References
- Ahn KS, Kim YJ, Kim M, Lee BH, Heo SY, Kang MJ, Kang YK, Lee JW, Lee KK, Kim JH, Nho WG, Hwang SS, Woo JS, Park JK, Park SB and Shim H. 2011. Resurrection of an alpha-1,3-galactosyltransferase gene-targeted miniature pig by recloning using postmortem ear skin fibroblasts. Theriogenology 75:933-999. https://doi.org/10.1016/j.theriogenology.2010.11.001
- Azimzadeh AM, Kelishadi SS, Ezzelarab MB, Singh AK, Stoddard T, Iwase H, Zhang T, Burdorf L, Sievert E, Avon C, Cheng X, Ayares D, Horvath KA, Corcoran PC, Mohiuddin MM, Barth RN, Cooper DK, Pierson RN, 3rd. 2015. Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein. Xenotransplantation 22:310-316. https://doi.org/10.1111/xen.12176
- Beigi F, Patel M, Morales-Garza MA, Winebrenner C, Gobin AS, Chau E, Sampaio LC, and Taylor DA. 2017. Optimized method for isolating highly purified and functional porcine aortic endothelial and smooth muscle cells. J. Cell Physiol. 232:3139-3145 https://doi.org/10.1002/jcp.25764
- Chan BP, and Leong KW. 2008. Scaffolding in tissue engineering: general approaches and tissue-specific considerations. Eur Spine J. 17 Suppl 4:467-479. https://doi.org/10.1007/s00586-008-0745-3
- Chen P, Gao H, Lu Y, Nie H, Liu Z, Zhao Y, Fan N, Zou Q, Dai Y, Tang A, Hara H, Cai Z, Cooper DKC, Lai L, and Mou L. 2017. Altered expression of eNOS, prostacyclin synthase, prostaglandin G/H synthase, and thromboxane synthase in porcine aortic endothelial cells after exposure to human serum-relevance to xenotransplantation. Cell Biol. Int. 41:798-808. https://doi.org/10.1002/cbin.10782
- Cooper DK, Dorling A, Pierson RN, 3rd, Rees M, Seebach J, Yazer M, Ohdan H, Awwad M, and Ayares D. 2007. Alpha1, 3-galactosyltransferase gene-knockout pigs for xenotransplantation: where do we go from here? Transplantation 84:1-7. https://doi.org/10.1097/01.tp.0000260427.75804.f2
- Cowan PJ, and d'Apice AJ. 2009. Complement activation and coagulation in xenotransplantation. Immunol. Cell Biol. 87:203-208. https://doi.org/10.1038/icb.2008.107
- DeCicco-Skinner KL, Henry GH, Cataisson C, Tabib T, Gwilliam JC, Watson NJ, Bullwinkle EM, Falkenburg L, O'Neill RC, Morin A, and Wiest JS. 2014. Endothelial cell tube formation assay for the in vitro study of angiogenesis. J. Vis. Exp. 91:e51312.
- Iwase H, Ezzelarab MB, Ekser B, and Cooper DK. 2014. The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options. Xenotransplantation 21:201-220. https://doi.org/10.1111/xen.12085
- Kankanala J, Latham AM, Johnson AP, Homer-Vanniasinkam S, Fishwick CW, and Ponnambalam S. 2012. A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis. Br. J. Pharmacol. 166:737-748. https://doi.org/10.1111/j.1476-5381.2011.01801.x
- Kuwaki K, Tseng YL, Dor FJ, Shimizu A, Houser SL, Sanderson TM, Lancos CJ, Prabharasuth DD, Cheng J, Moran K, Hisashi Y, Mueller N, Yamada K, Greenstein JL, Hawley RJ, Patience C, Awwad M, Fishman JA, Robson SC, Schuurman HJ, Sachs DH, and Cooper DK. 2005. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat. Med. 11:29-31. https://doi.org/10.1038/nm1171
- Mahajan KD, Nabar GM, Xue W, Anghelina M, Moldovan N, Chalmers J, and Winter J. 2017. Mechanotransduction Effects on Endothelial Cell Proliferation via CD31 and VEGFR2: Implications for Immunomagnetic Separation. Biotechnol. J. doi:10.1002/biot.201600750.
- Mannucci PM. 1995. Platelet von Willebrand factor in inherited and acquired bleeding disorders. Proc. Natl. Acad. Sci. U S A. 92:2428-2432. https://doi.org/10.1073/pnas.92.7.2428
- Mohiuddin MM, Corcoran PC, Singh AK, Azimzadeh A, Hoyt RF, Jr, Thomas ML, Eckhaus MA, Seavey C, Ayares D, Pierson RN, 3rd, Horvath KA. 2012. B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months. Am. J. Transplant. 12:763-771. https://doi.org/10.1111/j.1600-6143.2011.03846.x
- Mohiuddin MM, Singh AK, Corcoran PC, Thomas Iii ML, Clark T, Lewis BG, Hoyt RF, Eckhaus M, Pierson Iii RN, Belli AJ, Wolf E, Klymiuk N, Phelps C, Reimann KA, Ayares D, and Horvath KA. 2016. Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO. hCD46. hTBM pig-to-primate cardiac xenograft. Nat. Commun. 7:11138. https://doi.org/10.1038/ncomms11138
- Muller AM1, Hermanns MI, Skrzynski C, Nesslinger M, Muller KM, and Kirkpatrick CJ. 2002. Expression of the endothelial markers PECAM-1, vWf, and CD34 in vivo and in vitro. Exp. Mol. Pathol. 72:221-229. https://doi.org/10.1006/exmp.2002.2424
- Novosel EC, Kleinhans C, and Kluger PJ. 2011. Vascularization is the key challenge in tissue engineering. Adv. Drug Deliv. Rev. 63:300-311. https://doi.org/10.1016/j.addr.2011.03.004
- Olmer R, and Martin U. 2014.Induced pluripotent stem cells differentiate into functional cardiomyocytes. In: and Hayat MA, ed. Stem cell and Cancer stem cells. vol 12. Netherlands: Springer: 47-62.
-
Ramm R, Hartmann T, Tudorache I, Haverich A, and Hilfiker A. 2015. No evidence for
${\alpha}Gal epitope transfer from media containing FCS onto human endothelial cells in culture. Xenotransplantation 22:345-355. https://doi.org/10.1111/xen.12183 - Sun QH, Paddock C, Visentin GP, Zukowski MM, Muller WA, and Newman PJ. 1998. Cell surface glycosaminoglycans do not serve as ligands for PECAM-1. PECAM-1 is not a heparin- binding protein. J. Biol. Chem. 273:11483-11490. https://doi.org/10.1074/jbc.273.19.11483
- Yamada K, Yazawa K, Shimizu A, Iwanaga T, Hisashi Y, Nuhn M, O'Malley P, Nobori S, Vagefi PA, Patience C, Fishman J, Cooper DK, Hawley RJ, Greenstein J, Schuurman HJ, Awwad M, Sykes M, and Sachs DH. 2005. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase geneknockout donors and the cotransplantation of vascularized thymic tissue. Nat. Med. 11:32-34. https://doi.org/10.1038/nm1172