Natural Product Sciences

  • 제23권3호
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  • Pages.213-216
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  • 2017
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
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A new 3, 4-epoxyfurocoumarin from Heracleum moellendorffii Roots

  • Park, Sang Yeol (College of Pharmacy, Kangwon National University) ;
  • Lee, Nara (College of Pharmacy, Kangwon National University) ;
  • Lee, SunKyoung (College of Pharmacy, Kangwon National University) ;
  • Kim, Myong Jo (College of Agriculture and Life science, Kangwon National University) ;
  • Chun, Wanjoo (School of Medicine, Kangwon National University) ;
  • Kim, Hyun Pyo (College of Pharmacy, Kangwon National University) ;
  • Yang, Hee Jung (College of Pharmacy, Kangwon National University) ;
  • Lee, Ho Sun (Yanggu Agricultural Technology Center) ;
  • Kwon, Yongsoo (College of Pharmacy, Kangwon National University)
  • 투고 : 2017.04.11
  • 심사 : 2017.06.13
  • 발행 : 2017.09.29
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초록

Activity-guided isolation of Heracleum moellendorffii roots led to four coumarin derivatives as acetylcholinesterase inhibitors. The structures of these isolates were characterized by spectroscopic method to be angelicin (1), isobergapten (2), pimpinellin (3), and (3S, 4R)-3, 4-epoxypimpinellin (4). All the isolated compounds 1, 2, 3, and 4 showed moderate inhibition activities against acetylcholinesterase with the $IC_{50}$ values of 10.2, 18.1, 21.5 and $22.9{\mu}M$, respectively. (3S, 4R)-3, 4-Epoxypimpinellin (4) was newly isolated from the plant source.

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참고문헌

  1. Lee, W. T. Standard illustrations of Korean plants; Academy Pub. Co.: Seoul, 1996, p 254.
  2. Zhong, H. B. C. Editorial Committee of Zhong Hua Ben Cao of State Administration of Traditional Chinese Medicine of People's Republic of China Vol. 5; Shanghai Science and Technology Press; Shanghai, 1999, pp 960-962.
  3. Kwon, Y. S.; Cho, H. Y.; Kim, C. M. Yakhak Hoeji 2000, 44, 521-527.
  4. Bae, D. S.; Kim C. Y.; Lee, J. K. Int. Immunopharmacol. 2012, 14, 734-739. https://doi.org/10.1016/j.intimp.2012.10.009
  5. Park, H. J.; Nugroho, A.; Jung, B.; Won, Y. H.; Jung, Y. J.; Kim, W. B.; Choi, J. S. Koran J. Plant Res. 2010, 23, 393-398.
  6. Nakano, Y.; Matsuaga, H.; Saita, T.; Mori, M.: Katano, M.; Okabe, H. Biol. Pharm. Bull. 1998, 21, 257-261. https://doi.org/10.1248/bpb.21.257
  7. Li, W.; Chen, L.; Wu, C.; Xin, J. Asian J. Chem. 2013, 25, 4701-4702.
  8. Orhan, I. E.; Tosun, F.; Skalicka-Wozniak, K. S. J. Serb. Chem. Soc. 2016, 81, 357-368. https://doi.org/10.2298/JSC150902017O
  9. Dincel, D.; Hatipoglu, S. D.; Goren, A. C.; Topcu, G. Turk. J. Chem. 2013, 37, 675-683.
  10. Orhan, I.; Tosun, F.; Sener, B. Z. Naturforsch. C 2008, 63, 366-370.
  11. Ellman, G. L.; Courtney, K. D.; Andres Jr., V.; Feather-stone, R. M. Biochem. Pharmacol. 1961, 7, 88-95. https://doi.org/10.1016/0006-2952(61)90145-9
  12. Liu, S.; Zhang, W.; He, G.; Lei, P.; Li, X.; Liang, Y. Zhongguo Zhongyao Zazhi 2009, 34, 571-573.
  13. Steck, W.; Mazurek, M. Lloydia 1972, 35, 418-439.
  14. Luz, R. F.; Vieira, I. J. C.; Braz-Filho, R.; Moreira, V. F. Am. J. Analyt. Chem. 2015, 6, 851-866. https://doi.org/10.4236/ajac.2015.611081
  15. De Angelis, G. G.; Wildman, W. C. Tetrahedron 1969, 25, 5099-5112. https://doi.org/10.1016/S0040-4020(01)83255-5
  16. Dhooghe, L.; Maregesi, S.; Mincheva, I.; Ferreira, D.; Marais, J. P.; Lemiere, F.; Matheeussen, A.; Cos, P.; Maes, L.; Vlietinck, A.; Aperes S.; Pieters, L. Phytochemistry 2010, 71, 785-791. https://doi.org/10.1016/j.phytochem.2010.02.005

피인용 문헌

  1. Angelicin—A Furocoumarin Compound With Vast Biological Potential vol.11, pp.None, 2017, https://doi.org/10.3389/fphar.2020.00366