Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Anti-Oxidant and Hair-Growth-Promoting Effect of Pectin Lyase-Modified Red Ginseng Extract (GS-E3D)

홍삼가수분해추출물(GS-E3D)의 항산화 및 양모 효과

  • 표미경 ((재)금산국제인삼약초연구소) ;
  • 홍세철 ((재)금산국제인삼약초연구소) ;
  • 정종태 ((재)금산국제인삼약초연구소) ;
  • 조윤호 ((재)금산국제인삼약초연구소) ;
  • 이기무 ((주)세화피앤씨)
  • Received : 2017.07.31
  • Accepted : 2017.09.01
  • Published : 2017.09.30
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Abstract

To develop new therapy for prevention and treatment of hair loss is very important according to increase of the number of hair loss people. The aim of this study was to investigate the hair growth promoting effects of pectin lyase-modified red ginseng extract (GS-E3D). We examined antioxidant and anti-inflammatory effects, human hair dermal papilla cells (HHDPC) proliferation, and testoterone-induced $5{\alpha}$-reductase inhibitory effects. GS-E3D show not only 1,1-diphenyl-2-picryhydrazyl (DPPH) radical scavenging activity and xanthine oxidase inhibitory effects as an anti-oxidant property, but also lip-oxygenase and hyaluronidase inhibitory effects as an anti-inflammatory property. Human hair dermal papilla cells proliferation by GS-E3D was higher than those of minoxidil or finasteride, using the positive controls. Moreover, GS-E3D exhibited $5{\alpha}$-reductase inhibitory activities after stimulating by testoterone. The present results indicate that GS-E3D has a potential to be as an hair growth promoting agent for cosmetic materials.

Keywords

References

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