Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
권호 표지
DOI QR코드

DOI QR Code

A Study of the Anti-Stress Effects of Chijasitang in Mice

생쥐에서 치자시탕(梔子豉湯)의 항스트레스 효과에 대한 연구

  • Jung, Se-In (Department of Neuropsychiatry, College of Korean Medicine, Wonkwang University) ;
  • Kim, Jae-Hyo (Department of Meridian & Acupoint, College of Korean Medicine, Wonkwang University) ;
  • Lee, Go-Eun (Department of Oriental Rehabilitative Medicine, Korean National Rehabilitation Center) ;
  • Lyu, Yeoung-Su (Department of Neuropsychiatry, College of Korean Medicine, Wonkwang University) ;
  • Kang, Hyung Won (Department of Neuropsychiatry, College of Korean Medicine, Wonkwang University)
  • 정세인 (원광대학교 한의과대학 한방신경정신과교실) ;
  • 김재효 (원광대학교 경혈학교실) ;
  • 이고은 (국립재활원 한방재활의학과) ;
  • 유영수 (원광대학교 한의과대학 한방신경정신과교실) ;
  • 강형원 (원광대학교 한의과대학 한방신경정신과교실)
  • Received : 2017.08.25
  • Accepted : 2017.09.15
  • Published : 2017.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: Chijasitang (CJST) has been prescribed for patients with anxiety disorder, and is believed to treat insomnia. The present study was carried out to investigate whether Fructus Gardeniae, Fermented Semen Sojae Preparatum and CJST have beneficial effects on treating anti-stress. Methods: The mice were divided into the following groups: normal, control, positive control, and experimental. Then, the experimental groups were further divided into the Fructus Gardeniae group (FG), the Fermented Semen Sojae Preparatum group (FS), the Chijasitang water extract group (CJSTW), and the Chijasitang 30% ethanol extract group (CJSTE). In the positive control group, a single dose of imipramine ($500{\mu}g/g$) was applied to the mice. In the experimental groups, each single dose of FG, FS, CJSTW and CJSTE ($50{\mu}g/g$) was applied to the mice. After one hour, the mice in all groups except the normal group were exposed to immobilization stress. Their body weights, phagocytosis, nitric oxide in macrophage, corticosterone, and adrenocorticotropic hormone (ACTH) were observed. Results: Fructus Gardeniae, Fermented Semen Sojae Preparatum and Chijasitang prevented weight loss and suppressed the decrease of phagocytosis in the mice after their exposure to immobilization-stress. Although they did not influence the amount of NO, they suppressed the increment of ACTH and corticosterone in the immobilization-stressed mice. Conclusions: According to the results of this study, they suggest that Fructus Gardeniae, Fermented Semen Sojae Preparatum and Chi-Ja-Si-Tang all have some anti-stress effects.

Keywords

References

  1. David G. Myers. Psychology of Myers. Seoul:Sigmapress. 2012:354.
  2. Füchsl AM, Reber SO. Chronic Psychosocial Stress and Negative Feedback Inhibition. PLoS ONE. 2016;11(4):153-64.
  3. Min SK. The Newest Psychiatry. 5nd rev. ed. Seoul: Ilchokak. 2011:63, 65.
  4. Knuth BS, Cocco RA, Radtke VA, Medeiros JR, Oses JP, Wiener CD, Jansen K. Stress, depression, quality of life and salivary cortisol levels in community health agents. Acta Neuropsychiatrica. 2016;28(3):165-72. https://doi.org/10.1017/neu.2015.58
  5. Sung HH, Song CS, Choi KM, Park CE. A Study on the Relationship between Obesity Factors and NK Cell Activity in White-Collar Females. Korean J Clin Lab Sci. 2016;48(3):196-201. https://doi.org/10.15324/kjcls.2016.48.3.196
  6. Lee KW. Pyeonjuseokhae Hwangjenaegyeong-Youngchu. Seoul:Yeokang. 2000:(1)317, (2)197.
  7. Chen L. Chewuze-Saminbang. Taipei:Daeyeonkugpoong. 1978;(2):6.
  8. The Uiversity of Korean Medicine Neuropsychiatry textbook Compilation Committee. Korean medical psychotherapy. 3nd rev. ed. Paju:Jipmoondang. 2016:191-9, 476.
  9. Zhang JB. Kyungakjeonsuh. Seoul:Jeongdam. 1999: (Sang)381-386, 1266, (Ha):23, 147.
  10. Cho MJ, Chang SM, Hahm BJ, Chung IW, Bae A, Lee YM, Ahn JH, Won SH, Son JW, Hong JP, Bae JN, Lee DW, Cho SJ, Park JI, Lee JY, Kim JY, Jeon HJ, Lee HW. Prevalence and Correlates of Major Mental Disorders among Korean Adults. Journal of The Korean Neuropsychiatric Association. 2009;48(3):143-52.
  11. Lee KK. Adverse Effect of Newer Antidepressant. Korean Journal of Psychosomatic Medicine. 2013;21(2):81-92.
  12. Chae IS. Sanghanlonyeokjeon. Seoul:Komoonsa. 2000:70-2, 171.
  13. Heo Jun. Donguibogam. Seoul:Donguibogam. 2005:1091, 1735.
  14. Yuan SL : The therapy centered Application of Chi-Ja-Si-Tang(zhi-zi-chi-tang) on Mind-Body disease. Yunnan Zhongyi Zhongyao Zazhi. 2013;34(6):76-7.
  15. Park CH, Lee TH. Effects of Gardeniae Fructus on Corticotropin-Releasing Factor, c-fos and Tyrosine Hydroxylase in Forced Swimming Test. The Korean Journal of Oriental Medical Prescription. 2009;17(1):163-73.
  16. Oh JJ, Lee TH. Effects of Mixture of Lycii Radicis Cortex and Gardeniae Fructus on the Change of HPA-Axis and Catecholamine System in the Forced Swimming Test. Herbal formula science. 2012;20(1):51-65. https://doi.org/10.14374/HFS.2012.20.1.051
  17. Cho EJ, Park HY, Kim HY. Increased antioxidative effects of Seolitae Chungkukjang added with green tea powders. Journal of agricultural science. 2012;39(1):75-9.
  18. Kong HJ, Park HS, Shin SR, Hong JY, Yang KM. Analysis of Nutrition and Antioxidants of Yak-Kong Chungkukjang Powder Added Black Foods. Journal of the Korean Society of Food Science and Nutrition. 2013;42(11):1727-35. https://doi.org/10.3746/jkfn.2013.42.11.1727
  19. Lee SI, Cho MS, Lee SJ, Jeong JK. A Case Study of Chronic Anal Fissure Treated With Chijasi-tang and Counseling. Herbal formula science. 2015;23(1):161-9. https://doi.org/10.14374/HFS.2015.23.1.161
  20. Tazuno KO. Hanbangibmun. Seoul:Gyechuk. 1999:(Sang)125.
  21. Oochuka TM. Reality of Chinese traditional treatment. Seoul:Haenglim. 1985:429.
  22. Shin MK. Clinical herbalogical book. Seoul:Yeonglimsa. 2000:373.
  23. Kim HC. Herbal medicine pharmacology. 1nd rev. ed. Seoul. Jipmoondang. 2001:125-7.
  24. Kim GW, Chung MH. Protective Effects of geniposide and Extract of Korean Gardeniae Fructus. The Korean Society of Pharmacognosy. 1994;25(4):368-81.
  25. Koo HJ, Park EH. Pharmacological Activities of Extract and Constituents from Gardenia jasminoides. Journal of pharmaceutical sciences, Sookmyung Women's University. 2004;21:1-8.
  26. Cho JU, Choi SY, Kim KA, Keum KS, Lyu IS, Kim JU, Hwang WJ. Effects of water extract of gardenia on renal natriuretic peptide system. The Journal of Traditional Korean Medicine. 2004;14(1):101-18.
  27. Sanghae Science Technology Publisher. Unabridged Dictionary of Chinese medicine. Seoul:Jeongdam. 1997:(2):871.
  28. Han SY, Kim DH, Kim SH. Sanghanlon-The Study on Chijasitang Group. Journal of the Institute Oriental Medicine. 1999;7(2):385-97.
  29. Jegal KH, Kim YW, Byun SH. Analysis of herbal formulation about a series of Chijasi-tang in Dongeuibogam. Herbal formula science. 2012;20(2):177-86. https://doi.org/10.14374/HFS.2012.20.2.177
  30. Lee KW. Pyeonjuseokhae Hwangjenaegyeong-Somun. Seoul:Yeokang. 1999;(5):370.
  31. Lee HG, Kim HY, Park HJ, Seo JH, Lyu YS, Kang HW.The effect of Da-Huang, Huang-Lian and Dahuanghuanglianxiexin-tang(DHXT) on ability to recover from the stressful conditions in immobilization stressed ICR-mice. The Korean Society of Oriental Neuropsychiatry. 2011;22(1):53-67. https://doi.org/10.7231/JON.2011.22.1.053
  32. Lyu YS, Park JM, Ko IS, Kang HW, Lyu YS. The Anxiolytic, Anti-Depressive Effects Using Bambusae Caulis in Taeniam Extract in Rat Chronic Immobilization Stress Model. The Korean Society of Oriental Neuropsychiatry. 2013;24(3):293-308. https://doi.org/10.7231/jon.2013.24.3.293
  33. Korean Neuropsychiatric Association. Neuropsychiatry. 5nd rev. ed. Seoul:joongang. 2005:138, 173, 291, 293, 522.
  34. Sadler P, McLaren S, Klein B, Jenkins M and Harvey J. Cognitive behaviour therapy for older adults experiencing insomnia and depression in a community mental health setting. Trials. 2015;16:538-49. https://doi.org/10.1186/s13063-015-1066-6
  35. Taylor DJ, Lichstein KL, Durrence HH, Reidel BW, Bush AJ. Epidemiology of insomnia, depression and anxiety. Sleep. 2005;28(11):1457-64. https://doi.org/10.1093/sleep/28.11.1457
  36. Mark HB, Robert B. The Merck manual. 17nd rev. ed. Seoul:Hanuri. 2003:1643.
  37. Reyes TM, Walker JR, DeCino C, Hogenesch JB, Sawchenko PE. Categorically distinct acute stressors elicit dissimilar transcriptional profiles in the paraventricular nucleus of the hypothalamus. J Neurosci. 2003;23(13):5607-16. https://doi.org/10.1523/JNEUROSCI.23-13-05607.2003
  38. Marti O, Gavalda A, Jolin T, Armario A. Effect of regularity of exposure to chronic immobilization stress on the circadian pattern of pituitary adrenal horemones, growth horemone and thyroid stimulating horemone in the adult male rat. Psychoneuroendocrinology. 1993;18(1):67-77. https://doi.org/10.1016/0306-4530(93)90056-Q
  39. Giordano R, Pellegrino M, Picu A. Neuroregulation of the hypothalamus-pituitary-adrenal (HPA) axis in humans. Scientific World J. 2006;6:1-11.
  40. Stanford MR. Central noradrenergic neurones and stress. Pharmacol Ther. 1995;68:297-342. https://doi.org/10.1016/0163-7258(95)02010-1
  41. Plaut M. Lymphocyte hormone receptors. Ann Rev Immunol. 1987;5:621-69. https://doi.org/10.1146/annurev.iy.05.040187.003201
  42. Unane ER. Antigen presenting function of the macrophage. Ann Rev Immunol. 1984;2:395. https://doi.org/10.1146/annurev.iy.02.040184.002143
  43. Cohn ZA. The activation of mononuclear phagocytes. J Immunol. 1978;121:813-6.
  44. El MA, Matsuyama H, Borgan MA. Thymoquinone suppress expression of inducible nitric oxide synthase in rat macrophages. International Immunopharmacology. 2002;2:1603-11. https://doi.org/10.1016/S1567-5769(02)00139-X
  45. Arango C, Breier A, McMahon R, Carpenter WT Jr, Buchanan RW. The relationship of clozapine and haloperidol treatment response to prefrontal, hippocampal, and caudate brain volumes. Am J Psychiatry. 2003;160:1421-7. https://doi.org/10.1176/appi.ajp.160.8.1421
  46. Jacobs BL, Praag H, Gage FH. Adult brain neurogenesis and psychiatry. Mol Psychiatry. 2000;5:262-9. https://doi.org/10.1038/sj.mp.4000712

Cited by

  1. A System-Level Mechanism of Anmyungambi Decoction for Obesity: A Network Pharmacological Approach vol.11, pp.12, 2021, https://doi.org/10.3390/biom11121881