The Korean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지)

Korean Academy of Oral and Maxillofacial Pathology (대한구강악안면병리학회)
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Increased Expression of CTGF in Periodontitis Tissue and Its Role for Enhanced Mature Osteoclast Survival

치주염 조직에서 발현이 증가하는 CTGF에 의한 파골세포 생존 증가

  • Han, Hye-Yeon (Department of Oral Pathology, School of Dentistry, Pusan National University) ;
  • Park, Jong-Cheol (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Ryu, Mi Heon (Department of Oral Pathology, School of Dentistry, Pusan National University) ;
  • Bae, Moon-Kyoung (BK21 PLUS Project, School of Dentistry, Pusan National University) ;
  • Kim, Hyung Joon (BK21 PLUS Project, School of Dentistry, Pusan National University)
  • 한혜연 (부산대학교 치의학전문대학원 구강병리학교실) ;
  • 박종철 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 유미현 (부산대학교 치의학전문대학원 구강병리학교실) ;
  • 배문경 (부산대학교 치의학전문대학원 BK21플러스 사업단) ;
  • 김형준 (부산대학교 치의학전문대학원 BK21플러스 사업단)
  • Received : 2017.07.10
  • Accepted : 2017.08.11
  • Published : 2017.08.31
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Abstract

Connective tissue growth factor (CTGF, CCN2) is one of the multi-functional secreted proteins which belong to CCN family of cysteine-rich growth factors. CTGF is known to have pivotal roles in embryonic endochondral ossification but its role in relevance to periodontitis is never been determined. To identify new molecular mediators associated with periodontitis-induced bone resorption, we have analyzed publicly available GEO database and found the markedly augmented CTGF mRNA expression in periodontitis gingival tissues. The existence of CTGF significantly enhanced mature osteoclasts survival which accompanied by reduction in TUNEL-positive nuclei and PARP cleavage. These results may provide another line of evidence the CTGF mediated prolonged osteoclast survival and subsequent increased bone resorption in the periodontitis patients.

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Acknowledgement

Supported by : 한국연구재단