1% of patients received dual antiplatelet therapy and 69.2% received a statin. Conclusion: The majority of Korean patients with PAD exhibited conventional risk factors, such as male sex, older age, diabetes, and hypertension with coexisting CAD. Complex lesions were frequently treated with endovascular therapy. However, the rate of adherence to guidelines regarding post-procedural medical treatment requires improvement.

Keywords

References

  1. Norgren L, Hiatt WR, Dormandy JA, et al. Inter-society consensus for the management of peripheral arterial disease (TASC II). J Vasc Surg 2007;45 Suppl S:S5-67. https://doi.org/10.1016/j.jvs.2006.12.037
  2. European Stroke Organisation, Tendera M, Aboyans V, et al. ESC guidelines on the diagnosis and treatment of peripheral artery diseases: document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries: the task force on the diagnosis and treatment of peripheral artery diseases of the European Society of Cardiology (ESC). Eur Heart J 2011;32:2851-906. https://doi.org/10.1093/eurheartj/ehr211
  3. Hirsch AT, Haskal ZJ, Hertzer NR, et al. ACC/AHA 2005 practice guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA task force on practice guidelines (writing committee to develop guidelines for the management of patients with peripheral arterial disease): endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-society Consensus; and Vascular Disease Foundation. Circulation 2006;113:e463-654. https://doi.org/10.1161/circ.113.4.463
  4. Bhatt DL, Steg PG, Ohman EM, et al. International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. JAMA 2006;295:180-9. https://doi.org/10.1001/jama.295.2.180
  5. Heald CL, Fowkes FG, Murray GD, Price JF, Ankle Brachial Index Collaboration. Risk of mortality and cardiovascular disease associated with the ankle-brachial index: systematic review. Atherosclerosis 2006;189:61-9. https://doi.org/10.1016/j.atherosclerosis.2006.03.011
  6. Park YY, Joh JH, Han SA, et al. National trends for the treatment of peripheral arterial disease in Korea between 2004 and 2013. Ann Surg Treat Res 2015;89:319-24. https://doi.org/10.4174/astr.2015.89.6.319
  7. Rutherford RB, Baker JD, Ernst C, et al. Recommended standards for reports dealing with lower extremity ischemia: revised version. J Vasc Surg 1997;26:517-38. https://doi.org/10.1016/S0741-5214(97)70045-4
  8. World Health Organization. Nutritional anemia. Report of a WHO scientific group. World Health Organ Tech Rep Ser 1968;405:5-37.
  9. Kim MH, Ahn S, Kim JY, Jun KW, Yun SS, Won YS. Current trends of major arterial diseases in Korea: based on data from the health insurance review and assessment service. Ann Surg Treat Res 2016;90:218-23. https://doi.org/10.4174/astr.2016.90.4.218
  10. Howard DP, Banerjee A, Fairhead JF, et al. Population-based study of incidence, risk factors, outcome, and prognosis of ischemic peripheral arterial events: implications for prevention. Circulation 2015;132:1805-15. https://doi.org/10.1161/CIRCULATIONAHA.115.016424
  11. Farber A, Eberhardt RT. The current state of critical limb ischemia: a systematic review. JAMA Surg 2016;151:1070-7. https://doi.org/10.1001/jamasurg.2016.2018
  12. Iida O, Nakamura M, Yamauchi Y, et al. Endovascular treatment for infrainguinal vessels in patients with critical limb ischemia: OLIVE registry, a prospective, multicenter study in Japan with 12-month follow-up. Circ Cardiovasc Interv 2013;6:68-76. https://doi.org/10.1161/CIRCINTERVENTIONS.112.975318
  13. Soga Y, Mii S, Iida O, et al. Propensity score analysis of clinical outcome after bypass surgery vs. endovascular therapy for infrainguinal artery disease in patients with critical limb ischemia. J Endovasc Ther 2014;21:243-53. https://doi.org/10.1583/13-4510MR.1
  14. Agarwal S, Sud K, Shishehbor MH. Nationwide trends of hospital admission and outcomes among critical limb ischemia patients: from 2003-2011. J Am Coll Cardiol 2016;67:1901-13.
  15. Bisdas T, Borowski M, Stavroulakis K, Torsello G, CRITISCH Collaborators. Endovascular therapy versus bypass surgery as firstline treatment strategies for critical limb ischemia: results of the interim analysis of the CRITISCH registry. JACC Cardiovasc Interv 2016;9:2557-65. https://doi.org/10.1016/j.jcin.2016.09.039
  16. Sigvant B, Kragsterman B, Falkenberg M, et al. Contemporary cardiovascular risk and secondary preventive drug treatment patterns in peripheral artery disease patients undergoing revascularization. J Vasc Surg 2016;64:1009-17. e3. https://doi.org/10.1016/j.jvs.2016.03.429
  17. Westin GG, Armstrong EJ, Bang H, et al. Association between statin medications and mortality, major adverse cardiovascular event, and amputation-free survival in patients with critical limb ischemia. J Am Coll Cardiol 2014;63:682-90. https://doi.org/10.1016/j.jacc.2013.09.073
  18. Harris SK, Roos MG, Landry GJ. Statin use in patients with peripheral arterial disease. J Vasc Surg 2016;64:1881-8. https://doi.org/10.1016/j.jvs.2016.08.094
  19. Heart Protection Study Collaborative Group. Randomized trial of the effects of cholesterol-lowering with simvastatin on peripheral vascular and other major vascular outcomes in 20,536 people with peripheral arterial disease and other high-risk conditions. J Vasc Surg 2007;45:645-54; discussion 653-4. https://doi.org/10.1016/j.jvs.2006.12.054
  20. Antoniou GA, Fisher RK, Georgiadis GS, Antoniou SA, Torella F. Statin therapy in lower limb peripheral arterial disease: systematic review and meta-analysis. Vascul Pharmacol 2014;63:79-87. https://doi.org/10.1016/j.vph.2014.09.001

Cited by

  1. Clinical Outcomes of Subintimal vs. Intraluminal Revascularization Approaches for Long Femoropopliteal Occlusions in a Korean Multicenter Retrospective Registry Cohort vol.82, pp.7, 2017, https://doi.org/10.1253/circj.cj-17-1464
  2. Using the epidemiology of critical limb ischemia to estimate the number of patients amenable to endovascular therapy vol.25, pp.1, 2020, https://doi.org/10.1177/1358863x19878271
  3. Influence of preprocedural glycemic control on clinical outcomes of endovascular therapy in diabetic patients with lower extremity artery disease: an analysis from a Korean multicenter retrospective r vol.19, pp.None, 2017, https://doi.org/10.1186/s12933-020-01072-x
  4. Association between Body Mass Index and Clinical Outcomes of Peripheral Artery Disease after Endovascular Therapy: Data from K-VIS ELLA Registry vol.51, pp.8, 2017, https://doi.org/10.4070/kcj.2021.0040
  5. Drug Eluting Stent vs. Drug Coated Balloon for Native Femoropopliteal Artery Disease: A Two Centre Experience vol.61, pp.2, 2017, https://doi.org/10.1016/j.ejvs.2020.10.008
  6. Korean Multicenter Registry Study of EPIC Stents for the Treatment of Iliac Artery Disease: K-EPIC Registry vol.51, pp.5, 2017, https://doi.org/10.4070/kcj.2020.0420
  7. Clinical Outcomes of Atherectomy Plus Drug-coated Balloon Versus Drug-coated Balloon Alone in the Treatment of Femoropopliteal Artery Disease vol.52, pp.None, 2017, https://doi.org/10.4070/kcj.2021.0246